{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T18:12:14Z","timestamp":1794507134756,"version":"4.9.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Heart Failure"},{"name":"Society of Internal Medicine."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate whether the addition of hydrochlorothiazide (HCTZ) to intravenous furosemide is a safe and effective strategy for improving diuretic response in acute heart failure (AHF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>A prospective, double-blind, placebo-controlled trial, including patients with AHF randomized to receive HCTZ or placebo in addition to an intravenous furosemide regimen. The coprimary endpoints were changes in body weight and patient-reported dyspnoea 72\u2005h after randomization. Secondary outcomes included metrics of diuretic response and mortality\/rehospitalizations at 30 and 90 days. Safety outcomes (changes in renal function and\/or electrolytes) were also assessed. Two hundred and thirty patients (48% women, 83 years) were randomized. Patients assigned to HCTZ were more likely to lose weight at 72\u2005h than those assigned to placebo [\u22122.3 vs. \u22121.5\u2005kg; adjusted estimated difference (notionally 95% confidence interval) \u22121.14 (\u22121.84 to \u22120.42); P = 0.002], but there were no significant differences in patient-reported dyspnoea (area under the curve for visual analogue scale: 960 vs. 720; P = 0.497). These results were similar 96\u2005h after randomization. Patients allocated to HCTZ showed greater 24\u2005h diuresis (1775 vs. 1400\u2005mL; P = 0.05) and weight loss for each 40\u2005mg of furosemide (at 72 and at 96\u2005h) (P &amp;lt; 0.001). Patients assigned to HCTZ more frequently presented impaired renal function (increase in creatinine &amp;gt;26.5\u2005\u03bcmoL\/L or decrease in eGFR &amp;gt;50%; 46.5 vs. 17.2%; P &amp;lt; 0.001), but hypokalaemia and hypokalaemia were similar between groups. There were no differences in mortality or rehospitalizations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The addition of HCTZ to loop diuretic therapy improved diuretic response in patients with AHF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehac689","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T16:52:30Z","timestamp":1668099150000},"page":"411-421","source":"Crossref","is-referenced-by-count":321,"title":["Combining loop with thiazide diuretics for decompensated heart failure: the CLOROTIC trial"],"prefix":"10.1093","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7380-3475","authenticated-orcid":false,"given":"Joan Carles","family":"Trull\u00e0s","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Hospital d'Olot i comarcal de la Garrotxa , Girona, Av dels Pa\u00efsos Catalans, 86 , 17800 CA, Spain"},{"name":"Laboratori de Reparaci\u00f3 i Regeneraci\u00f3 Tissular (TR2Lab), Facultat de Medicina, Universitat de Vic\u2014Universitat Central de Catalunya , Carretera de Roda, 70, 08500 Vic, Barcelona, CA , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Morales-Rull","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Heart Failure Unit, Hospital Universitari Arnau de Villanova, Institut de Recerca Biom\u00e9dica (IRBLleida) , Avinguda Alcalde Rovira Roure, 80, 25198 Lleida , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Casado","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Universitario de Getafe , Carretera de Madrid - Toledo, Km 12,500, 28905 Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Carrera-Izquierdo","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Complejo Hospitalario de Soria , Paseo Santa B\u00e1rbara, 42005 Soria , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"S\u00e1nchez-Marteles","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Cl\u00ednico Universitario \u2018Lozano Blesa\u2019 , Calle de San Juan Bosco, 15, 50009 Zaragoza , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Conde-Martel","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Universitario de Gran Canaria Dr. Negr\u00edn , C. Pl. Barranco de la Ballena, s\/n, 35010 Las Palmas de Gran Canaria , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melit\u00f3n Francisco","family":"D\u00e1vila-Ramos","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Universitario Nuestra Se\u00f1ora de la Candelaria , Carretera Gerenal del Rosario, 145, 38010 Santa Cruz de Tenerife , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pau","family":"Ll\u00e1cer","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital de Manises , Avinguda de la Generalitat Valenciana, 50, 46940 Manises, Valencia , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prado","family":"Salamanca-Bautista","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Universitario Virgen Macarena, Universidad de Sevilla , Avenida Dr. Fedriani, 3, 41009 Sevilla , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"P\u00e9rez-Silvestre","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Consorcio Hospital General Universitario de Valencia , Avinguda de les Tres Creus, 2, 46014 Valencia , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1ngel","family":"Plas\u00edn","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Mollet University Hospital, Ronda dels Pinetons, 6, 08100 Mollet Del Valles , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Cerqueiro","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Universitario Lucus Augusti , R\u00faa Dr. Ulises Romero, 1, 27003 Lugo , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Gil","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, La Princesa University Hospital , Calle de Diego de Le\u00f3n, 62, 28006 Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3587-298X","authenticated-orcid":false,"given":"Francesc","family":"Formiga","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Universitari de Bellvitge, IDIBELL, Carrer de la Feixa Llarga, s\/n, 08907 L'Hospitalet de Llobregat , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Manzano","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, Universidad de Alcal\u00e1 , M-607, 9, 100, 28034 Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"CLOROTIC trial investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Lu\u00eds","family":"Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Sol\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Carrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Le\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanesa Garc\u00e9s","family":"Horna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Conde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta Hern\u00e1ndez","family":"Meneses","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melit\u00f3n Fco","family":"D\u00e1vila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Hern\u00e1ndez","family":"Carballo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Casado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pedro","family":"Zabaleta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pau Ll\u00e0cer","family":"Iborra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari Carmen Moreno","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan Carles","family":"Trull\u00e0s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Bisbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"del Prado Salamanca Bautista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d3scar Aramburu","family":"Bodas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds","family":"Manzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 P\u00e9rez","family":"Silvestre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1ngel","family":"Plas\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel Cerqueiro","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Chivite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Formiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Jordana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Villalonga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Inmaculada P\u00e1ez","family":"Rubio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M\u00aa Cepeda","family":"Rodrigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel Montero","family":"P\u00e9rez-Barquero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Muela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Mateos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Grau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arola","family":"Armengou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almudena","family":"Herrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal Quir\u00f3s","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"key":"2023020401275814700_ehac689-B1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s10741-007-9009-2","article-title":"Epidemiology of acute heart failure syndromes","volume":"12","author":"Alla","year":"2007","journal-title":"Heart Fail Rev"},{"key":"2023020401275814700_ehac689-B2","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nrcardio.2017.65","article-title":"Epidemiology of heart failure with preserved ejection fraction","volume":"14","author":"Dunlay","year":"2017","journal-title":"Nat Rev Cardiol"},{"key":"2023020401275814700_ehac689-B3","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"ESC guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur Heart J"},{"key":"2023020401275814700_ehac689-B4","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.jacc.2010.06.034","article-title":"Combination of loop diuretics with thiazide-type diuretics in heart failure","volume":"56","author":"Jentzer","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"2023020401275814700_ehac689-B5","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1056\/NEJMoa1005419","article-title":"Diuretic strategies in patients with acute decompensated heart failure","volume":"364","author":"Felker","year":"2011","journal-title":"N Engl J Med"},{"key":"2023020401275814700_ehac689-B6","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/ejhf.1369","article-title":"The use of diuretics in heart failure with congestion\u2014a position statement from the heart failure association of the European society of cardiology","volume":"21","author":"Mullens","year":"2019","journal-title":"Eur J Heart Fail"},{"key":"2023020401275814700_ehac689-B7","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.cardfail.2015.11.003","article-title":"Rationale and design of the \u201csafety and efficacy of the combination of loop with thiazide-type diuretics in patients with decompensated heart failure (CLOROTIC) trial:\u201d A double-blind, randomized, placebo-controlled study to determine the effect of combined diuretic therapy (loop diuretics with thiazide-type diuretics) among patients with decompensated heart failure","volume":"22","author":"Trull\u00e0s","year":"2016","journal-title":"J Card Fail"},{"key":"2023020401275814700_ehac689-B8","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1056\/NEJM199808063390607","article-title":"Diuretic therapy","volume":"339","author":"Brater","year":"1998","journal-title":"N Engl J Med"},{"key":"2023020401275814700_ehac689-B9","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1001\/jama.297.12.1332","article-title":"Short-term clinical effects of tolvaptan, an oral vasopressin antagonist, in patients hospitalized for heart failure: the EVEREST clinical Status trials","volume":"297","author":"Gheorghiade","year":"2007","journal-title":"JAMA"},{"key":"2023020401275814700_ehac689-B10","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1056\/NEJMoa1210357","article-title":"Ultrafiltration in decompensated heart failure with cardiorenal syndrome","volume":"367","author":"Bart","year":"2012","journal-title":"N Engl J Med"},{"key":"2023020401275814700_ehac689-B11","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jacc.2012.11.005","article-title":"Effect of serelaxin on cardiac, renal, and hepatic biomarkers in the relaxin in acute heart failure (RELAX-AHF) development program: correlation with outcomes","volume":"61","author":"Metra","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"2023020401275814700_ehac689-B12","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1136\/hrt.71.2.146","article-title":"Combination diuretic treatment in severe heart failure: a randomised controlled trial","volume":"71","author":"Channer","year":"1994","journal-title":"Br Heart J"},{"key":"2023020401275814700_ehac689-B13","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jchf.2019.09.012","article-title":"Diuretic strategies for loop diuretic resistance in acute heart failure: the 3\u2005T trial","volume":"8","author":"Cox","year":"2020","journal-title":"JACC Heart Fail"},{"key":"2023020401275814700_ehac689-B14","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1093\/oxfordjournals.eurheartj.a014805","article-title":"Combination of high-dose furosemide and hydrochlorothiazide in the treatment of refractory congestive heart failure","volume":"17","author":"Dormans","year":"1996","journal-title":"Eur Heart J"},{"key":"2023020401275814700_ehac689-B15","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1093\/eurheartj\/ehp253","article-title":"Effects of tolvaptan on dyspnoea relief from the EVEREST trials","volume":"30","author":"Pang","year":"2009","journal-title":"Eur Heart J"},{"key":"2023020401275814700_ehac689-B16","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/eurheartj\/eht386","article-title":"Renal impairment, worsening renal function, and outcome in patients with heart failure: an updated meta-analysis","volume":"35","author":"Damman","year":"2014","journal-title":"Eur Heart J"},{"key":"2023020401275814700_ehac689-B17","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/ejhf.2384","article-title":"Worsening renal function in acute heart failure in the context of diuretic response","volume":"24","author":"Emmens","year":"2022","journal-title":"Eur J Heart Fail"},{"key":"2023020401275814700_ehac689-B18","doi-asserted-by":"crossref","first-page":"e009149","DOI":"10.1161\/JAHA.118.009149","article-title":"Outcomes associated with a strategy of adjuvant metolazone or high-dose loop diuretics in acute decompensated heart failure: a propensity analysis","volume":"7","author":"Brisco-Bacik","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"2023020401275814700_ehac689-B19","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.jacc.2019.12.059","article-title":"Diuretic therapy for patients with heart failure: jACC state-of-the-art review","volume":"75","author":"Felker","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"2023020401275814700_ehac689-B20","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1161\/01.CIR.23.2.200","article-title":"Effects of reduced glomerular filtration rate on responsiveness to chlorothiazide and mercurial diuretics","volume":"23","author":"Reubi","year":"1961","journal-title":"Circulation"},{"key":"2023020401275814700_ehac689-B21","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1751-7176.2011.00564.x","article-title":"A pilot study comparing furosemide and hydrochlorothiazide in patients with hypertension and stage 4 or 5 chronic kidney disease","volume":"14","author":"Dussol","year":"2012","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"2023020401275814700_ehac689-B22","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1056\/NEJMoa2110730","article-title":"Chlorthalidone for hypertension in advanced chronic kidney disease","volume":"385","author":"Agarwal","year":"2021","journal-title":"N Engl J Med"},{"key":"2023020401275814700_ehac689-B23","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1056\/NEJMoa2203094","article-title":"Acetazolamide in acute decompensated heart failure with volume overload","volume":"387","author":"Mullens","year":"2022","journal-title":"N Engl J Med"},{"key":"2023020401275814700_ehac689-B24","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1002\/ehf2.13696","article-title":"Dose of furosemide before admission predicts diuretic efficiency and long-term prognosis in acute heart failure","volume":"9","author":"Bl\u00e1zquez-Bermejo","year":"2022","journal-title":"ESC Heart Fail"},{"key":"2023020401275814700_ehac689-B25","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s11739-018-02019-7","article-title":"Prevalence and outcome of diuretic resistance in heart failure","volume":"14","author":"Trull\u00e0s","year":"2019","journal-title":"Intern Emerg Med"}],"container-title":["European Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/44\/5\/411\/49088373\/ehac689.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/44\/5\/411\/49088373\/ehac689.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T20:28:22Z","timestamp":1675456102000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurheartj\/article\/44\/5\/411\/6845636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,24]]},"references-count":25,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,11,24]]},"published-print":{"date-parts":[[2023,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/eurheartj\/ehac689","relation":{},"ISSN":["0195-668X","1522-9645"],"issn-type":[{"value":"0195-668X","type":"print"},{"value":"1522-9645","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,2,1]]},"published":{"date-parts":[[2022,11,24]]}}}