{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:14:53Z","timestamp":1791317693178,"version":"4.3.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T00:00:00Z","timestamp":1689379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute at the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"National Science Centre","doi-asserted-by":"publisher","award":["2021\/41\/B\/NZ5\/02630"],"award-info":[{"award-number":["2021\/41\/B\/NZ5\/02630"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"National Science Centre Poland","doi-asserted-by":"crossref","award":["2021\/43\/D\/NZ5\/02434"],"award-info":[{"award-number":["2021\/43\/D\/NZ5\/02434"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Transoesophageal echocardiography (TOE) is often performed before catheter ablation or cardioversion to rule out the presence of left atrial appendage thrombus (LAT) in patients on chronic oral anticoagulation (OAC), despite associated discomfort. A machine learning model [LAT-artificial intelligence (AI)] was developed to predict the presence of LAT based on clinical and transthoracic echocardiography (TTE) features.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Data from a 13-site prospective registry of patients who underwent TOE before cardioversion or catheter ablation were used. LAT-AI was trained to predict LAT using data from 12 sites (n = 2827) and tested externally in patients on chronic OAC from two sites (n = 1284). Areas under the receiver operating characteristic curve (AUC) of LAT-AI were compared with that of left ventricular ejection fraction (LVEF) and CHA2DS2-VASc score. A decision threshold allowing for a 99% negative predictive value was defined in the development cohort. A protocol where TOE in patients on chronic OAC is performed depending on the LAT-AI score was validated in the external cohort. In the external testing cohort, LAT was found in 5.5% of patients. LAT-AI achieved an AUC of 0.85 [95% confidence interval (CI): 0.82\u20130.89], outperforming LVEF (0.81, 95% CI 0.76\u20130.86, P &amp;lt; .0001) and CHA2DS2-VASc score (0.69, 95% CI: 0.63\u20130.7, P &amp;lt; .0001) in the entire external cohort. Based on the proposed protocol, 40% of patients on chronic OAC from the external cohort would safely avoid TOE.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>LAT-AI allows accurate prediction of LAT. A LAT-AI-based protocol could be used to guide the decision to perform TOE despite chronic OAC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehad431","type":"journal-article","created":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T15:26:16Z","timestamp":1689434776000},"page":"32-41","source":"Crossref","is-referenced-by-count":30,"title":["Artificial intelligence in detecting left atrial appendage thrombus by transthoracic echocardiography and clinical features: the Left Atrial Thrombus on Transoesophageal Echocardiography (LATTEE) registry"],"prefix":"10.1093","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5514-7750","authenticated-orcid":false,"given":"Konrad","family":"Pieszko","sequence":"first","affiliation":[{"name":"\u2018Club 30\u2019, Polish Cardiac Society , Poland"},{"name":"Department of Interventional Cardiology and Cardiac Surgery, University of Zielona Gora, Collegium Medicum , Zielona Gora , Poland"},{"name":"WSSP ZOZ Nowa Sol , Nowa Sol , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaros\u0142aw","family":"Hiczkiewicz","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology and Cardiac Surgery, University of Zielona Gora, Collegium Medicum , Zielona Gora , Poland"},{"name":"WSSP ZOZ Nowa Sol , Nowa Sol , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"\u0141ojewska","sequence":"additional","affiliation":[{"name":"WSSP ZOZ Nowa Sol , Nowa Sol , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8997-6568","authenticated-orcid":false,"given":"Beata","family":"Uzi\u0119b\u0142o-\u017byczkowska","sequence":"additional","affiliation":[{"name":"\u2018Club 30\u2019, Polish Cardiac Society , Poland"},{"name":"Department of Cardiology and Internal Diseases, Military Institute of Medicine , Warsaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1909-0993","authenticated-orcid":false,"given":"Pawe\u0142","family":"Krzesi\u0144ski","sequence":"additional","affiliation":[{"name":"\u2018Club 30\u2019, Polish Cardiac Society , Poland"},{"name":"Department of Cardiology and Internal Diseases, Military Institute of Medicine , Warsaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4619-9062","authenticated-orcid":false,"given":"Monika","family":"Gawa\u0142ko","sequence":"additional","affiliation":[{"name":"\u2018Club 30\u2019, Polish Cardiac Society , Poland"},{"name":"First Department of Cardiology, Medical University of Warsaw , Warsaw , Poland"},{"name":"Department of Cardiology, Maastricht University Medical Centre and Cardiovascular Research Institute Maastricht , Maastricht , The Netherlands"},{"name":"Institute of Pharmacology, West German Heart and Vascular Centre, University Duisburg-Essen , Essen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2982-3508","authenticated-orcid":false,"given":"Monika","family":"Budnik","sequence":"additional","affiliation":[{"name":"\u2018Club 30\u2019, Polish Cardiac Society , Poland"},{"name":"First Department of Cardiology, Medical University of Warsaw , Warsaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0121-4487","authenticated-orcid":false,"given":"Katarzyna","family":"Starzyk","sequence":"additional","affiliation":[{"name":"1st Clinic of Cardiology and Electrotherapy, Swietokrzyskie Cardiology Centre , Kielce , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Wo\u017cakowska-Kap\u0142on","sequence":"additional","affiliation":[{"name":"1st Clinic of Cardiology and Electrotherapy, Swietokrzyskie Cardiology Centre , Kielce , 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