{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:08:43Z","timestamp":1783008523229,"version":"3.54.5"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"34","license":[{"start":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:00:00Z","timestamp":1688601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The risk, characteristics, and outcome of out-of-hospital cardiac arrest (OHCA) in patients with congenital heart disease (CHD) remain scarcely investigated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>An epidemiological registry-based study was conducted. Using time-dependent Cox regression models fitted with a nested case\u2013control design, hazard ratios (HRs) with 95% confidence intervals of OHCA of presumed cardiac cause (2001\u201319) associated with simple, moderate, and severe CHD were calculated. Moreover, using multiple logistic regression, we investigated the association between pre-hospital OHCA characteristics and 30-day survival and compared 30-day survival in OHCA patients with and without CHD. Overall, 43 967 cases (105 with simple, 144 with moderate, and 53 with severe CHD) and 219 772 controls (median age 72 years, 68.2% male) were identified. Any type of CHD was found to be associated with higher rates of OHCA compared with the background population [simple CHD: HR 1.37 (1.08\u20131.70); moderate CHD: HR 1.64 (1.36\u20131.99); and severe CHD: HR 4.36 (3.01\u20136.30)]. Pre-hospital cardiopulmonary resuscitation and defibrillation were both associated with improved 30-day survival in patients with CHD, regardless of CHD severity. Among patients with OHCA, simple, moderate, and severe CHD had a similar likelihood of 30-day survival compared with no CHD [odds ratio 0.95 (0.53\u20131.69), 0.70 (0.43\u20131.14), and 0.68 (0.33\u20131.57), respectively].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>A higher risk of OHCA was found throughout the spectrum of CHD. Patients with and without CHD showed the same 30-day survival, which relies on the pre-hospital chain of survival, namely cardiopulmonary resuscitation and defibrillation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehad358","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T08:25:59Z","timestamp":1688631959000},"page":"3264-3274","source":"Crossref","is-referenced-by-count":9,"title":["Outcomes of out-of-hospital cardiac arrest in adult congenital heart disease: a Danish nationwide study"],"prefix":"10.1093","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0760-8372","authenticated-orcid":false,"given":"Carlo Alberto","family":"Barcella","sequence":"first","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Gentofte Hospitalsvej 1, 2900 Hellerup, Denmark"},{"name":"Department of Internal Medicine, Nyk\u00f8bing Falster Hospital, Fjordvej 15, 4800 Nyk\u00f8bing Falster, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M\u00f8lager","family":"Christensen","sequence":"additional","affiliation":[{"name":"The Danish Heart Foundation , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Idorn","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Rigshospitalet , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishan","family":"Mudalige","sequence":"additional","affiliation":[{"name":"Health Systems Intelligence Unit, Data Analytics, Reporting and Evaluation, Provincial Health Services Authority , British Columbia , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4838-2031","authenticated-orcid":false,"given":"Morten","family":"Malmborg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Gentofte Hospitalsvej 1, 2900 Hellerup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2284-7857","authenticated-orcid":false,"given":"Frederik","family":"Folke","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Gentofte Hospitalsvej 1, 2900 Hellerup, Denmark"},{"name":"Emergency Medical Services: The Capital Region of Denmark , Copenhagen , Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2892-6131","authenticated-orcid":false,"given":"Christian","family":"Torp-Pedersen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nordsjaellands Hospital , Hiller\u00f8d , Denmark"},{"name":"Department of Public Health, University of Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Gislason","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Gentofte Hospitalsvej 1, 2900 Hellerup, Denmark"},{"name":"The Danish Heart Foundation , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6022-1380","authenticated-orcid":false,"given":"Mohamad","family":"El-Chouli","sequence":"additional","affiliation":[{"name":"The Danish Heart Foundation , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,7,6]]},"reference":[{"key":"2023090701032649800_ehad358-B1","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.020375","article-title":"Time trends in simple congenital heart disease over 39 years: a Danish nationwide study","volume":"10","author":"El-Chouli","year":"2021","journal-title":"J Am 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