{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:15:14Z","timestamp":1793330114686,"version":"4.5.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordic Foundation","doi-asserted-by":"publisher","award":["NNFSA170030576"],"award-info":[{"award-number":["NNFSA170030576"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The long-term survival of patients with isolated congenital ventricular septal defect (VSD) is not well described. The aim of this study was to describe the survival of a national cohort of patients with VSD compared with the general population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Using Danish nationwide medical registries, all patients diagnosed with congenital VSD (n = 9,136) in the period 1977\u20132018 were included. Patients with chromosomal abnormalities and concomitant congenital cardiac malformations other than atrial septal defect were excluded. Each patient was matched by birthyear and sex with ten controls from the general Danish population. Kaplan\u2212Meier survival function and Cox proportional hazard regression were used to compute survival and mortality risk. Median follow-up was 22 years (interquartile range: 11\u201337). VSD patients displayed lower survival (P&amp;lt;0.001) yielding a hazard ratio (HR) for mortality of 2.7 [95% confidence interval (CI): 2.4\u20133.0] compared with matched controls. The adjusted HR for mortality among patients with unrepaired VSD was 2.7 (95% CI: 2.4\u20133.0) and 2.8 (95% CI: 2.1\u20133.7) for patients with surgically closed VSD. Stratified by era of VSD diagnosis, the HR for mortality was 3.2 (95% CI: 2.8\u20133.7) for unrepaired patients diagnosed before 1990 and 2.4 (95% CI: 2.0\u20132.7) for patients diagnosed later. Cardiac-related death was the commonest cause of death among unrepaired (30%) and surgically closed (65%) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with VSD had lower survival compared with the general population. The HR for mortality was increased over 2.5-fold in patients with unrepaired defect (Eisenmenger syndrome excluded) and over 1.5-fold in patients with surgically closed defect (excluding surgical mortality).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehac618","type":"journal-article","created":{"date-parts":[[2022,10,16]],"date-time":"2022-10-16T08:46:03Z","timestamp":1665909963000},"page":"54-61","source":"Crossref","is-referenced-by-count":45,"title":["Survival of patients with congenital ventricular septal defect"],"prefix":"10.1093","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3295-2930","authenticated-orcid":false,"given":"Filip","family":"Eckerstr\u00f6m","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, Copenhagen University Hospital , Blegdamsvej 9, 2100 K\u00f8benhavn \u00d8 , Denmark"},{"name":"Department of Clinical Medicine, Copenhagen University Hospital , Blegdamsvej 9, 2100 K\u00f8benhavn \u00d8 , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8543-7257","authenticated-orcid":false,"given":"Camilla","family":"Nyboe","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital , Palle Juul-Jensen Boulevard, 8200 Aarhus N , Denmark"},{"name":"Department of Clinical Medicine, Aarhus University Hospital , Palle Juul-Jensen Boulevard, 8200 Aarhus N , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6705-3807","authenticated-orcid":false,"given":"Marie","family":"Maagaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aarhus University Hospital , Palle Juul-Jensen Boulevard, 8200 Aarhus N , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6616-6316","authenticated-orcid":false,"given":"Andrew","family":"Redington","sequence":"additional","affiliation":[{"name":"The Heart Institute, Cincinnati Children's Hospital Medical Center , 3333 Burnet Avenue, Cincinnati, Ohio , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8047-0015","authenticated-orcid":false,"given":"Vibeke Elisabeth","family":"Hjortdal","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Copenhagen University Hospital , Blegdamsvej 9, 2100 K\u00f8benhavn \u00d8 , Denmark"},{"name":"Department of Clinical Medicine, Copenhagen University Hospital , Blegdamsvej 9, 2100 K\u00f8benhavn \u00d8 , 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