{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T01:49:33Z","timestamp":1793152173186,"version":"4.5.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T00:00:00Z","timestamp":1669939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Heart and Stroke Foundation of Canada","award":["13-0003121"],"award-info":[{"award-number":["13-0003121"]}],"id":[{"id":"https:\/\/ror.org\/00qbpyp73","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Heart Rhythm"},{"DOI":"10.13039\/501100005247","name":"University of British Columbia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005247","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000245","name":"Michael Smith Foundation for Health Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000245","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Andr\u00e9 Chagnon"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Atrial tachyarrhythmia recurrence \u226530 s remains the primary endpoint of clinical trials; however, this definition has not been correlated with clinical outcomes or pathophysiological processes. This study sought to determine the atrial tachyarrhythmia duration and burden associated with meaningful clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>The time and duration of every atrial tachyarrhythmia episode recorded on implantable cardiac monitor were evaluated. Healthcare utilization and quality of life in the year following ablation were prospectively collected. Three hundred and forty-six patients provided 126 110 monitoring days. One-year freedom from recurrence increased with arrhythmia duration thresholds, from 52.6 (182\/346) to 93.3% (323\/346; P &amp;lt; 0.0001). Patients with atrial fibrillation (AF) recurrence limited to durations \u22641 h had rates of healthcare utilization comparable with patients free of recurrence, while patients with AF recurrences lasting &amp;gt;1 h had a relative risk for emergency department consultation of 3.2 [95% confidence interval (CI) 2.0\u20135.3], hospitalization of 5.3 (95% CI 2.9\u20139.6), and repeat ablation of 27.1 (95% CI 10.5\u201371.0). Patients with AF burden of \u22640.1% had rates of healthcare utilization comparable with patients free of recurrence, while patients with AF burden of &amp;gt;0.1% had a relative risk for emergency department consultation of 2.4 (95% CI 1.9\u20133.9), hospitalization of 6.8 (95% CI 3.6\u201313.0), cardioversion of 9.1 (95% CI 3.3\u201325.6), and repeat ablation of 21.8 (95% CI 9.2\u201352.2). Compared with patients free of recurrence, the disease-specific quality of life was significantly impaired with AF episode durations &amp;gt;24 h, or AF burdens &amp;gt;0.1%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AF recurrence, as defined by 30 s of arrhythmia, lacks clinical relevance. AF episode durations &amp;gt;1 h or burdens &amp;gt;0.1% were associated with increased rates of healthcare utilization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehac692","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T16:30:10Z","timestamp":1668443410000},"page":"765-776","source":"Crossref","is-referenced-by-count":118,"title":["Healthcare utilization and quality of life for atrial fibrillation burden: the CIRCA-DOSE study"],"prefix":"10.1093","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8493-5123","authenticated-orcid":false,"given":"Jason G","family":"Andrade","sequence":"first","affiliation":[{"name":"Montreal Heart Institute, Department of Medicine, Universit\u00e9 de Montr\u00e9al , 5000 Rue B\u00e9langer, Montr\u00e9al, Qu\u00e9bec H1T 1C8 , Canada"},{"name":"Department of Medicine, Vancouver General Hospital , 899 W 12th Ave, Vancouver, British Columbia V5Z 1M9 , Canada"},{"name":"Center for Cardiovascular Innovation , 2775 Laurel St, Vancouver, British Columbia V5Z 1M9 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8434-7076","authenticated-orcid":false,"given":"Marc W","family":"Deyell","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vancouver General Hospital , 899 W 12th Ave, Vancouver, British Columbia V5Z 1M9 , Canada"},{"name":"Center for Cardiovascular Innovation , 2775 Laurel St, Vancouver, British Columbia V5Z 1M9 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Macle","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute, Department of Medicine, Universit\u00e9 de Montr\u00e9al , 5000 Rue B\u00e9langer, Montr\u00e9al, Qu\u00e9bec H1T 1C8 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan S","family":"Steinberg","sequence":"additional","affiliation":[{"name":"Clinical Cardiovascular Research Center, University of Rochester School of Medicine and Dentistry , 601 Elmwood Ave, Rochester, NY 14642 , USA"},{"name":"SMG Arrhythmia Center, Summit Medical Group , 85 Woodland Rd, Short Hills, NJ 07078 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taya V","family":"Glotzer","sequence":"additional","affiliation":[{"name":"Hackensack Meridian School of Medicine; Hackensack University Medical Center , 30 Prospect Ave, Hackensack, NJ 07601 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel M","family":"Hawkins","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vancouver General Hospital , 899 W 12th Ave, Vancouver, British Columbia V5Z 1M9 , Canada"},{"name":"Center for Cardiovascular Innovation , 2775 Laurel St, Vancouver, British Columbia V5Z 1M9 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4059-3800","authenticated-orcid":false,"given":"Paul","family":"Khairy","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute, Department of Medicine, Universit\u00e9 de Montr\u00e9al , 5000 Rue B\u00e9langer, Montr\u00e9al, Qu\u00e9bec H1T 1C8 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute, Department of Medicine, Universit\u00e9 de Montr\u00e9al , 5000 Rue B\u00e9langer, Montr\u00e9al, Qu\u00e9bec H1T 1C8 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,12,2]]},"reference":[{"key":"2023030117462499100_","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/europace\/eum120","article-title":"HRS\/EHRA\/ECAS expert consensus statement on catheter and surgical 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