{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T12:24:29Z","timestamp":1792844669063,"version":"4.5.0"},"reference-count":113,"publisher":"Oxford University Press (OUP)","issue":"21","license":[{"start":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T00:00:00Z","timestamp":1678924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pi-Cardia"},{"DOI":"10.13039\/100001316","name":"Abbott","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008497","name":"Boston Scientific","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006520","name":"Edwards","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Valvular heart disease (VHD) is the next epidemic in the cardiovascular field, affecting millions of people worldwide and having a major impact on health care systems. With aging of the population, the incidence and prevalence of VHD will continue to increase. However, VHD has not received the attention it deserves from both the public and policymakers. Despite important advances in the pathophysiology, natural history, management, and treatment of VHD including the development of transcatheter therapies, VHD remains underdiagnosed, identified late, and often undertreated with inequality in access to care and treatment options, and there is no medication that can prevent disease progression. The present review article discusses these gaps in the management of VHD and potential actions to undertake to improve the outcome of patients with VHD.<\/jats:p>","DOI":"10.1093\/eurheartj\/ehad121","type":"journal-article","created":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T15:30:14Z","timestamp":1676734214000},"page":"1862-1873","source":"Crossref","is-referenced-by-count":106,"title":["Unmet needs in valvular heart disease"],"prefix":"10.1093","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6278-5670","authenticated-orcid":false,"given":"David","family":"Messika-Zeitoun","sequence":"first","affiliation":[{"name":"Division of Cardiology, University of Ottawa Heart Institute , Ottawa, Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9542-8821","authenticated-orcid":false,"given":"Helmut","family":"Baumgartner","sequence":"additional","affiliation":[{"name":"Department of Cardiology III\u2014Adult Congenital and Valvular Heart Disease, University Hospital Muenster , Muenster , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian G","family":"Burwash","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Ottawa Heart Institute , Ottawa, Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9413-4891","authenticated-orcid":false,"given":"Alec","family":"Vahanian","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Bax","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center , Leiden , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3607-279X","authenticated-orcid":false,"given":"Philippe","family":"Pibarot","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Qu\u00e9bec Heart & Lung Institute\u2014Laval University , Qu\u00e9bec, Quebec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vince","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Cardiac surgery, University of Ottawa Heart Institute , Ottawa, Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Leon","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center and Cardiovascular Research Foundation , New York , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0910-5450","authenticated-orcid":false,"given":"Maurice","family":"Enriquez-Sarano","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute , Minneapolis, MN , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Mesana","sequence":"additional","affiliation":[{"name":"Division of Cardiac surgery, University of Ottawa Heart Institute , Ottawa , Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Iung","sequence":"additional","affiliation":[{"name":"Cardiology Department, Bichat Hospital, APHP, Universite\u0301 Paris Cit\u00e9 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,3,16]]},"reference":[{"key":"2023060100343525000_ehad121-B1","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1136\/heartjnl-2016-310894","article-title":"Epidemiology of valvular heart disease in a Swedish nationwide hospital-based register study","volume":"103","author":"Andell","year":"2017","journal-title":"Heart"},{"key":"2023060100343525000_ehad121-B2","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-012240","article-title":"Cohort profile: prevalence of valvular heart disease in community patients with suspected heart failure in UK","volume":"7","author":"Marciniak","year":"2017","journal-title":"BMJ Open"},{"key":"2023060100343525000_ehad121-B3","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","article-title":"Burden of valvular heart diseases: a population-based study","volume":"368","author":"Nkomo","year":"2006","journal-title":"Lancet"},{"key":"2023060100343525000_ehad121-B4","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"GBD-NHLBI-JACC global burden of cardiovascular diseases writing group. 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