{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:04:42Z","timestamp":1792785882368,"version":"4.5.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T00:00:00Z","timestamp":1692921600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000222","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","award":["G-13-0003121"],"award-info":[{"award-number":["G-13-0003121"]}],"id":[{"id":"10.13039\/501100000222","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000245","name":"Michael Smith Foundation for Health Research Scholar Award","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000245","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Andr\u00e9 Chagnon research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Atrial fibrillation (AF) is a chronic progressive disorder. Persistent forms of AF are associated with increased rates of thromboembolism, heart failure, and death. Catheter ablation modifies the pathogenic mechanism of AF progression. No randomized studies have evaluated the impact of the ablation energy on progression to persistent atrial tachyarrhythmia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Three hundred forty-six patients with drug-refractory paroxysmal AF were enrolled and randomly assigned to contact-force\u2013guided RF ablation (CF-RF ablation, 115), 4 min cryoballoon ablation (CRYO-4, 115), or 2 min cryoballoon ablation (CRYO-2, 116). Implantable cardiac monitors placed at study entry were used for follow-up. The main outcome was the first episode of persistent atrial tachyarrhythmia. Secondary outcomes included atrial tachyarrhythmia recurrence and arrhythmia burden on the implantable monitor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At a median of 944.0 (interquartile range [IQR], 612.5\u20131104) days, 0 of 115 patients (0.0%) randomly assigned to CF-RF, 8 of 115 patients (7.0%) assigned to CRYO-4, and 5 of 116 patients (4.3%) assigned to CRYO-2 experienced an episode of persistent atrial tachyarrhythmia (P = .03). A documented recurrence of any atrial tachyarrhythmia \u226530 s occurred in 56.5%, 53.9%, and 62.9% of those randomized to CF-RF, CRYO-4, and CRYO-2, respectively; P = .65. Compared with that of the pre-ablation monitoring period, AF burden was reduced by a median of 99.5% (IQR 94.0%, 100.0%) with CF-RF, 99.9% (IQR 93.3%\u2013100.0%) with CRYO-4, and 99.1%% (IQR 87.0%\u2013100.0%) with CRYO-2 (P = .38).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Catheter ablation of paroxysmal AF using radiofrequency energy was associated with fewer patients developing persistent AF on follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehad572","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T16:33:30Z","timestamp":1692722010000},"page":"510-518","source":"Crossref","is-referenced-by-count":77,"title":["Atrial fibrillation progression after cryoablation vs. radiofrequency ablation: the CIRCA-DOSE trial"],"prefix":"10.1093","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8493-5123","authenticated-orcid":false,"given":"Jason G","family":"Andrade","sequence":"first","affiliation":[{"name":"Department of Medicine, University of British Columbia , 2775 Laurel St 10th Floor, Vancouver, BC V5Z 1M9 , Canada"},{"name":"Center for Cardiovascular Innovation , 2775 Laurel St 9th Floor, Vancouver, BC V5Z 1M9 , Canada"},{"name":"Montreal Heart Institute, Department of Medicine, Universit\u00e9 de Montr\u00e9al , 5000 Rue B\u00e9langer, Montr\u00e9al, QC H1T 1C8 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8434-7076","authenticated-orcid":false,"given":"Marc W","family":"Deyell","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Innovation , 2775 Laurel St 9th Floor, Vancouver, BC V5Z 1M9 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4059-3800","authenticated-orcid":false,"given":"Paul","family":"Khairy","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute, Department of Medicine, Universit\u00e9 de Montr\u00e9al , 5000 Rue B\u00e9langer, Montr\u00e9al, QC H1T 1C8 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9861-9351","authenticated-orcid":false,"given":"Jean","family":"Champagne","sequence":"additional","affiliation":[{"name":"Department of Medicine, Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec , 2725 Ch Ste-Foy, Qu\u00e9bec, QC G1V 4G5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Leong-Sit","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Western Ontario , 1151 Richmond St, London, ON N6A 5C1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Novak","sequence":"additional","affiliation":[{"name":"Department of Medicine, Royal Jubilee Hospital , 1952 Bay St, Victoria, BC V8R 1J8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Sterns","sequence":"additional","affiliation":[{"name":"Department of Medicine, Royal Jubilee Hospital , 1952 Bay St, Victoria, BC V8R 1J8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Francois","family":"Roux","sequence":"additional","affiliation":[{"name":"Department of Medicine, Centre Hospitalier Universitaire de Sherbrooke , 580 Rue Bowen S, Sherbrooke, QC J1G 2E8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Sapp","sequence":"additional","affiliation":[{"name":"Queen Elizabeth II Health Sciences Centre, Dalhousie University , 1276 South Park Street, Halifax, Nova Scotia, B3H 2Y9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Bennett","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Innovation , 2775 Laurel St 9th Floor, Vancouver, BC V5Z 1M9 , Canada"},{"name":"Montreal Heart Institute, Department of Medicine, Universit\u00e9 de Montr\u00e9al , 5000 Rue B\u00e9langer, Montr\u00e9al, QC H1T 1C8 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1675-8225","authenticated-orcid":false,"given":"Matthew","family":"Bennett","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Innovation , 2775 Laurel St 9th Floor, Vancouver, BC V5Z 1M9 , Canada"},{"name":"Montreal Heart Institute, Department of Medicine, Universit\u00e9 de Montr\u00e9al , 5000 Rue B\u00e9langer, Montr\u00e9al, QC H1T 1C8 , 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