{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,15]],"date-time":"2026-11-15T02:58:58Z","timestamp":1794711538365,"version":"4.9.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"28","license":[{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003100","name":"F\u00e9d\u00e9ration Fran\u00e7aise de Cardiologie","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003100","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Assistance Publique des H\u00f4pitaux de Paris"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To investigate the incidence of major adverse ventricular arrhythmias and related events (MAREs) and to develop a stratification tool predicting MAREs in adults with a systemic right ventricle (sRV).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>In a multicentre approach, all adults (\u226516 years old) with a sRV undergoing follow-up between 2000 and 2018 were identified. The incidence of MAREs, defined as sudden cardiac death, sustained ventricular tachycardia, and appropriate implantable cardioverter-defibrillator (ICD) therapy, was analysed. The association of MAREs with clinical, electrical, and echocardiographic parameters was evaluated. A total of 1184 patients (median age 27.1 years; interquartile range 19.9\u201334.9 years; 59% male; 70% with atrial switch repair for D-transposition of the great arteries) were included. The incidence of MAREs was 6.3 per 1000 patient-years. On multivariate analysis, age, history of heart failure, syncope, QRS duration, severe sRV dysfunction and at least moderate left ventricular outflow tract obstruction were retained in the final model with a C-index of 0.78 [95% confidence interval (CI) 0.72\u20130.83] and a calibration slope of 0.93 (95% CI 0.64\u20131.21). For every five ICDs implanted in patients with a 5-year MARE risk &amp;gt;10%, one patient may potentially be spared from a MARE.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Sudden cardiac death remains a devastating cause of death in a contemporary adult cohort with a sRV. A prediction model based on clinical, electrocardiographic, and echocardiographic parameters was devised to estimate MARE risk and to identify high-risk patients who may benefit from primary prevention ICD implantation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehac288","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T07:51:09Z","timestamp":1654674669000},"page":"2685-2694","source":"Crossref","is-referenced-by-count":57,"title":["A new score for life-threatening ventricular arrhythmias and sudden cardiac death in adults with transposition of the great arteries and a systemic right ventricle"],"prefix":"10.1093","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4325-3521","authenticated-orcid":false,"given":"Magalie","family":"Ladouceur","sequence":"first","affiliation":[{"name":"Centre de r\u00e9f\u00e9rence des Malformations Cardiaques Cong\u00e9nitales Complexes, M3C, Adult Congenital Heart Disease Unit, H\u00f4pital Europ\u00e9en Georges Pompidou, APHP, Paris Cit\u00e9 University , Paris 75015 , France"},{"name":"Centre de Recherche Cardiovasculaire de Paris, INSERM U970 , 20 rue Leblanc, Paris 75015 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0469-8640","authenticated-orcid":false,"given":"Alexander","family":"Van De Bruaene","sequence":"additional","affiliation":[{"name":"Division of Congenital and Structural Cardiology, University Hospitals Leuven, and Catholic University Leuven , Leuven , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8654-7634","authenticated-orcid":false,"given":"Robert","family":"Kauling","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thoraxcenter, ErasmusMC, University Medical Center Rotterdam , Rotterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5850-5413","authenticated-orcid":false,"given":"Werner","family":"Budts","sequence":"additional","affiliation":[{"name":"Division of Congenital and Structural Cardiology, University Hospitals Leuven, and Catholic University Leuven , Leuven , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6770-3830","authenticated-orcid":false,"given":"Jolien","family":"Roos-Hesselink","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thoraxcenter, ErasmusMC, University Medical Center Rotterdam , Rotterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2122-0825","authenticated-orcid":false,"given":"Sandra Villagr\u00e1","family":"Albert","sequence":"additional","affiliation":[{"name":"Paediatric Cardiology and ACHD Unit, Ramon y Cajal University 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Hospital and University of Lausanne , Lausanne , Switzerland"},{"name":"Service de Cardiologie, D\u00e9partement de M\u00e9decine, H\u00f4pitaux Universitaires de Gen\u00e8ve , 1205 Gen\u00e8ve , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3448-2610","authenticated-orcid":false,"given":"Coralie","family":"Blanche","sequence":"additional","affiliation":[{"name":"Service de Cardiologie, D\u00e9partement de M\u00e9decine, H\u00f4pitaux Universitaires de Gen\u00e8ve , 1205 Gen\u00e8ve , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5899-291X","authenticated-orcid":false,"given":"Tobias","family":"Rutz","sequence":"additional","affiliation":[{"name":"Service of Cardiology, Lausanne University Hospital and University of Lausanne , Lausanne , 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