{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:28:28Z","timestamp":1792790908745,"version":"4.5.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Air pollutants are important contributors to cardiovascular diseases, but associations between long-term exposure to air pollutants and the risk of abdominal aortic aneurysm (AAA) are still unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was conducted using a sample of 449 463 participants from the UK Biobank. Hazard ratios and 95% confidence intervals for the risk of AAA incidence associated with long-term exposure to air pollutants were estimated using the Cox proportional hazards model with time-varying exposure measurements. Additionally, the cumulative incidence of AAA was calculated by using the Fine and Grey sub-distribution hazards regression model. Furthermore, this study investigated the combined effects and interactions between air pollutants exposure and genetic predisposition in relation to the risk of AAA onset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Long-term exposure to particulate matter with an aerodynamic diameter &amp;lt;2.5\u2005\u00b5m [PM2.5, 1.21 (1.16, 1.27)], particulate matter with an aerodynamic diameter &amp;lt;10\u2005\u00b5m [PM10, 1.21 (1.16, 1.27)], nitrogen dioxide [NO2, 1.16 (1.11, 1.22)], and nitrogen oxides [NOx, 1.10 (1.05, 1.15)] was found to be associated with an elevated risk of AAA onset. The detrimental effects of air pollutants persisted even in participants with low-level exposure. For the joint associations, participants with both high levels of air pollutants exposure and high genetic risk had a higher risk of developing AAA compared with those with low concentrations of pollutants exposure and low genetic risk. The respective risk estimates for AAA incidence were 3.18 (2.46, 4.12) for PM2.5, 3.09 (2.39, 4.00) for PM10, 2.41 (1.86, 3.13) for NO2, and 2.01 (1.55, 2.61) for NOx.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this study, long-term air pollutants exposure was associated with an increased risk of AAA incidence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehad886","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T12:59:27Z","timestamp":1703163567000},"page":"1030-1039","source":"Crossref","is-referenced-by-count":79,"title":["Air pollutants, genetic susceptibility, and abdominal aortic aneurysm risk: a prospective study"],"prefix":"10.1093","volume":"45","author":[{"given":"Yudiyang","family":"Ma","sequence":"first","affiliation":[{"name":"Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , No. 13 Hangkong Road, Wuhan 430030 , China"},{"name":"Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , No. 13 Hangkong Road, Wuhan 430030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dankang","family":"Li","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , No. 13 Hangkong Road, Wuhan 430030 , China"},{"name":"Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , No. 13 Hangkong Road, Wuhan 430030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feipeng","family":"Cui","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , No. 13 Hangkong Road, Wuhan 430030 , China"},{"name":"Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , No. 13 Hangkong Road, Wuhan 430030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianing","family":"Wang","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , No. 13 Hangkong Road, Wuhan 430030 , China"},{"name":"Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , No. 13 Hangkong Road, Wuhan 430030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linxi","family":"Tang","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , No. 13 Hangkong Road, Wuhan 430030 , China"},{"name":"Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , No. 13 Hangkong Road, Wuhan 430030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingping","family":"Yang","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , No. 13 Hangkong Road, Wuhan 430030 , China"},{"name":"Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , No. 13 Hangkong Road, Wuhan 430030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Run","family":"Liu","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , No. 13 Hangkong Road, Wuhan 430030 , China"},{"name":"Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , No. 13 Hangkong Road, Wuhan 430030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9853-6991","authenticated-orcid":false,"given":"Yaohua","family":"Tian","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , No. 13 Hangkong Road, Wuhan 430030 , China"},{"name":"Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , No. 13 Hangkong Road, Wuhan 430030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,18]]},"reference":[{"key":"2024032801034618000_ehad886-B1","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1001\/jama.2022.18638","article-title":"What is an abdominal aortic aneurysm?","volume":"328","author":"Baman","year":"2022","journal-title":"JAMA"},{"key":"2024032801034618000_ehad886-B2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41572-018-0030-7","article-title":"Abdominal aortic aneurysms","volume":"4","author":"Sakalihasan","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"2024032801034618000_ehad886-B3","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/S0140-6736(14)60109-4","article-title":"Mortality from ruptured abdominal aortic aneurysms: clinical lessons from a comparison of outcomes in England and the USA","volume":"383","author":"Karthikesalingam","year":"2014","journal-title":"Lancet"},{"issue":"Suppl 1)","key":"2024032801034618000_ehad886-B4","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.ejvs.2010.09.011","article-title":"Management of abdominal aortic aneurysms clinical practice guidelines of the European society for vascular surgery","volume":"41","author":"Moll","year":"2011","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"2024032801034618000_ehad886-B5","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/joim.13467","article-title":"Ambient air pollution and cardiovascular diseases: an umbrella review of systematic reviews and meta-analyses","volume":"291","author":"de Bont","year":"2022","journal-title":"J Intern Med"},{"key":"2024032801034618000_ehad886-B6","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.biopha.2018.04.107","article-title":"PM2.5 promotes abdominal aortic aneurysm formation in angiotensin \u2161-infused apoe\u2212\/\u2212 mice","volume":"104","author":"Jun","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"2024032801034618000_ehad886-B7","doi-asserted-by":"crossref","first-page":"e99","DOI":"10.1016\/j.jacc.2022.12.029","article-title":"Air pollution and rupture of abdominal aortic aneurysms","volume":"81","author":"Bozzani","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"2024032801034618000_ehad886-B8","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1183\/09031936.00114713","article-title":"Nitrogen dioxide and mortality: review and meta-analysis of long-term studies","volume":"44","author":"Faustini","year":"2014","journal-title":"Eur Respir J"},{"key":"2024032801034618000_ehad886-B9","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/bjs.1800641102","article-title":"Familial abdominal aortic aneurysms","volume":"64","author":"Clifton","year":"2005","journal-title":"Br J Surg"},{"key":"2024032801034618000_ehad886-B10","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1001\/jama.1986.03380140104031","article-title":"Familial tendency for abdominal aortic aneurysms","volume":"256","author":"Johansen","year":"1986","journal-title":"JAMA"},{"key":"2024032801034618000_ehad886-B11","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/0002-9610(84)90020-5","article-title":"Fifty families with abdominal aortic aneurysms in two or more first-order relatives","volume":"147","author":"Tilson","year":"1984","journal-title":"Am J Surg"},{"key":"2024032801034618000_ehad886-B12","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1161\/CIRCRESAHA.116.308765","article-title":"Meta-analysis of genome-wide association studies for abdominal aortic aneurysm identifies four new disease-specific risk loci","volume":"120","author":"Jones","year":"2017","journal-title":"Circ Res"},{"key":"2024032801034618000_ehad886-B13","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1161\/CIRCULATIONAHA.120.047544","article-title":"Genetic architecture of abdominal aortic aneurysm in the million veteran program","volume":"142","author":"Klarin","year":"2020","journal-title":"Circulation"},{"key":"2024032801034618000_ehad886-B14","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s00439-019-02004-w","article-title":"A review of gene-by-air pollution interactions for cardiovascular disease, risk factors, and biomarkers","volume":"138","author":"Ward-Caviness","year":"2019","journal-title":"Hum Genet"},{"key":"2024032801034618000_ehad886-B15","doi-asserted-by":"crossref","first-page":"e1001779","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Med"},{"key":"2024032801034618000_ehad886-B16","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41586-023-05874-3","article-title":"Lung adenocarcinoma promotion by air pollutants","volume":"616","author":"Hill","year":"2023","journal-title":"Nature"},{"key":"2024032801034618000_ehad886-B17","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.envint.2017.07.018","article-title":"Maternal exposure to ambient air pollution and fetal growth in North-East Scotland: a population-based study using routine ultrasound scans","volume":"107","author":"Clemens","year":"2017","journal-title":"Environ Int"},{"key":"2024032801034618000_ehad886-B18","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1093\/eurheartj\/ehs480","article-title":"Long-term exposure to air pollution is associated with survival following acute coronary syndrome","volume":"34","author":"Tonne","year":"2013","journal-title":"Eur Heart J"},{"key":"2024032801034618000_ehad886-B19","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1186\/s12916-022-02573-0","article-title":"Ambient air pollution associated with incidence and dynamic progression of type 2 diabetes: a trajectory analysis of a population-based cohort","volume":"20","author":"Wu","year":"2022","journal-title":"BMC Med"},{"key":"2024032801034618000_ehad886-B20","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41586-018-0579-z","article-title":"The UK Biobank resource with deep phenotyping and genomic data","volume":"562","author":"Bycroft","year":"2018","journal-title":"Nature"},{"key":"2024032801034618000_ehad886-B21","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1161\/CIRCULATIONAHA.120.053022","article-title":"Derivation and validation of a 10-year risk score for symptomatic abdominal aortic aneurysm: cohort study of nearly 500 000 individuals","volume":"144","author":"Welsh","year":"2021","journal-title":"Circulation"},{"key":"2024032801034618000_ehad886-B22","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/eurheartj\/ehz388","article-title":"Body mass index and body composition in relation to 14 cardiovascular conditions in UK Biobank: a Mendelian randomization study","volume":"41","author":"Larsson","year":"2020","journal-title":"Eur Heart J"},{"key":"2024032801034618000_ehad886-B23","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1093\/eurheartj\/ehaa193","article-title":"Genetic predisposition to smoking in relation to 14 cardiovascular diseases","volume":"41","author":"Larsson","year":"2020","journal-title":"Eur Heart J"},{"key":"2024032801034618000_ehad886-B24","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1093\/eurheartj\/ehaa1031","article-title":"Joint exposure to various ambient air pollutants and incident heart failure: a prospective analysis in UK Biobank","volume":"42","author":"Wang","year":"2021","journal-title":"Eur Heart J"},{"key":"2024032801034618000_ehad886-B25","doi-asserted-by":"crossref","first-page":"e323","DOI":"10.1016\/S2468-2667(18)30091-4","article-title":"Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493\u2008737 UK Biobank participants","volume":"3","author":"Hanlon","year":"2018","journal-title":"Lancet Public Health"},{"key":"2024032801034618000_ehad886-B26","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"key":"2024032801034618000_ehad886-B27","doi-asserted-by":"crossref","first-page":"k4168","DOI":"10.1136\/bmj.k4168","article-title":"Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: cohort study of 306 473 UK Biobank participants","volume":"363","author":"Rutten-Jacobs","year":"2018","journal-title":"BMJ"},{"key":"2024032801034618000_ehad886-B28","doi-asserted-by":"crossref","first-page":"l2408","DOI":"10.1136\/bmj.l2408","article-title":"Sugary drink consumption and risk of cancer: results from NutriNet-Sant\u00e9 prospective cohort","volume":"366","author":"Chazelas","year":"2019","journal-title":"BMJ"},{"key":"2024032801034618000_ehad886-B29","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/00001648-199605000-00012","article-title":"Confidence intervals for measures of interaction","volume":"7","author":"Assmann","year":"1996","journal-title":"Epidemiology"},{"key":"2024032801034618000_ehad886-B30","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1161\/ATVBAHA.110.203588","article-title":"Atherosclerosis in abdominal aortic aneurysms: a causal event or a process running in parallel? The Troms\u00f8 study","volume":"30","author":"Johnsen","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2024032801034618000_ehad886-B31","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1161\/ATVBAHA.120.315219","article-title":"Ambient air pollution and atherosclerosis: insights into dose, time, and mechanisms","volume":"41","author":"Bevan","year":"2021","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2024032801034618000_ehad886-B32","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1161\/CIRCRESAHA.116.309279","article-title":"Exposure to fine particulate air pollution is associated with endothelial injury and systemic inflammation","volume":"119","author":"Pope","year":"2016","journal-title":"Circ Res"},{"key":"2024032801034618000_ehad886-B33","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1161\/CIRCRESAHA.110.237560","article-title":"Chronic fine particulate matter exposure induces systemic vascular dysfunction via NADPH oxidase and TLR4 pathways","volume":"108","author":"Kampfrath","year":"2011","journal-title":"Circ Res"},{"key":"2024032801034618000_ehad886-B34","doi-asserted-by":"crossref","first-page":"e760","DOI":"10.1016\/S2542-5196(21)00287-4","article-title":"New WHO global air quality guidelines: more pressure on nations to reduce air pollution levels","volume":"5","author":"Carvalho","year":"2021","journal-title":"Lancet Planet Health"},{"key":"2024032801034618000_ehad886-B35","doi-asserted-by":"crossref","first-page":"e620","DOI":"10.1016\/S2542-5196(21)00195-9","article-title":"Long-term exposure to low-level ambient air pollution and incidence of stroke and coronary heart disease: a pooled analysis of six European cohorts within the ELAPSE project","volume":"5","author":"Wolf","year":"2021","journal-title":"Lancet Planet Health"},{"key":"2024032801034618000_ehad886-B36","doi-asserted-by":"crossref","first-page":"104879","DOI":"10.1016\/j.envint.2019.05.073","article-title":"Long-term exposure to PM(2.5) and ozone and hospital admissions of Medicare participants in the Southeast USA","volume":"130","author":"Yazdi M","year":"2019","journal-title":"Environ Int"},{"key":"2024032801034618000_ehad886-B37","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.atherosclerosis.2021.05.001","article-title":"Systematic review of genome-wide association studies of abdominal aortic aneurysm","volume":"327","author":"Singh","year":"2021","journal-title":"Atherosclerosis"},{"key":"2024032801034618000_ehad886-B38","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1146\/annurev-med-042220-011549","article-title":"Cardiovascular effects of particulate air pollution","volume":"73","author":"Bhatnagar","year":"2022","journal-title":"Annu Rev Med"},{"key":"2024032801034618000_ehad886-B39","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1161\/CIRCRESAHA.118.313187","article-title":"Cellular mechanisms of aortic aneurysm formation","volume":"124","author":"Quintana","year":"2019","journal-title":"Circ Res"},{"key":"2024032801034618000_ehad886-B40","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s11883-021-00974-9","article-title":"Gene-environment interactions for cardiovascular disease","volume":"23","author":"Hartiala","year":"2021","journal-title":"Curr Atheroscler Rep"}],"container-title":["European Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/45\/12\/1030\/57105004\/ehad886.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/45\/12\/1030\/57105004\/ehad886.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T21:04:05Z","timestamp":1711573445000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurheartj\/article\/45\/12\/1030\/7577458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,18]]},"references-count":40,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,1,18]]},"published-print":{"date-parts":[[2024,3,27]]}},"URL":"https:\/\/doi.org\/10.1093\/eurheartj\/ehad886","relation":{},"ISSN":["0195-668X","1522-9645"],"issn-type":[{"value":"0195-668X","type":"print"},{"value":"1522-9645","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,3,21]]},"published":{"date-parts":[[2024,1,18]]}}}