{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:36:27Z","timestamp":1788561387983,"version":"build-2803163510"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"38","license":[{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Diagnostic criteria for ambulatory blood pressure monitoring (ABPM) in patients with suspected reflex syncope are lacking. The study hypothesis was that patients with reflex syncope have a higher prevalence of systolic blood pressure (SBP) drops on ABPM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>ABPM data from reflex syncope patients and controls, matched by average 24\u2005h SBP, age, sex, and hypertension were compared. Patients with constitutional hypotension, orthostatic hypotension, and predominant cardioinhibition during carotid sinus massage or prolonged electrocardiogram monitoring or competing causes of syncope were excluded. Daytime and nighttime SBP drops (&amp;lt;110, 100, 90, 80\u2005mmHg) were assessed. Findings were validated in an independent sample. In the derivation sample, daytime SBP drops were significantly more common in 158 syncope patients than 329 controls. One or more daytime drops &amp;lt;90\u2005mmHg achieved 91% specificity and 32% sensitivity [odds ratio (OR) 4.6, P\u2009&amp;lt;\u20090.001]. Two or more daytime drops &amp;lt;100\u2005mmHg achieved 84% specificity and 40% sensitivity (OR 3.5, P\u2009=\u20090.001). Results were confirmed in the validation sample of 164 syncope patients and 164 controls: one or more daytime SBP drops &amp;lt;90\u2005mmHg achieved 94% specificity and 29% sensitivity (OR 6.2, P\u2009&amp;lt;\u20090.001), while two or more daytime SBP drops &amp;lt;100\u2005mmHg achieved 83% specificity and 35% sensitivity (OR 2.6, P\u2009&amp;lt;\u20090.001)<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SBP drops during ABPM are more common in reflex syncope patients than in controls. Cut-off values that may be applied in clinical practice are defined. This study expands the current indications for ABPM to patients with reflex syncope.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehac347","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T05:52:54Z","timestamp":1656481974000},"page":"3765-3776","source":"Crossref","is-referenced-by-count":57,"title":["Association between hypotension during 24\u2005h ambulatory blood pressure monitoring and reflex syncope: the SynABPM 1 study"],"prefix":"10.1093","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2736-2242","authenticated-orcid":false,"given":"Giulia","family":"Rivasi","sequence":"first","affiliation":[{"name":"Division of Geriatric and Intensive Care Medicine, University of Florence and Azienda Ospedaliero Universitaria Careggi , Largo Brambilla 3, 50139 Florence , 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