{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T13:06:49Z","timestamp":1794488809799,"version":"4.9.1"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"37","license":[{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,1]]},"DOI":"10.1093\/eurheartj\/ehad518","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T11:38:56Z","timestamp":1693481936000},"page":"3655-3657","source":"Crossref","is-referenced-by-count":13,"title":["Beta-blockers in non-obstructive hypertrophic cardiomyopathy: time to ease the heart rate restriction?"],"prefix":"10.1093","volume":"44","author":[{"given":"Adaya","family":"Weissler-Snir","sequence":"first","affiliation":[{"name":"Hartford HealthCare, Heart and Vascular Institute , 80 Seymour St, Hartford, CT 06106 , USA"},{"name":"Department of Medicine, University of Connecticut Farmington , CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Rakowski","sequence":"additional","affiliation":[{"name":"The Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, Toronto General Hospital , 585 University Ave, Toronto, ON M5G 2N2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4398-5642","authenticated-orcid":false,"given":"Markus","family":"Meyer","sequence":"additional","affiliation":[{"name":"Lillehei Heart Institute, Department of Medicine, University of Minnesota , 2231 6th Street SE, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,8,31]]},"reference":[{"key":"2023100120181621300_ehad518-B1","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1016\/j.jacc.2020.08.044","article-title":"2020 AHA\/ACC guideline for the diagnosis and treatment of patients with hypertrophic cardiomyopathy: executive summary: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"76","author":"Ommen","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"2023100120181621300_ehad518-B2","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.amjcard.2015.01.548","article-title":"Exercise heart rates in patients with hypertrophic cardiomyopathy","volume":"115","author":"Luo","year":"2015","journal-title":"Am J Cardiol"},{"key":"2023100120181621300_ehad518-B3","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2020.580419","article-title":"Effects of oral drugs on coronary microvascular function in patients without significant stenosis of epicardial coronary arteries: a systematic review and meta-analysis of coronary flow reserve","volume":"7","author":"Yong","year":"2020","journal-title":"Front Cardiovasc Med"},{"key":"2023100120181621300_ehad518-B4","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1136\/hrt.2006.099416","article-title":"Evidence that pharmacological strategies lack efficacy for the prevention of sudden death in hypertrophic cardiomyopathy","volume":"93","author":"Melacini","year":"2007","journal-title":"Heart"},{"key":"2023100120181621300_ehad518-B5","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1161\/01.CIR.35.5.847","article-title":"Amelioration of angina pectoris in idiopathic hypertrophic subaortic stenosis with betaadrenergic blockade","volume":"35","author":"Cohen","year":"1967","journal-title":"Circulation"},{"key":"2023100120181621300_ehad518-B6","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/j.jacc.2022.02.024","article-title":"Effects of metoprolol on exercise hemodynamics in patients with obstructive hypertrophic cardiomyopathy","volume":"79","author":"Dybro","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"2023100120181621300_ehad518-B7","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1016\/j.jacc.2021.07.065","article-title":"Randomized trial of metoprolol in patients with obstructive hypertrophic cardiomyopathy","volume":"78","author":"Dybro","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"2023100120181621300_ehad518-B8","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/ejhf.2737","article-title":"Effect of beta-blocker therapy on the response to mavacamten in patients with symptomatic obstructive hypertrophic cardiomyopathy","volume":"25","author":"Wheeler","year":"2023","journal-title":"Eur J Heart Fail"},{"key":"2023100120181621300_ehad518-B9","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1161\/01.CIR.79.5.1052","article-title":"Verapamil prevents silent myocardial perfusion abnormalities during exercise in asymptomatic patients with hypertrophic cardiomyopathy","volume":"79","author":"Udelson","year":"1989","journal-title":"Circulation"},{"key":"2023100120181621300_ehad518-B10","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.119.006213","article-title":"Heart rate and heart failure with preserved ejection fraction","volume":"12","author":"Meyer","year":"2019","journal-title":"Circ Heart Fail"},{"key":"2023100120181621300_ehad518-B11","doi-asserted-by":"crossref","first-page":"e1916598","DOI":"10.1001\/jamanetworkopen.2019.16598","article-title":"Association of \u03b2-blocker use with heart failure hospitalizations and cardiovascular disease mortality among patients with heart failure with a preserved ejection fraction: a secondary analysis of the TOPCAT trial","volume":"2","author":"Silverman","year":"2019","journal-title":"JAMA Netw Open"},{"key":"2023100120181621300_ehad518-B12","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1016\/j.jacc.2021.08.073","article-title":"Effect of \u03b2-blocker withdrawal on functional capacity in heart failure and preserved ejection fraction","volume":"78","author":"Palau","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"2023100120181621300_ehad518-B13","article-title":"Lack of association between neurohormonal blockade and survival in transthyretin cardiac amyloidosis","volume":"10","author":"Cheng","year":"2021","journal-title":"J Am Heart Assoc [Internet]"},{"key":"2023100120181621300_ehad518-B14","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1056\/NEJMoa1406430","article-title":"Ivabradine in stable coronary artery disease without clinical heart failure","volume":"371","author":"Fox","year":"2014","journal-title":"N Engl J Med"},{"key":"2023100120181621300_ehad518-B15","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1001\/jamacardio.2022.5320","article-title":"Effect of personalized accelerated pacing on quality of life, physical activity, and atrial fibrillation in patients with preclinical and overt heart failure with preserved ejection fraction","volume":"8","author":"Infeld","year":"2023","journal-title":"JAMA Cardiol"},{"key":"2023100120181621300_ehad518-B16","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1093\/eurheartj\/ehad347","article-title":"Conventional heart failure therapy in cardiac ATTR amyloidosis","volume":"44","author":"Ioannou","year":"2023","journal-title":"Eur Heart J"}],"container-title":["European Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/44\/37\/3655\/51823710\/ehad518.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/44\/37\/3655\/51823710\/ehad518.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T20:23:11Z","timestamp":1696191791000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurheartj\/article\/44\/37\/3655\/7256779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,31]]},"references-count":16,"journal-issue":{"issue":"37","published-online":{"date-parts":[[2023,8,31]]},"published-print":{"date-parts":[[2023,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/eurheartj\/ehad518","relation":{},"ISSN":["0195-668X","1522-9645"],"issn-type":[{"value":"0195-668X","type":"print"},{"value":"1522-9645","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,10,1]]},"published":{"date-parts":[[2023,8,31]]}}}