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This study aimed to seek assessing the vegetation cut-off size as predictor of EE or 30-day mortality for LSIE and to determine risk predictors of these outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The European Society of Cardiology EURObservational Research Programme European Infective Endocarditis is a prospective, multicentre registry including patients with definite or possible IE throughout 2016\u201318. Cox multivariable logistic regression analysis was performed to assess variables associated with EE or 30-day mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were 2171 patients with LSIE (women 31.5%). Among these affected patients, 459 (21.1%) had a new EE or died in 30 days. The cut-off value of vegetation size for predicting EEs or 30-day mortality was &amp;gt;10 mm [hazard ratio (HR) 1.38, 95% confidence interval (CI) 1.13\u20131.69, P = .0015]. Other adjusted predictors of risk of EE or death were as follows: EE on admission (HR 1.89, 95% CI 1.54\u20132.33, P &amp;lt; .0001), history of heart failure (HR 1.53, 95% CI 1.21\u20131.93, P = .0004), creatinine &amp;gt;2 mg\/dL (HR 1.59, 95% CI 1.25\u20132.03, P = .0002), Staphylococcus aureus (HR 1.36, 95% CI 1.08\u20131.70, P = .008), congestive heart failure (HR 1.40, 95% CI 1.12\u20131.75, P = .003), presence of haemorrhagic stroke (HR 4.57, 95% CI 3.08\u20136.79, P &amp;lt; .0001), alcohol abuse (HR 1.45, 95% CI 1.04\u20132.03, P = .03), presence of cardiogenic shock (HR 2.07, 95% CI 1.29\u20133.34, P = .003), and not performing left surgery (HR 1.30 95% CI 1.05\u20131.61, P = .016) (C-statistic = .68).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Prognosis after LSIE is determined by multiple factors, including vegetation size.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\u00a0<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehad507","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T17:31:14Z","timestamp":1690306274000},"page":"4566-4575","source":"Crossref","is-referenced-by-count":46,"title":["Predictors of embolism and death in left-sided infective endocarditis: the European Society of Cardiology EURObservational Research Programme European Infective Endocarditis registry"],"prefix":"10.1093","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3939-5559","authenticated-orcid":false,"given":"Antonia","family":"Sambola","sequence":"first","affiliation":[{"name":"Department of Cardiology and Research Institute, Cardiac Intensive Care Unit, University Hospital Valld\u2019Hebron, Universitat Aut\u00f2noma, CIBER Cardiovascular Diseases (CIBER-CV) , P\u00b0 Vall d\u2019Hebron, 119-129, Barcelona 08035 , 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