{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:12:17Z","timestamp":1784193137096,"version":"3.55.0"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"46","license":[{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA164751"],"award-info":[{"award-number":["R01CA164751"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Memorial Sloan Kettering Cancer Cente","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The most appropriate timing of exercise therapy to improve cardiorespiratory fitness (CRF) among patients initiating chemotherapy is not known. The effects of exercise therapy administered during, following, or during and following chemotherapy were examined in patients with breast cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Using a parallel-group randomized trial design, 158 inactive women with breast cancer initiating (neo)adjuvant chemotherapy were allocated to receive (1:1 ratio): usual care or one of three exercise regimens\u2014concurrent (during chemotherapy only), sequential (after chemotherapy only), or concurrent and sequential (continuous) (n = 39\/40 per group). Exercise consisted of treadmill walking three sessions\/week, 20\u201350 min at 55%\u2013100% of peak oxygen consumption (VO2peak) for \u224816 (concurrent, sequential) or \u224832 (continuous) consecutive weeks. VO2peak was evaluated at baseline (pre-treatment), immediately post-chemotherapy, and \u224816 weeks after chemotherapy. In intention-to-treat analysis, there was no difference in the primary endpoint of VO2peak change between concurrent exercise and usual care during chemotherapy vs. VO2peak change between sequential exercise and usual care after chemotherapy [overall difference, \u22120.88 mL O2\u00b7kg\u22121\u00b7min\u22121; 95% confidence interval (CI): \u22123.36, 1.59, P = 0.48]. In secondary analysis, continuous exercise, approximately equal to twice the length of the other regimens, was well-tolerated and the only strategy associated with significant improvements in VO2peak from baseline to post-intervention (1.74 mL O2\u00b7kg\u22121\u00b7min\u22121, P &amp;lt; 0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>There was no statistical difference in CRF improvement between concurrent vs. sequential exercise therapy relative to usual care in women with primary breast cancer. The promising tolerability and CRF benefit of \u224832 weeks of continuous exercise therapy warrant further evaluation in larger trials.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehad085","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T18:21:42Z","timestamp":1677003702000},"page":"4878-4889","source":"Crossref","is-referenced-by-count":42,"title":["Timing of exercise therapy when initiating adjuvant chemotherapy for breast cancer: a randomized trial"],"prefix":"10.1093","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4845-5800","authenticated-orcid":false,"given":"Jessica M","family":"Scott","sequence":"first","affiliation":[{"name":"Department of Medicine, Memorial Sloan Kettering Cancer Center , 1275 York Avenue, New York, NY 10065 , USA"},{"name":"Department of Medicine, Weill Cornell Medical College , 418 E 71st St, New York, NY 10021 , 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Avenue, New York, NY 10065 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly A","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Department of Medicine, Memorial Sloan Kettering Cancer Center , 1275 York Avenue, New York, NY 10065 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P","family":"Sasso","sequence":"additional","affiliation":[{"name":"School of Health and Exercise Sciences, University of British Columbia , 1147 Research Road, Kelowna, BC V1V 1V7 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7120-8285","authenticated-orcid":false,"given":"Anthony F","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Memorial Sloan Kettering Cancer Center , 1275 York Avenue, New York, NY 10065 , USA"},{"name":"Department of Medicine, Weill Cornell Medical College , 418 E 71st St, New York, NY 10021 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2660-8607","authenticated-orcid":false,"given":"Kylie A","family":"Rowed","sequence":"additional","affiliation":[{"name":"Department of Medicine, Memorial Sloan Kettering Cancer Center , 1275 York Avenue, New York, NY 10065 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline F","family":"Bromberg","sequence":"additional","affiliation":[{"name":"Department of Medicine, Memorial Sloan Kettering Cancer Center , 1275 York Avenue, New York, NY 10065 , USA"},{"name":"Department of Medicine, Weill Cornell Medical College , 418 E 71st St, New York, NY 10021 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany A","family":"Traina","sequence":"additional","affiliation":[{"name":"Department of Medicine, Memorial Sloan Kettering Cancer Center , 1275 York Avenue, New York, NY 10065 , USA"},{"name":"Department of Medicine, Weill Cornell Medical College , 418 E 71st St, New York, NY 10021 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayca","family":"Gucalp","sequence":"additional","affiliation":[{"name":"Department of Medicine, Memorial Sloan Kettering Cancer Center , 1275 York Avenue, New York, NY 10065 , USA"},{"name":"Department of Medicine, Weill Cornell Medical College , 418 E 71st St, New York, NY 10021 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel A","family":"Sanford","sequence":"additional","affiliation":[{"name":"Department of Medicine, Memorial Sloan Kettering Cancer Center , 1275 York Avenue, New York, NY 10065 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devika","family":"Gajria","sequence":"additional","affiliation":[{"name":"Department of Medicine, Memorial Sloan Kettering Cancer Center , 1275 York Avenue, New York, NY 10065 , USA"},{"name":"Department of Medicine, Weill Cornell Medical College , 418 E 71st St, New York, NY 10021 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Medicine, Weill Cornell Medical College , 418 E 71st St, New York, NY 10021 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria S","family":"Blinder","sequence":"additional","affiliation":[{"name":"Department of Medicine, Memorial Sloan Kettering Cancer Center , 1275 York Avenue, New York, NY 10065 , USA"},{"name":"Department of Medicine, Weill Cornell Medical College , 418 E 71st St, New York, NY 10021 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil D","family":"Eves","sequence":"additional","affiliation":[{"name":"School of Health and Exercise Sciences, University of British Columbia , 1147 Research Road, Kelowna, BC V1V 1V7 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7138-6404","authenticated-orcid":false,"given":"Jeffrey M","family":"Peppercorn","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Massachusetts General Hospital , 55 Fruit 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