{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T23:43:49Z","timestamp":1770075829467,"version":"3.49.0"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"36","license":[{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100010447","name":"DZHK","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010447","name":"German Centre for Cardiovascular Research","doi-asserted-by":"crossref","award":["81X2710153"],"award-info":[{"award-number":["81X2710153"]}],"id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"crossref"}]},{"name":"German Ministry of Education and Research"},{"name":"BMBF"},{"name":"European Union Horizon 2020"},{"name":"REANIMA","award":["874764"],"award-info":[{"award-number":["874764"]}]},{"name":"TrainHeart","award":["813716"],"award-info":[{"award-number":["813716"]}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"crossref"}]},{"name":"BHF-DZHK","award":["81X2710176"],"award-info":[{"award-number":["81X2710176"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,21]]},"DOI":"10.1093\/eurheartj\/ehac397","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T05:13:56Z","timestamp":1659590036000},"page":"3490-3492","source":"Crossref","is-referenced-by-count":2,"title":["Activation of an accessory pathway of glucose metabolism to treat dilated cardiomyopathy"],"prefix":"10.1093","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1750-1170","authenticated-orcid":false,"given":"Thomas","family":"Eschenhagen","sequence":"first","affiliation":[{"name":"Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg Eppendorf , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,8,4]]},"reference":[{"key":"2022092120394688900_ehac397-B1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nrcardio.2013.105","article-title":"Dilated cardiomyopathy: the complexity of a diverse genetic architecture","volume":"10","author":"Hershberger","year":"2013","journal-title":"Nat Rev Cardiol"},{"key":"2022092120394688900_ehac397-B2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1161\/CIRCULATIONAHA.120.053033","article-title":"Evidence-based assessment of genes in dilated cardiomyopathy","volume":"144","author":"Jordan","year":"2021","journal-title":"Circulation"},{"key":"2022092120394688900_ehac397-B3","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1016\/S0140-6736(99)04440-2","article-title":"Effect of metoprolol CR\/XL in chronic heart failure: Metoprolol Cr\/Xl Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF)","volume":"353","year":"1999","journal-title":"Lancet"},{"key":"2022092120394688900_ehac397-B4","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJM199909023411001","article-title":"The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized aldactone evaluation study investigators","volume":"341","author":"Pitt","year":"1999","journal-title":"N Engl J Med"},{"key":"2022092120394688900_ehac397-B5","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1056\/NEJMoa1409077","article-title":"Angiotensin\u2013neprilysin inhibition versus enalapril in heart failure","volume":"371","author":"McMurray","year":"2014","journal-title":"N Engl J Med"},{"key":"2022092120394688900_ehac397-B6","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1056\/NEJMoa1911303","article-title":"Dapagliflozin in patients with heart failure and reduced ejection fraction","volume":"381","author":"McMurray","year":"2019","journal-title":"N Engl J Med"},{"key":"2022092120394688900_ehac397-B7","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur Heart J"},{"key":"2022092120394688900_ehac397-B8","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1161\/CIRCULATIONAHA.119.037661","article-title":"Reevaluating the genetic contribution of monogenic dilated cardiomyopathy","volume":"141","author":"Mazzarotto","year":"2020","journal-title":"Circulation"},{"key":"2022092120394688900_ehac397-B9","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1056\/NEJMoa1706198","article-title":"Single-dose gene-replacement therapy for spinal muscular atrophy","volume":"377","author":"Mendell","year":"2017","journal-title":"N Engl J Med"},{"key":"2022092120394688900_ehac397-B10","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1126\/science.aau1549","article-title":"Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy","volume":"362","author":"Amoasii","year":"2018","journal-title":"Science"},{"key":"2022092120394688900_ehac397-B11","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1093\/eurheartj\/ehac305","volume":"43","year":"2022","journal-title":"Eur Heart J"},{"key":"2022092120394688900_ehac397-B12","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.jacc.2017.11.067","article-title":"Activation of serine one-carbon metabolism by calcineurin abeta1 reduces myocardial hypertrophy and improves ventricular function","volume":"71","author":"Padron-Barthe","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2022092120394688900_ehac397-B13","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1161\/CIRCULATIONAHA.119.044452","article-title":"The role of nonglycolytic glucose metabolism in myocardial recovery upon mechanical unloading and circulatory support in chronic heart failure","volume":"142","author":"Badolia","year":"2020","journal-title":"Circulation"},{"key":"2022092120394688900_ehac397-B14","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/nbt1358","article-title":"A quantitative analysis of kinase inhibitor selectivity","volume":"26","author":"Karaman","year":"2008","journal-title":"Nat Biotechnol"}],"container-title":["European Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/43\/36\/3490\/45955633\/ehac397.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/43\/36\/3490\/45955633\/ehac397.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T16:01:13Z","timestamp":1676304073000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurheartj\/article\/43\/36\/3490\/6655452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,4]]},"references-count":14,"journal-issue":{"issue":"36","published-online":{"date-parts":[[2022,8,4]]},"published-print":{"date-parts":[[2022,9,21]]}},"URL":"https:\/\/doi.org\/10.1093\/eurheartj\/ehac397","relation":{},"ISSN":["0195-668X","1522-9645"],"issn-type":[{"value":"0195-668X","type":"print"},{"value":"1522-9645","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,9,21]]},"published":{"date-parts":[[2022,8,4]]}}}