{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:40:04Z","timestamp":1793194804148,"version":"4.5.0"},"reference-count":166,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T00:00:00Z","timestamp":1699228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002996","name":"Dutch Heart Foundation","doi-asserted-by":"crossref","award":["2020T020"],"award-info":[{"award-number":["2020T020"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007661","name":"NIG","doi-asserted-by":"publisher","award":["R35HL144976"],"award-info":[{"award-number":["R35HL144976"]}],"id":[{"id":"10.13039\/501100007661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The leading cause of heart disease in developed countries is coronary atherosclerosis, which is not simply a result of ageing but a chronic inflammatory process that can lead to acute clinical events upon atherosclerotic plaque rupture or erosion and arterial thrombus formation. The composition and location of atherosclerotic plaques determine the phenotype of the lesion and whether it is more likely to rupture or to erode. Although plaque rupture and erosion both initiate platelet activation on the exposed vascular surface, the contribution of platelets to thrombus formation differs between the two phenotypes. In this review, plaque phenotype is discussed in relation to thrombus composition, and an overview of important mediators (haemodynamics, matrix components, and soluble factors) in plaque-induced platelet activation is given. As thrombus formation on disrupted plaques does not necessarily result in complete vessel occlusion, plaque healing can occur. Therefore, the latest findings on plaque healing and the potential role of platelets in this process are summarized. Finally, the clinical need for more effective antithrombotic agents is highlighted.<\/jats:p>","DOI":"10.1093\/eurheartj\/ehad720","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T01:50:18Z","timestamp":1699494618000},"page":"18-31","source":"Crossref","is-referenced-by-count":134,"title":["Platelet biology and function: plaque erosion vs. rupture"],"prefix":"10.1093","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4255-8224","authenticated-orcid":false,"given":"Constance C F M J","family":"Baaten","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University , Universiteitssingel 50, 6229 ER, Maastricht , the Netherlands"},{"name":"Institute for Molecular Cardiovascular Research (IMCAR), University Hospital RWTH Aachen , Aachen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8575-5936","authenticated-orcid":false,"given":"Magdolna","family":"Nagy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University , Universiteitssingel 50, 6229 ER, Maastricht , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1211-8861","authenticated-orcid":false,"given":"Wolfgang","family":"Bergmeier","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, School of Medicine, University of North Caroline at Chapel Hill , Chapel Hill, NC , USA"},{"name":"Blood Research Center, School of Medicine, University of North Caroline at Chapel Hill , Chapel Hill, NC , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3858-334X","authenticated-orcid":false,"given":"Henri M H","family":"Spronk","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University , Universiteitssingel 50, 6229 ER, Maastricht , the Netherlands"},{"name":"Department of Internal Medicine, Maastricht University Medical Center+ , Maastricht , the Netherlands"},{"name":"Thrombosis Expertise Center, Heart+ Vascular Center, Maastricht University Medical Center+ , P. Debeyelaan 25, Maastricht , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6532-2583","authenticated-orcid":false,"given":"Paola E J","family":"van der Meijden","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University , Universiteitssingel 50, 6229 ER, Maastricht , the Netherlands"},{"name":"Thrombosis Expertise Center, Heart+ Vascular Center, Maastricht University Medical Center+ , P. Debeyelaan 25, Maastricht , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,11,6]]},"reference":[{"key":"2023123123555472100_ehad720-B1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41569-018-0110-0","article-title":"Platelet biology and functions: new concepts and clinical perspectives","volume":"16","author":"van der Meijden","year":"2019","journal-title":"Nat Rev Cardiol"},{"key":"2023123123555472100_ehad720-B2","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1046\/j.1365-2362.1996.150293.x","article-title":"Role of catecholamines in platelet function: pathophysiological and clinical significance","volume":"26","author":"Anfossi","year":"1996","journal-title":"Eur J Clin Invest"},{"key":"2023123123555472100_ehad720-B3","doi-asserted-by":"crossref","first-page":"6204","DOI":"10.1182\/bloodadvances.2020002843","article-title":"Lung megakaryocytes display distinct transcriptional and phenotypic properties","volume":"4","author":"Yeung","year":"2020","journal-title":"Blood Adv"},{"key":"2023123123555472100_ehad720-B4","doi-asserted-by":"publisher","first-page":"e137377","DOI":"10.1172\/JCI137377","article-title":"Lung megakaryocytes are immune modulatory cells","volume":"131","author":"Pariser","year":"2021","journal-title":"J Clin Invest"},{"key":"2023123123555472100_ehad720-B5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1152\/physrev.00016.2011","article-title":"New fundamentals in hemostasis","volume":"93","author":"Versteeg","year":"2013","journal-title":"Physiol Rev"},{"key":"2023123123555472100_ehad720-B6","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1161\/01.CIR.92.5.1355","article-title":"A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association","volume":"92","author":"Stary","year":"1995","journal-title":"Circulation"},{"key":"2023123123555472100_ehad720-B7","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1160\/TH11-08-0592","article-title":"Platelets in atherosclerosis","volume":"106","author":"Lievens","year":"2011","journal-title":"Thromb Haemost"},{"key":"2023123123555472100_ehad720-B8","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.3390\/cells11061014","article-title":"Platelets, a key cell in inflammation and atherosclerosis progression","volume":"11","author":"Huilcaman","year":"2022","journal-title":"Cells"},{"key":"2023123123555472100_ehad720-B9","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/bjh.14653","article-title":"Platelets: much more than bricks in a breached wall","volume":"178","author":"Mancuso","year":"2017","journal-title":"Br J Haematol"},{"key":"2023123123555472100_ehad720-B10","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/s41586-021-03392-8","article-title":"The changing landscape of atherosclerosis","volume":"592","author":"Libby","year":"2021","journal-title":"Nature"},{"key":"2023123123555472100_ehad720-B11","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1161\/CIRCRESAHA.114.302721","article-title":"Mechanisms of plaque formation and rupture","volume":"114","author":"Bentzon","year":"2014","journal-title":"Circ Res"},{"key":"2023123123555472100_ehad720-B12","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nature01323","article-title":"Inflammation in atherosclerosis","volume":"420","author":"Libby","year":"2002","journal-title":"Nature"},{"key":"2023123123555472100_ehad720-B13","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1161\/01.CIR.89.1.36","article-title":"Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology","volume":"89","author":"van der Wal","year":"1994","journal-title":"Circulation"},{"key":"2023123123555472100_ehad720-B14","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1160\/th15-09-0765","article-title":"Endothelial erosion of plaques as a substrate for coronary thrombosis","volume":"115","author":"White","year":"2016","journal-title":"Thromb Haemost"},{"key":"2023123123555472100_ehad720-B15","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1161\/01.CIR.93.7.1354","article-title":"Coronary plaque erosion without rupture into a lipid core. A frequent cause of coronary thrombosis in sudden coronary death","volume":"93","author":"Farb","year":"1996","journal-title":"Circulation"},{"key":"2023123123555472100_ehad720-B16","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1172\/JCI117619","article-title":"Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques","volume":"94","author":"Galis","year":"1994","journal-title":"J Clin Invest"},{"key":"2023123123555472100_ehad720-B17","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1161\/01.ATV.0000034021.92658.4C","article-title":"Differential accumulation of proteoglycans and hyaluronan in culprit lesions: insights into plaque erosion","volume":"22","author":"Kolodgie","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2023123123555472100_ehad720-B18","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/00041433-200410000-00012","article-title":"The accumulation of specific types of proteoglycans in eroded plaques: a role in coronary thrombosis in the absence of rupture","volume":"15","author":"Kolodgie","year":"2004","journal-title":"Curr Opin Lipidol"},{"key":"2023123123555472100_ehad720-B19","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1161\/CIRCRESAHA.117.312494","article-title":"Roles of PAD4 and NETosis in experimental atherosclerosis and arterial injury: implications for superficial erosion","volume":"123","author":"Franck","year":"2018","journal-title":"Circ Res"},{"key":"2023123123555472100_ehad720-B20","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1093\/eurheartj\/ehv044","article-title":"TLR2 And neutrophils potentiate endothelial stress, apoptosis and detachment: implications for superficial erosion","volume":"36","author":"Quillard","year":"2015","journal-title":"Eur Heart J"},{"key":"2023123123555472100_ehad720-B21","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1055\/s-0038-1641749","article-title":"Neutrophil extracellular traps participate in all different types of thrombotic and haemorrhagic complications of coronary atherosclerosis","volume":"118","author":"Pertiwi","year":"2018","journal-title":"Thromb Haemost"},{"key":"2023123123555472100_ehad720-B22","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1161\/ATVBAHA.118.311150","article-title":"Neutrophil extracellular traps induce endothelial cell activation and tissue factor production through interleukin-1\u03b1 and cathepsin G","volume":"38","author":"Folco","year":"2018","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2023123123555472100_ehad720-B23","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/s41569-021-00542-3","article-title":"Plaque erosion and acute coronary syndromes: phenotype, molecular characteristics and future directions","volume":"18","author":"Fahed","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"2023123123555472100_ehad720-B24","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.atherosclerosis.2020.10.016","article-title":"New prediction tools and treatment for ACS patients with plaque erosion","volume":"318","author":"Vergallo","year":"2021","journal-title":"Atherosclerosis"},{"key":"2023123123555472100_ehad720-B25","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1093\/eurheartj\/ehv029","article-title":"Plaque rupture and intact fibrous cap assessed by optical coherence tomography portend different outcomes in patients with acute coronary syndrome","volume":"36","author":"Niccoli","year":"2015","journal-title":"Eur Heart J"},{"key":"2023123123555472100_ehad720-B26","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1038\/s44161-022-00171-0","article-title":"Transcriptomic-based clustering of human atherosclerotic plaques identifies subgroups with different underlying biology and clinical presentation","volume":"1","author":"Mokry","year":"2022","journal-title":"Nat Cardiovasc Res"},{"key":"2023123123555472100_ehad720-B27","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1038\/s41591-019-0590-4","article-title":"Single-cell immune landscape of human atherosclerotic plaques","volume":"25","author":"Fernandez","year":"2019","journal-title":"Nat Med"},{"key":"2023123123555472100_ehad720-B28","doi-asserted-by":"crossref","first-page":"1085468","DOI":"10.3389\/fimmu.2022.1085468","article-title":"Single-cell atlas reveals different immune environments between stable and vulnerable atherosclerotic plaques","volume":"13","author":"Ge","year":"2022","journal-title":"Front Immunol"},{"key":"2023123123555472100_ehad720-B29","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1161\/CIRCRESAHA.120.316770","article-title":"Microanatomy of the human atherosclerotic plaque by single-cell transcriptomics","volume":"127","author":"Depuydt","year":"2020","journal-title":"Circ Res"},{"key":"2023123123555472100_ehad720-B30","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1093\/eurheartj\/ehab920","article-title":"Interferon regulatory factor-5-dependent CD11c+ macrophages contribute to the formation of rupture-prone atherosclerotic plaques","volume":"43","author":"Edsfeldt","year":"2022","journal-title":"Eur Heart J"},{"key":"2023123123555472100_ehad720-B31","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/2231159a0","article-title":"Arterial wall shear and distribution of early atheroma in man","volume":"223","author":"Caro","year":"1969","journal-title":"Nature"},{"key":"2023123123555472100_ehad720-B32","doi-asserted-by":"crossref","first-page":"e012322","DOI":"10.1161\/JAHA.119.012322","article-title":"Clinical and laboratory predictors for plaque erosion in patients with acute coronary syndromes","volume":"8","author":"Yamamoto","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"2023123123555472100_ehad720-B33","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1093\/eurheartj\/ehy101","article-title":"In vivo predictors of plaque erosion in patients with ST-segment elevation myocardial infarction: a clinical, angiographical, and intravascular optical coherence tomography study","volume":"39","author":"Dai","year":"2018","journal-title":"Eur Heart J"},{"key":"2023123123555472100_ehad720-B34","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s10554-020-02021-1","article-title":"Systemic and local factors associated with reduced thrombolysis in myocardial infarction flow in ST-segment elevation myocardial infarction patients with plaque erosion detected by intravascular optical coherence tomography","volume":"37","author":"Wang","year":"2021","journal-title":"Int J Cardiovasc Imaging"},{"key":"2023123123555472100_ehad720-B35","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1016\/j.jcmg.2017.04.017","article-title":"Plaque rupture in coronary atherosclerosis is associated with increased plaque structural stress","volume":"10","author":"Costopoulos","year":"2017","journal-title":"JACC Cardiovasc Imaging"},{"key":"2023123123555472100_ehad720-B36","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jacc.2009.09.007","article-title":"Relationship of thrombus healing to underlying plaque morphology in sudden coronary death","volume":"55","author":"Kramer","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"2023123123555472100_ehad720-B37","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.atherosclerosis.2015.01.017","article-title":"Sex differences in coronary artery disease: pathological observations","volume":"239","author":"Yahagi","year":"2015","journal-title":"Atherosclerosis"},{"key":"2023123123555472100_ehad720-B38","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s11883-022-00980-5","article-title":"Sex differences in coronary atherosclerosis","volume":"24","author":"Sato","year":"2022","journal-title":"Curr Atheroscler Rep"},{"key":"2023123123555472100_ehad720-B39","doi-asserted-by":"crossref","first-page":"e011612","DOI":"10.1161\/CIRCINTERVENTIONS.121.011612","article-title":"Sex differences in culprit plaque characteristics among different age groups in patients with acute coronary syndromes","volume":"15","author":"Seegers","year":"2022","journal-title":"Circ Cardiovasc Interv"},{"key":"2023123123555472100_ehad720-B40","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1136\/hrt.2004.034058","article-title":"Proportion of fibrin and platelets differs in thrombi on ruptured and eroded coronary atherosclerotic plaques in humans","volume":"91","author":"Sato","year":"2005","journal-title":"Heart"},{"key":"2023123123555472100_ehad720-B41","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1160\/TH14-09-0801","article-title":"Plasma fibrin clot phenotype independently affects intracoronary thrombus ultrastructure in patients with acute myocardial infarction","volume":"113","author":"Zalewski","year":"2015","journal-title":"Thromb Haemost"},{"key":"2023123123555472100_ehad720-B42","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.jacc.2010.09.077","article-title":"Composition of coronary thrombus in acute myocardial infarction","volume":"57","author":"Silvain","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"2023123123555472100_ehad720-B43","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.resuscitation.2017.01.030","article-title":"Thrombus composition in sudden cardiac death from acute myocardial infarction","volume":"113","author":"Silvain","year":"2017","journal-title":"Resuscitation"},{"key":"2023123123555472100_ehad720-B44","doi-asserted-by":"crossref","first-page":"e004506","DOI":"10.1161\/CIRCIMAGING.116.004506","article-title":"Sex differences in nonculprit coronary plaque microstructures on frequency-domain optical coherence tomography in acute coronary syndromes and stable coronary artery disease","volume":"9","author":"Kataoka","year":"2016","journal-title":"Circ Cardiovasc Imaging"},{"key":"2023123123555472100_ehad720-B45","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s11239-019-01969-9","article-title":"Relative risk of plaque erosion among different age and sex groups in patients with acute coronary syndrome","volume":"49","author":"Kim","year":"2020","journal-title":"J Thromb Thrombolysis"},{"key":"2023123123555472100_ehad720-B46","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1067\/mhj.2001.109946","article-title":"Effect of menopause on plaque morphologic characteristics in coronary atherosclerosis","volume":"141","author":"Burke","year":"2001","journal-title":"Am Heart J"},{"key":"2023123123555472100_ehad720-B47","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1161\/ATVBAHA.120.315754","article-title":"Thrombus structural composition in cardiovascular disease","volume":"41","author":"Alkarithi","year":"2021","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2023123123555472100_ehad720-B48","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.3390\/ph15111428","article-title":"Integrating mechanisms in thrombotic peripheral arterial disease","volume":"15","author":"Nagy","year":"2022","journal-title":"Pharmaceuticals [Internet]"},{"key":"2023123123555472100_ehad720-B49","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1111\/j.1538-7836.2010.03843.x","article-title":"Disturbed blood flow induces erosive injury to smooth muscle cell-rich neointima and promotes thrombus formation in rabbit femoral arteries","volume":"8","author":"Sumi","year":"2010","journal-title":"J Thromb Haemost"},{"key":"2023123123555472100_ehad720-B50","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1093\/cvr\/cvaa251","article-title":"High spatial endothelial shear stress gradient independently predicts site of acute coronary plaque rupture and erosion","volume":"117","author":"Thondapu","year":"2021","journal-title":"Cardiovasc Res"},{"key":"2023123123555472100_ehad720-B51","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1161\/01.CIR.92.3.657","article-title":"Coronary plaque disruption","volume":"92","author":"Falk","year":"1995","journal-title":"Circulation"},{"key":"2023123123555472100_ehad720-B52","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0735-1097(99)00533-1","article-title":"Morphology of vulnerable coronary plaque: insights from follow-up of patients examined by intravascular ultrasound before an acute coronary syndrome","volume":"35","author":"Yamagishi","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"2023123123555472100_ehad720-B53","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s00330-008-1223-3","article-title":"Coronary artery plaque formation at coronary CT angiography: morphological analysis and relationship to hemodynamics","volume":"19","author":"Enrico","year":"2009","journal-title":"Eur Radiol"},{"key":"2023123123555472100_ehad720-B54","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.jacc.2007.10.030","article-title":"Localized elevation of shear stress is related to coronary plaque rupture: a 3-dimensional intravascular ultrasound study with in-vivo color mapping of shear stress distribution","volume":"51","author":"Fukumoto","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"2023123123555472100_ehad720-B55","doi-asserted-by":"crossref","first-page":"e24-6","DOI":"10.1016\/j.ijcard.2011.07.005","article-title":"Fusion of optical coherence tomography and coronary angiography\u2014in vivo assessment of shear stress in plaque rupture","volume":"155","author":"Bourantas","year":"2012","journal-title":"Int J Cardiol"},{"key":"2023123123555472100_ehad720-B56","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/S0140-6736(89)90953-7","article-title":"Influence of plaque configuration and stress distribution on fissuring of coronary atherosclerotic plaques","volume":"2","author":"Richardson","year":"1989","journal-title":"Lancet"},{"key":"2023123123555472100_ehad720-B57","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.1182\/blood.V88.9.3456.bloodjournal8893456","article-title":"High shear stress can initiate both platelet aggregation and shedding of procoagulant containing microparticles","volume":"88","author":"Miyazaki","year":"1996","journal-title":"Blood"},{"key":"2023123123555472100_ehad720-B58","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nm.1955","article-title":"A shear gradient-dependent platelet aggregation mechanism drives thrombus formation","volume":"15","author":"Nesbitt","year":"2009","journal-title":"Nat Med"},{"key":"2023123123555472100_ehad720-B59","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3233\/BIR-2011-0585","article-title":"Computational study on effect of stenosis on primary thrombus formation","volume":"48","author":"Kamada","year":"2011","journal-title":"Biorheology"},{"key":"2023123123555472100_ehad720-B60","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.mvr.2013.08.008","article-title":"Hemodynamic features and platelet aggregation in a stenosed microchannel","volume":"90","author":"Ha","year":"2013","journal-title":"Microvasc Res"},{"key":"2023123123555472100_ehad720-B61","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1002\/bit.24537","article-title":"Correlation of thrombosis growth rate to pathological wall shear rate during platelet accumulation","volume":"109","author":"Bark","year":"2012","journal-title":"Biotechnol Bioeng"},{"key":"2023123123555472100_ehad720-B62","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.1016\/j.jbiomech.2010.07.011","article-title":"Wall shear over high degree stenoses pertinent to atherothrombosis","volume":"43","author":"Bark","year":"2010","journal-title":"J Biomech"},{"key":"2023123123555472100_ehad720-B63","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.actbio.2018.04.002","article-title":"Effects of upstream shear forces on priming of platelets for downstream adhesion and activation","volume":"73","author":"Rahman","year":"2018","journal-title":"Acta Biomater"},{"key":"2023123123555472100_ehad720-B64","doi-asserted-by":"crossref","first-page":"4257","DOI":"10.1038\/ncomms5257","article-title":"Identification of platelet function defects by multi-parameter assessment of thrombus formation","volume":"5","author":"de Witt","year":"2014","journal-title":"Nat Commun"},{"key":"2023123123555472100_ehad720-B65","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/jth.13249","article-title":"Collagen-mediated hemostasis","volume":"14","author":"Manon-Jensen","year":"2016","journal-title":"J Thromb Haemost"},{"key":"2023123123555472100_ehad720-B66","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1055\/s-0043-1761463","article-title":"Pharmacological inhibition of glycoprotein VI- and integrin \u03b12\u03b21-induced thrombus formation modulated by the collagen type","volume":"123","author":"Jooss","year":"2023","journal-title":"Thromb Haemost [Internet]"},{"key":"2023123123555472100_ehad720-B67","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1111\/jth.15836","article-title":"Anti-GPVI nanobody blocks collagen- and atherosclerotic plaque-induced GPVI clustering, signaling, and thrombus formation","volume":"20","author":"Jooss","year":"2022","journal-title":"J Thromb Haemost"},{"key":"2023123123555472100_ehad720-B68","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1096\/fj.04-2748com","article-title":"Human atheromatous plaques stimulate thrombus formation by activating platelet glycoprotein VI","volume":"19","author":"Penz","year":"2005","journal-title":"FASEB J"},{"key":"2023123123555472100_ehad720-B69","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.atherosclerosis.2004.12.037","article-title":"Contribution of platelet glycoprotein VI to the thrombogenic effect of collagens in fibrous atherosclerotic lesions","volume":"181","author":"Cosemans","year":"2005","journal-title":"Atherosclerosis"},{"key":"2023123123555472100_ehad720-B70","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s00395-008-0722-3","article-title":"Platelet GPVI binds to collagenous structures in the core region of human atheromatous plaque and is critical for atheroprogression in vivo","volume":"103","author":"Schulz","year":"2008","journal-title":"Basic Res Cardiol"},{"key":"2023123123555472100_ehad720-B71","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.matbio.2018.03.003","article-title":"Role of hyaluronan in atherosclerosis: current knowledge and open questions","volume":"78\u201379","author":"Fischer","year":"2019","journal-title":"Matrix Biol"},{"key":"2023123123555472100_ehad720-B72","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1182\/blood.V84.2.390.390","article-title":"CD44 can mediate the adhesion of platelets to hyaluronan","volume":"84","author":"Koshiishi","year":"1994","journal-title":"Blood"},{"key":"2023123123555472100_ehad720-B73","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.2353\/ajpath.2009.080831","article-title":"Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines","volume":"174","author":"de la Motte","year":"2009","journal-title":"Am J Pathol"},{"key":"2023123123555472100_ehad720-B74","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1080\/14756366.2021.1900159","article-title":"Platelet hyaluronidase 2 enrichment in acute coronary syndromes: a conceivable role in monocyte-platelet aggregate formation","volume":"36","author":"Vinci","year":"2021","journal-title":"J Enzyme Inhib Med Chem"},{"key":"2023123123555472100_ehad720-B75","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1016\/j.jacc.2018.06.072","article-title":"Alterations of hyaluronan metabolism in acute coronary syndrome: implications for plaque erosion","volume":"72","author":"Pedicino","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2023123123555472100_ehad720-B76","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1096\/fj.02-0382com","article-title":"Vascular PG-M\/versican variants promote platelet adhesion at low shear rates and cooperate with collagens to induce aggregation","volume":"16","author":"Mazzucato","year":"2002","journal-title":"FASEB J"},{"key":"2023123123555472100_ehad720-B77","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1182\/blood.V100.5.1707.h81702001707_1707_1714","article-title":"The small proteoglycan decorin supports adhesion and activation of human platelets","volume":"100","author":"Guidetti","year":"2002","journal-title":"Blood"},{"key":"2023123123555472100_ehad720-B78","doi-asserted-by":"crossref","first-page":"12168","DOI":"10.3390\/ijms222212168","article-title":"The proteoglycan biglycan modulates platelet adhesion and thrombus formation in a GPVI-dependent manner","volume":"22","author":"Hoermann","year":"2021","journal-title":"Int J Mol Sci [Internet]"},{"key":"2023123123555472100_ehad720-B79","doi-asserted-by":"crossref","first-page":"e70","DOI":"10.1016\/j.thromres.2012.01.003","article-title":"Podoplanin expression in advanced atherosclerotic lesions of human aortas","volume":"129","author":"Hatakeyama","year":"2012","journal-title":"Thromb Res"},{"key":"2023123123555472100_ehad720-B80","doi-asserted-by":"crossref","first-page":"e0139357","DOI":"10.1371\/journal.pone.0139357","article-title":"Vascular smooth muscle cells stimulate platelets and facilitate thrombus formation through platelet CLEC-2: implications in atherothrombosis","volume":"10","author":"Inoue","year":"2015","journal-title":"PLoS One"},{"key":"2023123123555472100_ehad720-B81","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.thromres.2019.10.015","article-title":"Podoplanin expression on endothelial cells promotes superficial erosive injury and thrombus formation in rat carotid artery: implications for plaque erosion","volume":"183","author":"Furukoji","year":"2019","journal-title":"Thromb Res"},{"key":"2023123123555472100_ehad720-B82","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1055\/a-1896-6992","article-title":"CLEC-2 Supports platelet aggregation in mouse but not human blood at arterial shear","volume":"122","author":"Bourne","year":"2022","journal-title":"Thromb Haemost"},{"key":"2023123123555472100_ehad720-B83","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1073\/pnas.86.8.2839","article-title":"Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque","volume":"86","author":"Wilcox","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023123123555472100_ehad720-B84","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0021-9150(97)00132-9","article-title":"Localization and activity of tissue factor in human aortic atherosclerotic lesions","volume":"133","author":"Hatakeyama","year":"1997","journal-title":"Atherosclerosis"},{"key":"2023123123555472100_ehad720-B85","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/pin.12921","article-title":"Pathophysiology of atherothrombosis: mechanisms of thrombus formation on disrupted atherosclerotic plaques","volume":"70","author":"Asada","year":"2020","journal-title":"Pathol Int"},{"key":"2023123123555472100_ehad720-B86","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1253\/circj.CJ-15-0394","article-title":"Human coronary thrombus formation is associated with degree of plaque disruption and expression of tissue factor and hexokinase II","volume":"79","author":"Okuyama","year":"2015","journal-title":"Circ J"},{"key":"2023123123555472100_ehad720-B87","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1161\/ATVBAHA.114.303315","article-title":"Factor XII regulates the pathological process of thrombus formation on ruptured plaques","volume":"34","author":"Kuijpers","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2023123123555472100_ehad720-B88","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1055\/s-0040-1716539","article-title":"Pathological features of ruptured coronary plaque and thrombus interfaces: fibrin and von Willebrand factor as platelet scaffolds on rupture sites","volume":"121","author":"Yamashita","year":"2021","journal-title":"Thromb Haemost"},{"key":"2023123123555472100_ehad720-B89","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1055\/s-0040-1710012","article-title":"Glycoprotein VI is not a functional platelet receptor for fibrin formed in plasma or blood","volume":"120","author":"Zhang","year":"2020","journal-title":"Thromb Haemost"},{"key":"2023123123555472100_ehad720-B90","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.jtha.2022.09.004","article-title":"Fibrin-glycoprotein VI interaction increases platelet procoagulant activity and impacts clot structure","volume":"21","author":"Gauer","year":"2022","journal-title":"J Thromb Haemost [Internet]"},{"key":"2023123123555472100_ehad720-B91","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1073\/pnas.1209905110","article-title":"Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner","volume":"110","author":"Westein","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023123123555472100_ehad720-B92","doi-asserted-by":"crossref","first-page":"e10130","DOI":"10.1371\/journal.pone.0010130","article-title":"Stabilizing role of platelet P2Y(12) receptors in shear-dependent thrombus formation on ruptured plaques","volume":"5","author":"Nergiz-Unal","year":"2010","journal-title":"PLoS One"},{"key":"2023123123555472100_ehad720-B93","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1055\/s-0038-1649251","article-title":"ADPase activity of normal and atherosclerotic human aorta intima","volume":"37","author":"du p Heyns","year":"1977","journal-title":"Thromb Haemost"},{"key":"2023123123555472100_ehad720-B94","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1161\/01.CIR.0000155239.46511.79","article-title":"Adenovirus-mediated transfer of human placental ectonucleoside triphosphate diphosphohydrolase to vascular smooth muscle cells suppresses platelet aggregation in vitro and arterial thrombus formation in vivo","volume":"111","author":"Furukoji","year":"2005","journal-title":"Circulation"},{"key":"2023123123555472100_ehad720-B95","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1161\/ATVBAHA.122.318179","article-title":"Regulation of VWF (von Willebrand factor) in inflammatory thrombosis","volume":"42","author":"Manz","year":"2022","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2023123123555472100_ehad720-B96","doi-asserted-by":"crossref","first-page":"E5556-65","DOI":"10.1073\/pnas.1801366115","article-title":"Role of CD40 and ADAMTS13 in von Willebrand factor-mediated endothelial cell-platelet-monocyte interaction","volume":"115","author":"Popa","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023123123555472100_ehad720-B97","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1055\/s-0041-1733800","article-title":"Inverse regulation of confluence-dependent ADAMTS13 and von Willebrand factor expression in human endothelial cells","volume":"122","author":"Popa","year":"2022","journal-title":"Thromb Haemost"},{"key":"2023123123555472100_ehad720-B98","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/j.1749-6632.1999.tb07725.x","article-title":"Enhanced expression of matrix metalloproteinase-3, -12, and -13 mRNAs in the aortas of apolipoprotein E-deficient mice with advanced atherosclerosis","volume":"878","author":"Jeng","year":"1999","journal-title":"Ann N Y Acad Sci"},{"key":"2023123123555472100_ehad720-B99","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1111\/jth.14729","article-title":"Cleavage by MMP-13 renders VWF unable to bind to collagen but increases its platelet reactivity","volume":"18","author":"Howes","year":"2020","journal-title":"J Thromb Haemost"},{"key":"2023123123555472100_ehad720-B100","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/35393","article-title":"CD40 Ligand on activated platelets triggers an inflammatory reaction of endothelial cells","volume":"391","author":"Henn","year":"1998","journal-title":"Nature"},{"key":"2023123123555472100_ehad720-B101","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fcvm.2017.00040","article-title":"CD40L and its receptors in atherothrombosis-an update","volume":"4","author":"Michel","year":"2017","journal-title":"Front Cardiovasc Med"},{"key":"2023123123555472100_ehad720-B102","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.1038\/s41467-021-23909-z","article-title":"Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease","volume":"12","author":"Lacy","year":"2021","journal-title":"Nat Commun"},{"key":"2023123123555472100_ehad720-B103","doi-asserted-by":"crossref","first-page":"4317","DOI":"10.1182\/blood-2010-01-261206","article-title":"Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis","volume":"116","author":"Lievens","year":"2010","journal-title":"Blood"},{"key":"2023123123555472100_ehad720-B104","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1161\/ATVBAHA.114.305127","article-title":"Platelet CD40L modulates thrombus growth via phosphatidylinositol 3-kinase \u03b2, and not via CD40 and I\u03baB kinase \u03b1","volume":"35","author":"Kuijpers","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2023123123555472100_ehad720-B105","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1161\/01.RES.86.2.131","article-title":"The stromal cell-derived factor-1 chemokine is a potent platelet agonist highly expressed in atherosclerotic plaques","volume":"86","author":"Abi-Younes","year":"2000","journal-title":"Circ Res"},{"key":"2023123123555472100_ehad720-B106","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1093\/eurheartj\/ehn566","article-title":"Expression of stromal-cell-derived factor-1 on circulating platelets is increased in patients with acute coronary syndrome and correlates with the number of CD34 + progenitor cells","volume":"30","author":"Stellos","year":"2009","journal-title":"Eur Heart J"},{"key":"2023123123555472100_ehad720-B107","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cellsig.2014.09.021","article-title":"SDF-1\u03b1 is a novel autocrine activator of platelets operating through its receptor CXCR4","volume":"27","author":"Walsh","year":"2015","journal-title":"Cell Signal"},{"key":"2023123123555472100_ehad720-B108","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1182\/blood.2020010140","article-title":"Targeting platelet-derived CXCL12 impedes arterial thrombosis","volume":"139","author":"Leberzammer","year":"2022","journal-title":"Blood"},{"key":"2023123123555472100_ehad720-B109","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1161\/ATVBAHA.112.301162","article-title":"CXCL12 Promotes the stabilization of atherosclerotic lesions mediated by smooth muscle progenitor cells in Apoe-deficient mice","volume":"33","author":"Akhtar","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2023123123555472100_ehad720-B110","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1080\/09537104.2016.1203399","article-title":"Platelet surface expression of SDF-1 is associated with clinical outcomes in the patients with cardiovascular disease","volume":"28","author":"Rath","year":"2017","journal-title":"Platelets"},{"key":"2023123123555472100_ehad720-B111","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/jth.13925","article-title":"Oxidized low-density lipoprotein in inflammation-driven thrombosis","volume":"16","author":"Obermayer","year":"2018","journal-title":"J Thromb Haemost"},{"key":"2023123123555472100_ehad720-B112","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1038\/nm1626","article-title":"Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype","volume":"13","author":"Podrez","year":"2007","journal-title":"Nat Med"},{"key":"2023123123555472100_ehad720-B113","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1161\/CIRCRESAHA.108.172064","article-title":"A specific CD36-dependent signaling pathway is required for platelet activation by oxidized low-density lipoprotein","volume":"102","author":"Chen","year":"2008","journal-title":"Circ Res"},{"key":"2023123123555472100_ehad720-B114","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.atherosclerosis.2014.08.041","article-title":"LDL Oxidation by platelets propagates platelet activation via an oxidative stress-mediated mechanism","volume":"237","author":"Carnevale","year":"2014","journal-title":"Atherosclerosis"},{"key":"2023123123555472100_ehad720-B115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/sca.4950280101","article-title":"Cholesterol crystals rupture biological membranes and human plaques during acute cardiovascular events\u2013a novel insight into plaque rupture by scanning electron microscopy","volume":"28","author":"Abela","year":"2006","journal-title":"Scanning"},{"key":"2023123123555472100_ehad720-B116","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.amjcard.2008.12.019","article-title":"Effect of cholesterol crystals on plaques and intima in arteries of patients with acute coronary and cerebrovascular syndromes","volume":"103","author":"Abela","year":"2009","journal-title":"Am J Cardiol"},{"key":"2023123123555472100_ehad720-B117","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/0735-1097(94)90657-2","article-title":"Characterization of the relative thrombogenicity of atherosclerotic plaque components: implications for consequences of plaque rupture","volume":"23","author":"Fern\u00e1ndez-Ortiz","year":"1994","journal-title":"J Am Coll Cardiol"},{"key":"2023123123555472100_ehad720-B118","doi-asserted-by":"crossref","first-page":"e37-52","DOI":"10.1161\/CIRCRESAHA.119.315625","article-title":"Crystal clots as therapeutic target in cholesterol crystal embolism","volume":"126","author":"Shi","year":"2020","journal-title":"Circ Res"},{"key":"2023123123555472100_ehad720-B119","doi-asserted-by":"crossref","first-page":"853","DOI":"10.4049\/jimmunol.1900503","article-title":"Cholesterol crystals induce coagulation activation through complement-dependent expression of monocytic tissue factor","volume":"203","author":"Gravastrand","year":"2019","journal-title":"J Immunol"},{"key":"2023123123555472100_ehad720-B120","doi-asserted-by":"crossref","first-page":"100116","DOI":"10.1016\/j.rpth.2023.100116","article-title":"Novel mechanisms of thrombo-inflammation during infection: spotlight on neutrophil extracellular trap-mediated platelet activation","volume":"7","author":"Colicchia","year":"2023","journal-title":"Res Pract Thromb Haemost"},{"key":"2023123123555472100_ehad720-B121","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1055\/s-0039-1692983","article-title":"Platelet-neutrophil crosstalk in atherothrombosis","volume":"119","author":"Pircher","year":"2019","journal-title":"Thromb Haemost"},{"key":"2023123123555472100_ehad720-B122","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1161\/CIRCRESAHA.116.309692","article-title":"Neutrophil extracellular traps in atherosclerosis and atherothrombosis","volume":"120","author":"D\u00f6ring","year":"2017","journal-title":"Circ Res"},{"key":"2023123123555472100_ehad720-B123","article-title":"DNAse-dependent, NET-independent pathway of thrombus formation in vivo","volume":"118","author":"Carminita","year":"2021","journal-title":"Proc Natl Acad Sci U S A [Internet]"},{"key":"2023123123555472100_ehad720-B124","doi-asserted-by":"crossref","first-page":"15559","DOI":"10.1038\/ncomms15559","article-title":"Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIb\u03b1","volume":"8","author":"Wang","year":"2017","journal-title":"Nat Commun"},{"key":"2023123123555472100_ehad720-B125","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1126\/science.1256478","article-title":"Neutrophils scan for activated platelets to initiate inflammation","volume":"346","author":"Sreeramkumar","year":"2014","journal-title":"Science"},{"key":"2023123123555472100_ehad720-B126","doi-asserted-by":"crossref","first-page":"H1181","DOI":"10.1152\/ajpheart.00579.2020","article-title":"Extracellular vesicles: new players in regulating vascular barrier function","volume":"319","author":"Chatterjee","year":"2020","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2023123123555472100_ehad720-B127","doi-asserted-by":"crossref","first-page":"18061","DOI":"10.1038\/s41598-020-73005-3","article-title":"Mode of induction of platelet-derived extracellular vesicles is a critical determinant of their phenotype and function","volume":"10","author":"Ferreira","year":"2020","journal-title":"Sci Rep"},{"key":"2023123123555472100_ehad720-B128","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1093\/eurheartj\/ehab631","article-title":"Matrix metalloproteinase-2 on activated platelets triggers endothelial PAR-1 initiating atherosclerosis","volume":"43","author":"Momi","year":"2022","journal-title":"Eur Heart J"},{"key":"2023123123555472100_ehad720-B129","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1093\/cvr\/cvab046","article-title":"Vascular smooth muscle cells in atherosclerosis: time for a re-assessment","volume":"117","author":"Grootaert","year":"2021","journal-title":"Cardiovasc Res"},{"key":"2023123123555472100_ehad720-B130","doi-asserted-by":"crossref","first-page":"oeab017","DOI":"10.1093\/ehjopen\/oeab017","article-title":"Vitamin K antagonist use induces calcification and atherosclerotic plaque progression resulting in increased hypercoagulability","volume":"1","author":"van Gorp","year":"2021","journal-title":"Eur Heart J Open"},{"key":"2023123123555472100_ehad720-B131","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1093\/eurheartj\/ehs411","article-title":"Update on acute coronary syndromes: the pathologists\u2019 view","volume":"34","author":"Falk","year":"2013","journal-title":"Eur Heart J"},{"key":"2023123123555472100_ehad720-B132","doi-asserted-by":"crossref","first-page":"396","DOI":"10.21037\/cdt.2016.06.01","article-title":"Pathology of coronary atherosclerosis and thrombosis","volume":"6","author":"Otsuka","year":"2016","journal-title":"Cardiovasc Diagn Ther"},{"key":"2023123123555472100_ehad720-B133","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1056\/NEJMra2000317","article-title":"Atherosclerotic plaque healing","volume":"383","author":"Vergallo","year":"2020","journal-title":"N Engl J Med"},{"key":"2023123123555472100_ehad720-B134","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1161\/01.CIR.103.7.934","article-title":"Healed plaque ruptures and sudden coronary death: evidence that subclinical rupture has a role in plaque progression","volume":"103","author":"Burke","year":"2001","journal-title":"Circulation"},{"key":"2023123123555472100_ehad720-B135","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1136\/hrt.82.3.265","article-title":"Mechanisms of progression in native coronary artery disease: role of healed plaque disruption","volume":"82","author":"Mann","year":"1999","journal-title":"Heart"},{"key":"2023123123555472100_ehad720-B136","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ahj.2021.09.007","article-title":"In vivo evidence of atherosclerotic plaque erosion and healing in patients with acute coronary syndrome using serial optical coherence tomography imaging","volume":"243","author":"Yin","year":"2022","journal-title":"Am Heart J"},{"key":"2023123123555472100_ehad720-B137","first-page":"534","article-title":"Time, money and the housestaff officer","volume":"148","author":"Hughey","year":"1975","journal-title":"IMJ Ill Med J"},{"key":"2023123123555472100_ehad720-B138","doi-asserted-by":"crossref","first-page":"e771-8","DOI":"10.4244\/EIJ-D-18-01175","article-title":"Characteristics and significance of healed plaques in patients with acute coronary syndrome and stable angina: an in vivo OCT and IVUS study","volume":"15","author":"Wang","year":"2019","journal-title":"EuroIntervention"},{"key":"2023123123555472100_ehad720-B139","first-page":"631","article-title":"Association between non-culprit healed plaque and plaque progression in acute coronary syndrome patients: an optical coherence tomography study","volume":"18","author":"Yin","year":"2021","journal-title":"J Geriatr Cardiol"},{"key":"2023123123555472100_ehad720-B140","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1001\/jamacardio.2019.0275","article-title":"Coronary atherosclerotic phenotype and plaque healing in patients with recurrent acute coronary syndromes compared with patients with long-term clinical stability: an in vivo optical coherence tomography study","volume":"4","author":"Vergallo","year":"2019","journal-title":"JAMA Cardiol"},{"key":"2023123123555472100_ehad720-B141","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.atherosclerosis.2018.05.025","article-title":"In vivo optical coherence tomography imaging and histopathology of healed coronary plaques","volume":"275","author":"Shimokado","year":"2018","journal-title":"Atherosclerosis"},{"key":"2023123123555472100_ehad720-B142","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1016\/j.jacc.2018.10.093","article-title":"Healed culprit plaques in patients with acute coronary syndromes","volume":"73","author":"Fracassi","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2023123123555472100_ehad720-B143","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1093\/ehjci\/jez308","article-title":"Characteristics of non-culprit plaques in acute coronary syndrome patients with layered culprit plaque","volume":"21","author":"Russo","year":"2020","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2023123123555472100_ehad720-B144","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1053\/euhj.2002.3159","article-title":"Sudden unexpected death in young adults. Discrepancies between initiation of acute plaque complications and the onset of acute coronary death","volume":"23","author":"Henriques de Gouveia","year":"2002","journal-title":"Eur Heart J"},{"key":"2023123123555472100_ehad720-B145","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/j.1538-7836.2012.04620.x","article-title":"Early onset of endothelial cell proliferation in coronary thrombi of patients with an acute myocardial infarction: implications for plaque healing","volume":"10","author":"Li","year":"2012","journal-title":"J Thromb Haemost"},{"key":"2023123123555472100_ehad720-B146","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1161\/01.CIR.0000157141.00778.AC","article-title":"Plaque instability frequently occurs days or weeks before occlusive coronary thrombosis: a pathological thrombectomy study in primary percutaneous coronary intervention","volume":"111","author":"Rittersma","year":"2005","journal-title":"Circulation"},{"key":"2023123123555472100_ehad720-B147","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.carpath.2014.01.007","article-title":"Thrombus age, clinical presentation, and reperfusion grade in myocardial infarction","volume":"23","author":"Carol","year":"2014","journal-title":"Cardiovasc Pathol"},{"key":"2023123123555472100_ehad720-B148","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1161\/CIRCULATIONAHA.108.780734","article-title":"Presence of older thrombus is an independent predictor of long-term mortality in patients with ST-elevation myocardial infarction treated with thrombus aspiration during primary percutaneous coronary intervention","volume":"118","author":"Kramer","year":"2008","journal-title":"Circulation"},{"key":"2023123123555472100_ehad720-B149","doi-asserted-by":"crossref","first-page":"e0266634","DOI":"10.1371\/journal.pone.0266634","article-title":"Thrombus characteristics evaluated by acute optical coherence tomography in ST elevation myocardial infarction","volume":"17","author":"Eriksen","year":"2022","journal-title":"PLoS One"},{"key":"2023123123555472100_ehad720-B150","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.atherosclerosis.2017.12.001","article-title":"Relationship between thrombus age in aspirated coronary material and mid-term major adverse cardiac and cerebrovascular events in patients with acute myocardial infarction","volume":"268","author":"Nishihira","year":"2018","journal-title":"Atherosclerosis"},{"key":"2023123123555472100_ehad720-B151","doi-asserted-by":"crossref","first-page":"e5817","DOI":"10.1371\/journal.pone.0005817","article-title":"Histopathological features of aspirated thrombi after primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction","volume":"4","author":"Kramer","year":"2009","journal-title":"PLoS One"},{"key":"2023123123555472100_ehad720-B152","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1161\/01.ATV.11.5.1223","article-title":"Cytokines and growth factors positively and negatively regulate interstitial collagen gene expression in human vascular smooth muscle cells","volume":"11","author":"Amento","year":"1991","journal-title":"Arterioscler Thromb"},{"key":"2023123123555472100_ehad720-B153","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1084\/jem.20051772","article-title":"Platelets secrete stromal cell-derived factor 1alpha and recruit bone marrow-derived progenitor cells to arterial thrombi in vivo","volume":"203","author":"Massberg","year":"2006","journal-title":"J Exp Med"},{"key":"2023123123555472100_ehad720-B154","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1161\/01.ATV.0000215982.14003.b7","article-title":"Plasminogen activator inhibitor-1 from bone marrow-derived cells suppresses neointimal formation after vascular injury in mice","volume":"26","author":"Sch\u00e4fer","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2023123123555472100_ehad720-B155","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1161\/01.RES.0000096651.13001.B4","article-title":"Diverse contribution of bone marrow cells to neointimal hyperplasia after mechanical vascular injuries","volume":"93","author":"Tanaka","year":"2003","journal-title":"Circ Res"},{"key":"2023123123555472100_ehad720-B156","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1056\/NEJMra1607714","article-title":"Management of antithrombotic therapy after acute coronary syndromes","volume":"384","author":"Rodriguez","year":"2021","journal-title":"N Engl J Med"},{"key":"2023123123555472100_ehad720-B157","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s11239-019-01865-2","article-title":"Use of oral anticoagulant drugs is associated with carotid intraplaque hemorrhage in atherosclerosis patients: a meta-analysis","volume":"48","author":"Cao","year":"2019","journal-title":"J Thromb Thrombolysis"},{"key":"2023123123555472100_ehad720-B158","doi-asserted-by":"crossref","first-page":"706","DOI":"10.3389\/fimmu.2018.00706","article-title":"Vasa vasorum angiogenesis: key player in the initiation and progression of atherosclerosis and potential target for the treatment of cardiovascular disease","volume":"9","author":"Sedding","year":"2018","journal-title":"Front Immunol"},{"key":"2023123123555472100_ehad720-B159","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1136\/heartjnl-2020-316914","article-title":"Antithrombotic therapy for patients with chronic coronary syndromes","volume":"107","author":"Parker","year":"2021","journal-title":"Heart"},{"key":"2023123123555472100_ehad720-B160","first-page":"740","article-title":"Inflammation, fibrinogen and thrombin generation in patients with previous myocardial infarction","volume":"87","author":"R\u00e9ganon","year":"2002","journal-title":"Haematologica"},{"key":"2023123123555472100_ehad720-B161","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/rth2.12213","article-title":"Protease-activated receptor-mediated platelet aggregation in acute coronary syndrome patients on potent P2Y12 inhibitors","volume":"3","author":"Wadowski","year":"2019","journal-title":"Res Pract Thromb Haemost"},{"key":"2023123123555472100_ehad720-B162","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/09537104.2020.1763731","article-title":"Novel antiplatelet targets in the treatment of acute coronary syndromes","volume":"32","author":"Alenazy","year":"2021","journal-title":"Platelets"},{"key":"2023123123555472100_ehad720-B163","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1001\/jamacardio.2021.0475","article-title":"Efficacy and safety of revacept, a novel lesion-directed competitive antagonist to platelet glycoprotein VI, in patients undergoing elective percutaneous coronary intervention for stable ischemic heart disease: the randomized, double-blind, placebo-controlled ISAR-PLASTER phase 2 trial","volume":"6","author":"Mayer","year":"2021","journal-title":"JAMA Cardiol"},{"key":"2023123123555472100_ehad720-B164","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1111\/jth.14008","article-title":"Novel assay demonstrates that coronary artery disease patients have heightened procoagulant platelet response","volume":"16","author":"Pasalic","year":"2018","journal-title":"J Thromb Haemost"},{"key":"2023123123555472100_ehad720-B165","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1160\/TH08-03-0186","article-title":"Immature platelets in patients with acute coronary syndromes","volume":"101","author":"Grove","year":"2009","journal-title":"Thromb Haemost"},{"key":"2023123123555472100_ehad720-B166","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1055\/s-0041-1735972","article-title":"Effects of platelet agonists and priming on the formation of platelet populations","volume":"122","author":"Veninga","year":"2022","journal-title":"Thromb Haemost"}],"container-title":["European Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/45\/1\/18\/54877807\/ehad720.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/45\/1\/18\/54877807\/ehad720.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,31]],"date-time":"2023-12-31T23:56:52Z","timestamp":1704067012000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurheartj\/article\/45\/1\/18\/7368457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,6]]},"references-count":166,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,11,6]]},"published-print":{"date-parts":[[2024,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/eurheartj\/ehad720","relation":{},"ISSN":["0195-668X","1522-9645"],"issn-type":[{"value":"0195-668X","type":"print"},{"value":"1522-9645","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,1,1]]},"published":{"date-parts":[[2023,11,6]]}}}