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This study aimed to test the association of CHIP with new-onset arrhythmias.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>UK Biobank participants without prevalent arrhythmias were included. Co-primary study outcomes were supraventricular arrhythmias, bradyarrhythmias, and ventricular arrhythmias. Secondary outcomes were cardiac arrest, atrial fibrillation, and any arrhythmia. Associations of any CHIP [variant allele fraction (VAF) \u2265 2%], large CHIP (VAF \u226510%), and gene-specific CHIP subtypes with incident arrhythmias were evaluated using multivariable-adjusted Cox regression. Associations of CHIP with myocardial interstitial fibrosis [T1 measured using cardiac magnetic resonance (CMR)] were also tested.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This study included 410 702 participants [CHIP: n = 13 892 (3.4%); large CHIP: n = 9191 (2.2%)]. Any and large CHIP were associated with multi-variable-adjusted hazard ratios of 1.11 [95% confidence interval (CI) 1.04\u20131.18; P = .001] and 1.13 (95% CI 1.05\u20131.22; P = .001) for supraventricular arrhythmias, 1.09 (95% CI 1.01\u20131.19; P = .031) and 1.13 (95% CI 1.03\u20131.25; P = .011) for bradyarrhythmias, and 1.16 (95% CI, 1.00\u20131.34; P = .049) and 1.22 (95% CI 1.03\u20131.45; P = .021) for ventricular arrhythmias, respectively. Associations were independent of coronary artery disease and heart failure. Associations were also heterogeneous across arrhythmia subtypes and strongest for cardiac arrest. Gene-specific analyses revealed an increased risk of arrhythmias across driver genes other than DNMT3A. Large CHIP was associated with 1.31-fold odds (95% CI 1.07\u20131.59; P = .009) of being in the top quintile of myocardial fibrosis by CMR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CHIP may represent a novel risk factor for incident arrhythmias, indicating a potential target for modulation towards arrhythmia prevention and treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehad670","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T16:47:24Z","timestamp":1695746844000},"page":"791-805","source":"Crossref","is-referenced-by-count":87,"title":["Clonal haematopoiesis of indeterminate potential predicts incident cardiac 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,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7199-299X","authenticated-orcid":false,"given":"Victor","family":"Nauffal","sequence":"additional","affiliation":[{"name":"Program in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT , 75 Ames St., Cambridge, MA 02142 ,","place":["USA"]},{"name":"Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women\u2019s Hospital , Boston, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Mi Jemma","family":"Cho","sequence":"additional","affiliation":[{"name":"Program in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT , 75 Ames St., Cambridge, MA 02142 ,","place":["USA"]},{"name":"Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital , 185 Cambridge St., Boston, MA 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