{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:29:48Z","timestamp":1740126588607,"version":"3.37.3"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,21]]},"DOI":"10.1093\/eurheartj\/ehac685","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T08:02:21Z","timestamp":1669881741000},"page":"254-255","source":"Crossref","is-referenced-by-count":0,"title":["Protection and delay of aortic complications in the Marfan syndrome: a new indication for angiotensin receptor blockers on top of \u03b2 blockers"],"prefix":"10.1093","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4218-3066","authenticated-orcid":false,"given":"Daniela","family":"Pedicino","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Fondazione Policlinico Universitario A. Gemelli\u2014IRCCS , Largo A. Gemelli 8, Rome 00168 , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9642-8380","authenticated-orcid":false,"given":"Massimo","family":"Volpe","sequence":"additional","affiliation":[{"name":"Cardiology Department, Sapienza University of Rome, Sant'Andrea Hospital , Via di Grottarossa 1035-1039, 00189 Rome , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"key":"2023012107594045500_ehac685-B1","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S0140-6736(22)01534-3","article-title":"Angiotensin receptor blockers and \u03b2 blockers in marfan syndrome: an individual patient data meta-analysis of randomised trials","volume":"400","author":"Pitcher","year":"2022","journal-title":"Lancet"},{"author":"The Marfan Foundation","key":"2023012107594045500_ehac685-B2"},{"key":"2023012107594045500_ehac685-B3","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1093\/eurheartj\/ehu281","article-title":"2014 ESC guidelines on the diagnosis and treatment of aortic diseases: document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. The task force for the diagnosis and treatment of aortic diseases of the European society of cardiology (ESC)","volume":"35","author":"Erbel","year":"2014","journal-title":"Eur Heart J"},{"key":"2023012107594045500_ehac685-B4","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1126\/science.1124287","article-title":"Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of marfan syndrome","volume":"312","author":"Habashi","year":"2006","journal-title":"Science"},{"key":"2023012107594045500_ehac685-B5","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1056\/NEJMoa0706585","article-title":"Angiotensin II blockade and aortic-root dilation in marfan's syndrome","volume":"358","author":"Brooke","year":"2008","journal-title":"N Engl J Med"},{"key":"2023012107594045500_ehac685-B6","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1093\/eurheartj\/ehv151","article-title":"Marfan sartan: a randomized, double-blind, placebo-controlled trial","volume":"36","author":"Milleron","year":"2015","journal-title":"Eur Heart J"},{"key":"2023012107594045500_ehac685-B7","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1093\/eurheartj\/eht334","article-title":"Losartan reduces aortic dilatation rate in adults with marfan syndrome: a randomized controlled trial","volume":"34","author":"Groenink","year":"2013","journal-title":"Eur Heart J"},{"key":"2023012107594045500_ehac685-B8","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.ijcard.2010.12.070","article-title":"The Ghent marfan trial\u2013a randomized, double-blind placebo controlled trial with losartan in marfan patients treated with \u03b2-blockers","volume":"157","author":"M\u00f6berg","year":"2012","journal-title":"Int J Cardiol"},{"key":"2023012107594045500_ehac685-B9","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1093\/eurheartj\/ehv575","article-title":"Efficacy of losartan vs. Atenolol for the prevention of aortic dilation in marfan syndrome: a randomized clinical trial","volume":"37","author":"Forteza","year":"2016","journal-title":"Eur Heart J"},{"key":"2023012107594045500_ehac685-B10","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.amjcard.2020.04.034","article-title":"Meta-analysis examining the usefulness of angiotensin receptor blockers for the prevention of aortic root dilation in patients with the marfan syndrome","volume":"128","author":"Al-Abcha","year":"2020","journal-title":"Am J Cardiol"},{"key":"2023012107594045500_ehac685-B11","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1056\/NEJMoa1404731","article-title":"Atenolol versus losartan in children and young adults with marfan's syndrome","volume":"371","author":"Lacro","year":"2014","journal-title":"N Engl J Med"}],"container-title":["European Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/44\/4\/254\/48806963\/ehac685.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/44\/4\/254\/48806963\/ehac685.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T08:00:17Z","timestamp":1674288017000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurheartj\/article\/44\/4\/254\/6855565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,1]]},"references-count":11,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,12,1]]},"published-print":{"date-parts":[[2023,1,21]]}},"URL":"https:\/\/doi.org\/10.1093\/eurheartj\/ehac685","relation":{},"ISSN":["0195-668X","1522-9645"],"issn-type":[{"type":"print","value":"0195-668X"},{"type":"electronic","value":"1522-9645"}],"subject":[],"published-other":{"date-parts":[[2023,1,21]]},"published":{"date-parts":[[2022,12,1]]}}}