{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:03:41Z","timestamp":1790834621846,"version":"4.1.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC81872867"],"award-info":[{"award-number":["NSFC81872867"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20211223"],"award-info":[{"award-number":["BK20211223"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Priority Academic Program Development"},{"name":"Jiangsu Higher Education Institutes"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>Macrophage-derived foam cells play a causal role during the pathogenesis of atherosclerosis. P2Y6 receptor (P2Y6R) highly expressed has been considered as a disease-causing factor in atherogenesis, but the detailed mechanism remains unknown. This study aims to explore P2Y6R in regulation of macrophage foaming, atherogenesis, and its downstream pathways. Furthermore, the present study sought to find a potent P2Y6R antagonist and investigate the feasibility of P2Y6R-targeting therapy for atherosclerosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The P2Y6R expression was examined in human atherosclerotic plaques and mouse artery. Atherosclerosis animal models were established in whole-body P2Y6R or macrophage-specific P2Y6R knockout mice to evaluate the role of P2Y6R. RNA sequencing, DNA pull-down experiments, and proteomic approaches were performed to investigate the downstream mechanisms. High-throughput Glide docking pipeline from repurposing drug library was performed to find potent P2Y6R antagonists.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The P2Y6R deficiency alleviated atherogenesis characterized by decreasing plaque formation and lipid deposition of the aorta. Mechanically, deletion of macrophage P2Y6R significantly inhibited uptake of oxidized low-density lipoprotein through decreasing scavenger receptor A expression mediated by phospholipase C\u03b2\/store-operated calcium entry pathways. More importantly, P2Y6R deficiency reduced the binding of scavenger receptor A to CALR, accompanied by dissociation of calreticulin and STIM1. Interestingly, thiamine pyrophosphate was found as a potent P2Y6R antagonist with excellent P2Y6R antagonistic activity and binding affinity, of which the pharmacodynamic effect and mechanism on atherosclerosis were verified.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Macrophage P2Y6R regulates phospholipase C\u03b2\/store-operated calcium entry\/calreticulin signalling pathway to increase scavenger receptor A protein level, thereby improving foam cell formation and atherosclerosis, indicating that the P2Y6R may be a potential therapeutic target for intervention of atherosclerotic diseases using P2Y6R antagonists including thiamine pyrophosphate.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehad796","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T02:59:37Z","timestamp":1701399577000},"page":"268-283","source":"Crossref","is-referenced-by-count":55,"title":["Macrophage P2Y6 receptor deletion attenuates atherosclerosis by limiting foam cell formation through phospholipase C\u03b2\/store-operated calcium entry\/calreticulin\/scavenger receptor A pathways"],"prefix":"10.1093","volume":"45","author":[{"given":"Yehong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, China Pharmaceutical University , Longmian Avenue 639, Nanjing 211198 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengze","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, China Pharmaceutical University , Longmian Avenue 639, Nanjing 211198 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanqiu","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Soochow University , Suzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Dai","sequence":"additional","affiliation":[{"name":"Experimental Teaching Center of Life Science, College of Life Sciences, Nanjing Agricultural University , Nanjing 210095 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, China Pharmaceutical University , Longmian Avenue 639, Nanjing 211198 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, China Pharmaceutical University , Longmian Avenue 639, Nanjing 211198 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, China Pharmaceutical University , Longmian Avenue 639, Nanjing 211198 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, China Pharmaceutical University , Longmian Avenue 639, Nanjing 211198 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinli","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, China Pharmaceutical University , Longmian Avenue 639, Nanjing 211198 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, China Pharmaceutical University , Longmian Avenue 639, Nanjing 211198 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1045-5466","authenticated-orcid":false,"given":"Qinghua","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, China Pharmaceutical University , Longmian Avenue 639, Nanjing 211198 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,11,30]]},"reference":[{"key":"2024012712264741000_ehad796-B1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1161\/CIRCRESAHA.121.319822","article-title":"Inflammation resolution: implications for atherosclerosis","volume":"130","author":"Doran","year":"2022","journal-title":"Circ Res"},{"key":"2024012712264741000_ehad796-B2","doi-asserted-by":"crossref","first-page":"eabl4024","DOI":"10.1126\/sciadv.abl4024","article-title":"Mitochondrial uncoupling protein 1 antagonizes atherosclerosis by blocking NLRP3 inflammasome-dependent interleukin-1\u03b2 production","volume":"7","author":"Gu","year":"2021","journal-title":"Sci Adv"},{"key":"2024012712264741000_ehad796-B3","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/s41586-021-03392-8","article-title":"The changing landscape of atherosclerosis","volume":"592","author":"Libby","year":"2021","journal-title":"Nature"},{"key":"2024012712264741000_ehad796-B4","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/s41569-021-00668-4","article-title":"Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?","volume":"19","author":"Engelen","year":"2022","journal-title":"Nat Rev Cardiol"},{"key":"2024012712264741000_ehad796-B5","doi-asserted-by":"crossref","first-page":"e1600224","DOI":"10.1126\/sciadv.1600224","article-title":"Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis","volume":"2","author":"Karunakaran","year":"2016","journal-title":"Sci Adv"},{"key":"2024012712264741000_ehad796-B6","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1172\/JCI122064","article-title":"Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation","volume":"129","author":"Zhong","year":"2019","journal-title":"J Clin Invest"},{"key":"2024012712264741000_ehad796-B7","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/cr.2017.8","article-title":"Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis","volume":"27","author":"Luo","year":"2017","journal-title":"Cell Res"},{"key":"2024012712264741000_ehad796-B8","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.molmed.2014.12.008","article-title":"Purinergic signaling in atherosclerosis","volume":"21","author":"Ferrari","year":"2015","journal-title":"Trends Mol Med"},{"key":"2024012712264741000_ehad796-B9","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1161\/CIRCRESAHA.116.309726","article-title":"Purinergic signaling in the cardiovascular system","volume":"120","author":"Burnstock","year":"2017","journal-title":"Circ Res"},{"key":"2024012712264741000_ehad796-B10","doi-asserted-by":"crossref","first-page":"6855","DOI":"10.3390\/ijms21186855","article-title":"P2y purinergic receptors, endothelial dysfunction, and cardiovascular diseases","volume":"21","author":"Strassheim","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2024012712264741000_ehad796-B11","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1146\/annurev-immunol-051116-052406","article-title":"Purine release, metabolism, and signaling in the inflammatory response","volume":"37","author":"Linden","year":"2019","journal-title":"Ann Rev Immunol"},{"key":"2024012712264741000_ehad796-B12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yjmcc.2020.02.004","article-title":"Alteration of purinergic signaling in diabetes: focus on vascular function","volume":"140","author":"Zhou","year":"2020","journal-title":"J Mol Cell Cardiol"},{"key":"2024012712264741000_ehad796-B13","doi-asserted-by":"crossref","first-page":"114419","DOI":"10.1016\/j.bcp.2021.114419","article-title":"The role of P2Y receptors in regulating immunity and metabolism","volume":"187","author":"Lov\u00e1szi","year":"2021","journal-title":"Biochem Pharmacol"},{"key":"2024012712264741000_ehad796-B14","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.pharmthera.2018.04.002","article-title":"Tools and drugs for uracil nucleotide-activated P2Y receptors","volume":"190","author":"Rafehi","year":"2018","journal-title":"Pharmacol Ther"},{"key":"2024012712264741000_ehad796-B15","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1161\/ATVBAHA.114.303585","article-title":"P2y6 deficiency limits vascular inflammation and atherosclerosis in mice","volume":"34","author":"Stachon","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2024012712264741000_ehad796-B16","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nri3520","article-title":"Macrophages in atherosclerosis: a dynamic balance","volume":"13","author":"Moore","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"2024012712264741000_ehad796-B17","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1093\/eurheartj\/ehaa770","article-title":"Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1): a crucial driver of atherosclerotic cardiovascular disease","volume":"42","author":"Akhmedov","year":"2021","journal-title":"Eur Heart J"},{"key":"2024012712264741000_ehad796-B18","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.3390\/ijms22031064","article-title":"Emerging role of the inflammasome and pyroptosis in hypertension","volume":"22","author":"De Miguel","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2024012712264741000_ehad796-B19","doi-asserted-by":"crossref","first-page":"a035253","DOI":"10.1101\/cshperspect.a035253","article-title":"The endoplasmic reticulum-plasma membrane junction: a hub for agonist regulation of Ca2+ entry","volume":"12","author":"Ong","year":"2020","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2024012712264741000_ehad796-B20","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev-physiol-052521-013426","article-title":"Physiological functions of CRAC channels","volume":"84","author":"Emrich","year":"2022","journal-title":"Ann Rev Physiol"},{"key":"2024012712264741000_ehad796-B21","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nmeth.1322","article-title":"Universal sample preparation method for proteome analysis","volume":"6","author":"Wi\u015bniewski","year":"2009","journal-title":"Nat Methods"},{"key":"2024012712264741000_ehad796-B22","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1038\/nprot.2016.136","article-title":"The MaxQuant computational platform for mass spectrometry-based shotgun proteomics","volume":"11","author":"Tyanova","year":"2016","journal-title":"Nat Protoc"},{"key":"2024012712264741000_ehad796-B23","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1021\/acs.jproteome.8b00702","article-title":"Cytoscape StringApp: network analysis and visualization of proteomics data","volume":"18","author":"Doncheva","year":"2019","journal-title":"J Proteome Res"},{"key":"2024012712264741000_ehad796-B24","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.ajhg.2011.11.007","article-title":"Thiamine pyrophosphokinase deficiency in encephalopathic children with defects in the pyruvate oxidation pathway","volume":"89","author":"Mayr","year":"2011","journal-title":"Am J Hum Genet"},{"key":"2024012712264741000_ehad796-B25","doi-asserted-by":"crossref","first-page":"109385","DOI":"10.1016\/j.jnutbio.2023.109385","article-title":"Availability of abundant thiamine determines efficiency of thermogenic activation in human neck area derived adipocytes","volume":"119","author":"Arianti","year":"2023","journal-title":"J Nutr Biochem"},{"key":"2024012712264741000_ehad796-B26","doi-asserted-by":"crossref","first-page":"eabc2697","DOI":"10.1126\/sciadv.abc2697","article-title":"Efficient aortic lymphatic drainage is necessary for atherosclerosis regression induced by ezetimibe","volume":"6","author":"Yeo","year":"2020","journal-title":"Sci Adv"},{"key":"2024012712264741000_ehad796-B27","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/s41577-021-00584-1","article-title":"How the immune system shapes atherosclerosis: roles of innate and adaptive immunity","volume":"22","author":"Roy","year":"2022","journal-title":"Nat Rev Immunol"},{"key":"2024012712264741000_ehad796-B28","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/s41392-021-00553-z","article-title":"From purines to purinergic signalling: molecular functions and human diseases","volume":"6","author":"Huang","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"2024012712264741000_ehad796-B29","doi-asserted-by":"crossref","first-page":"436","DOI":"10.4049\/jimmunol.1003746","article-title":"P2Y6 receptor signaling pathway mediates inflammatory responses induced by monosodium urate crystals","volume":"188","author":"Uratsuji","year":"2012","journal-title":"J Immunol"},{"key":"2024012712264741000_ehad796-B30","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.vph.2018.08.002","article-title":"Foam cell formation: a new target for fighting atherosclerosis and cardiovascular disease","volume":"112","author":"Maguire","year":"2019","journal-title":"Vascul Pharmacol"},{"key":"2024012712264741000_ehad796-B31","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.drudis.2019.12.015","article-title":"The role of P2Y6R in cardiovascular diseases and recent development of P2Y6R antagonists","volume":"25","author":"Zhou","year":"2020","journal-title":"Drug Discov Today"},{"key":"2024012712264741000_ehad796-B32","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1161\/01.ATV.0000229218.97976.43","article-title":"Scavenger receptors in atherosclerosis: beyond lipid uptake","volume":"26","author":"Moore","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2024012712264741000_ehad796-B33","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1161\/01.CIR.97.11.1079","article-title":"Expression of LDL receptor, VLDL receptor, LDL receptor-related protein, and scavenger receptor in rabbit atherosclerotic lesions: marked induction of scavenger receptor and VLDL receptor expression during lesion development","volume":"97","author":"Hiltunen","year":"1998","journal-title":"Circulation"},{"key":"2024012712264741000_ehad796-B34","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s12264-009-0120-3","article-title":"P2y6 receptor and immunoinflammation","volume":"25","author":"Liu","year":"2009","journal-title":"Neurosci Bull"},{"key":"2024012712264741000_ehad796-B35","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2010789118","article-title":"The store-operated Ca2+ entry complex comprises a small cluster of STIM1 associated with one orai1 channel","volume":"118","author":"Shen","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024012712264741000_ehad796-B36","doi-asserted-by":"crossref","first-page":"6064","DOI":"10.1172\/JCI136457","article-title":"BIN2 orchestrates platelet calcium signaling in thrombosis and thrombo-inflammation","volume":"130","author":"Volz","year":"2020","journal-title":"J Clin Invest"},{"key":"2024012712264741000_ehad796-B37","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1073\/pnas.0813346106","article-title":"A role for Orai in TRPC-mediated Ca2+ entry suggests that a TRPC:Orai complex may mediate store and receptor operated ca2 + entry","volume":"106","author":"Liao","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024012712264741000_ehad796-B38","doi-asserted-by":"crossref","first-page":"14922","DOI":"10.1074\/jbc.RA119.008484","article-title":"The steroid hormone 20-hydroxyecdysone induces phosphorylation and aggregation of stromal interacting molecule 1 for store-operated calcium entry","volume":"294","author":"Chen","year":"2019","journal-title":"J Biol Chem"},{"key":"2024012712264741000_ehad796-B39","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ceca.2018.11.005","article-title":"Store-operated calcium entry in thrombosis and thrombo-inflammation","volume":"77","author":"Mammadova-Bach","year":"2019","journal-title":"Cell Calcium"},{"key":"2024012712264741000_ehad796-B40","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1038\/s41598-017-02562-x","article-title":"Anti-proliferative effects of nucleotides on gastric cancer via a novel P2Y6\/SOCE\/Ca2+\/\u03b2-catenin pathway","volume":"7","author":"Wan","year":"2017","journal-title":"Sci Rep"},{"key":"2024012712264741000_ehad796-B41","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1161\/ATVBAHA.116.307344","article-title":"Inhibition of orai1 store-operated calcium channel prevents foam cell formation and atherosclerosis","volume":"36","author":"Liang","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2024012712264741000_ehad796-B42","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.molimm.2008.10.032","article-title":"Calreticulin from the intestinal nematode Heligmosomoides polygyrus is a Th2-skewing protein and interacts with murine scavenger receptor-A","volume":"46","author":"Rzepecka","year":"2009","journal-title":"Mol Immunol"},{"key":"2024012712264741000_ehad796-B43","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1182\/blood.2019001103","article-title":"Defective interaction of mutant calreticulin and SOCE in megakaryocytes from patients with myeloproliferative neoplasms","volume":"135","author":"Di Buduo","year":"2020","journal-title":"Blood"},{"key":"2024012712264741000_ehad796-B44","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2109144118","article-title":"HIF-1-regulated expression of calreticulin promotes breast tumorigenesis and progression through Wnt\/\u03b2-catenin pathway activation","volume":"118","author":"Liu","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024012712264741000_ehad796-B45","doi-asserted-by":"crossref","first-page":"4202","DOI":"10.1080\/15548627.2021.1907516","article-title":"WLS\/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism","volume":"17","author":"Wang","year":"2021","journal-title":"Autophagy"},{"key":"2024012712264741000_ehad796-B46","doi-asserted-by":"crossref","first-page":"e0003521","DOI":"10.1128\/MMBR.00035-21","article-title":"Endoplasmic reticulum chaperones in viral infection: therapeutic perspectives","volume":"85","author":"Kohli","year":"2021","journal-title":"Microbiol Mol Biol Rev"},{"key":"2024012712264741000_ehad796-B47","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.ijbiomac.2020.06.109","article-title":"N-glycan in the scavenger receptor cysteine-rich domain of hepsin promotes intracellular trafficking and cell surface expression","volume":"161","author":"Sun","year":"2020","journal-title":"Int J Biol Macromol"},{"key":"2024012712264741000_ehad796-B48","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12929-016-0244-5","article-title":"Identifying N-linked glycan moiety and motifs in the cysteine-rich domain critical for N-glycosylation and intracellular trafficking of SR-AI and MARCO","volume":"23","author":"Tsay","year":"2016","journal-title":"J Biomed Sci"},{"key":"2024012712264741000_ehad796-B49","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1172\/JCI129277","article-title":"Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis","volume":"129","author":"Kojima","year":"2019","journal-title":"J Clin Invest"},{"key":"2024012712264741000_ehad796-B50","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1161\/01.ATV.17.11.2359","article-title":"Calreticulin, a potential vascular regulatory protein, reduces intimal hyperplasia after arterial injury","volume":"17","author":"Dai","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2024012712264741000_ehad796-B51","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1038\/nature04740","article-title":"Structural basis for gene regulation by a thiamine pyrophosphate-sensing riboswitch","volume":"441","author":"Serganov","year":"2006","journal-title":"Nature"},{"key":"2024012712264741000_ehad796-B52","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1463-1326.2011.01384.x","article-title":"Emerging role of thiamine therapy for prevention and treatment of early-stage diabetic nephropathy","volume":"13","author":"Rabbani","year":"2011","journal-title":"Diabetes Obes Metab"},{"key":"2024012712264741000_ehad796-B53","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.1021\/acs.analchem.0c05276","article-title":"Engineering allosteric ribozymes to detect thiamine pyrophosphate in whole blood","volume":"93","author":"Du","year":"2021","journal-title":"Anal Chem"},{"key":"2024012712264741000_ehad796-B54","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1016\/j.bcp.2004.01.011","article-title":"Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors","volume":"67","author":"Mamedova","year":"2004","journal-title":"Biochem Pharmacol"},{"key":"2024012712264741000_ehad796-B55","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s11302-008-9106-2","article-title":"Development of selective agonists and antagonists of P2Y receptors","volume":"5","author":"Jacobson","year":"2009","journal-title":"Purinergic Signal"},{"key":"2024012712264741000_ehad796-B56","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1161\/CIRCRESAHA.117.311546","article-title":"Macrophage liver kinase B1 inhibits foam cell formation and atherosclerosis","volume":"121","author":"Liu","year":"2017","journal-title":"Circ Res"},{"key":"2024012712264741000_ehad796-B57","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/s41467-018-07895-3","article-title":"CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REG\u03b3","volume":"10","author":"Fan","year":"2019","journal-title":"Nat Commun"},{"key":"2024012712264741000_ehad796-B58","doi-asserted-by":"crossref","first-page":"4847","DOI":"10.1093\/eurheartj\/ehab660","article-title":"Macrophage NFATc3 prevents foam cell formation and atherosclerosis: evidence and mechanisms","volume":"42","author":"Liu","year":"2021","journal-title":"Eur Heart J"}],"container-title":["European Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/45\/4\/268\/56432857\/ehad796.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/45\/4\/268\/56432857\/ehad796.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T12:28:00Z","timestamp":1706358480000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurheartj\/article\/45\/4\/268\/7456370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,30]]},"references-count":58,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,11,30]]},"published-print":{"date-parts":[[2024,1,27]]}},"URL":"https:\/\/doi.org\/10.1093\/eurheartj\/ehad796","relation":{},"ISSN":["0195-668X","1522-9645"],"issn-type":[{"value":"0195-668X","type":"print"},{"value":"1522-9645","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,1,21]]},"published":{"date-parts":[[2023,11,30]]}}}