{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T05:58:14Z","timestamp":1794031094033,"version":"4.8.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"14","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic, Inc","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Prior reports have demonstrated a favourable safety and efficacy profile of the Micra leadless pacemaker over mid-term follow-up; however, long-term outcomes in real-world clinical practice remain unknown. Updated performance of the Micra VR leadless pacemaker through five years from the worldwide post-approval registry (PAR) was assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All Micra PAR patients undergoing implant attempts were included. Endpoints included system- or procedure-related major complications and system revision rate for any cause through 60 months post-implant. Rates were compared through 36 months post-implant to a reference dataset of 2667 transvenous pacemaker patients using Fine\u2013Gray competing risk models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>1809 patients were enrolled between July 2015 and March 2018 and underwent implant attempts from 179 centres in 23 countries with a median follow-up period of 51.1 months (IQR: 21.6\u201364.2). The major complication rate at 60 months was 4.5% [95% confidence interval (CI): 3.6%\u20135.5%] and was 4.1% at 36 months, which was significantly lower than the 8.5% rate observed for transvenous systems (HR: .47, 95% CI: .36\u2013.61; P &amp;lt; .001). The all-cause system revision rate at 60 months was 4.9% (95% CI: 3.9%\u20136.1%). System revisions among Micra patients were mostly for device upgrades (41.2%) or elevated thresholds (30.6%). There were no Micra removals due to infection noted over the duration of follow-up. At 36 months, the system revision rate was significantly lower with Micra vs. transvenous systems (3.2% vs. 6.6%, P &amp;lt; .001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Long-term outcomes with the Micra leadless pacemaker continue to demonstrate low rates of major complications and system revisions and an extremely low incidence of infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehae101","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T17:00:59Z","timestamp":1707498059000},"page":"1241-1251","source":"Crossref","is-referenced-by-count":130,"title":["Leadless pacemakers at 5-year follow-up: the Micra transcatheter pacing system post-approval registry"],"prefix":"10.1093","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4978-7177","authenticated-orcid":false,"given":"Mikhael F","family":"El-Chami","sequence":"first","affiliation":[{"name":"Division of Cardiology, Section of Electrophysiology, Emory University , Atlanta , Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2173-1035","authenticated-orcid":false,"given":"Christophe","family":"Garweg","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, Universitaire Ziekenhuizen Leuven , Leuven , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Clementy","sequence":"additional","affiliation":[{"name":"Department of Cardiologic Medicine, Centre Hospitalier Regional Universitaire de Tours\u2014Hopital Trousseau , Tours , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal","family":"Al-Samadi","sequence":"additional","affiliation":[{"name":"Department of Medicine, King Salman Heart Center\u2014King Fahad Medical City , Riyadh , Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saverio","family":"Iacopino","sequence":"additional","affiliation":[{"name":"Department of Clinical Electrophysiology & Cardiac Pacing, Centro Cardiologico Monzino, IRCCS, Department of Biomedical, Surgical, and Dental Sciences, University of Milan , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Luis","family":"Martinez-Sande","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Cardiology Service, University Clinical Hospital of Santiago de Compostela, CIBER-CV, IDIS , Santiago de Compostela , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Hospital Southampton NHS Foundation Trust , Southampton , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Tondo","sequence":"additional","affiliation":[{"name":"Monzino Cardiac Center, IRCCS, Department of Clinical Sciences and Community, University of Milan , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7157-7948","authenticated-orcid":false,"given":"Jens Brock","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital , Odense , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Vinolas-Prat","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Hospital de la Santa Creu I Sant Pau , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5897-9464","authenticated-orcid":false,"given":"Yong-Mei","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Grubman","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Yale University School of Medicine , New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Bordachar","sequence":"additional","affiliation":[{"name":"Cardio-Thoracic Unit, Bordeaux University Hospital , Pessac-Bordeaux , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3201-7993","authenticated-orcid":false,"given":"Kurt","family":"Stromberg","sequence":"additional","affiliation":[{"name":"Medtronic, Inc. , Mounds View, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dedra H","family":"Fagan","sequence":"additional","affiliation":[{"name":"Medtronic, Inc. , Mounds View, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan P","family":"Piccini","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Duke Clinical Research Institute, Duke University Medical Center , Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,1]]},"reference":[{"key":"2024040700005775400_ehae101-B1","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1093\/europace\/euac066","article-title":"Practical considerations, indications, and future perspectives for leadless and extravascular cardiac implantable electronic devices: a position paper by 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