{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:54:28Z","timestamp":1791402868952,"version":"4.3.3"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"19","license":[{"start":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T00:00:00Z","timestamp":1714089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Aspirin has been known for a long time and currently stays as a cornerstone of antithrombotic therapy in cardiovascular disease. In patients with either acute or chronic coronary syndromes undergoing percutaneous coronary intervention aspirin is mandatory in a dual antiplatelet therapy regimen for prevention of stent thrombosis and\/or new ischaemic events. Aspirin is also currently a first-option antithrombotic therapy after an aortic prosthetic valve replacement and is occasionally required in addition to oral anticoagulants after implantation of a mechanical valve. Presumed or demonstrated aspirin hypersensitivity is a main clinical problem, limiting the use of a life-saving medication. In the general population, aspirin hypersensitivity has a prevalence of 0.6%\u20132.5% and has a plethora of clinical presentations, ranging from aspirin-exacerbated respiratory disease to anaphylaxis. Although infrequent, when encountered in clinical practice aspirin hypersensitivity poses for cardiologists a clinical dilemma, which should never be trivialized, avoiding\u2014as much as possible\u2014omission of the drug. We here review the epidemiology of aspirin hypersensitivity, provide an outline of pathophysiological mechanisms and clinical presentations, and review management options, starting from a characterization of true aspirin allergy\u2014in contrast to intolerance\u2014to suggestion of desensitization protocols.<\/jats:p>","DOI":"10.1093\/eurheartj\/ehae128","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T08:47:46Z","timestamp":1714121266000},"page":"1716-1726","source":"Crossref","is-referenced-by-count":20,"title":["Aspirin hypersensitivity: a practical guide for cardiologists"],"prefix":"10.1093","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5717-4435","authenticated-orcid":false,"given":"Silvia","family":"Grimaldi","sequence":"first","affiliation":[{"name":"Postgraduate School of Cardiology, University of Pisa and Cardiovascular Division, Pisa University Hospital , Via Paradisa 2, 56124 Pisa , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6433-4964","authenticated-orcid":false,"given":"Paola","family":"Migliorini","sequence":"additional","affiliation":[{"name":"Postgraduate School of Clinical Immunology, University of Pisa , Pisa , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7293-7933","authenticated-orcid":false,"given":"Ilaria","family":"Puxeddu","sequence":"additional","affiliation":[{"name":"Postgraduate School of Clinical Immunology, University of Pisa , Pisa , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7298-2037","authenticated-orcid":false,"given":"Roberta","family":"Rossini","sequence":"additional","affiliation":[{"name":"Cardiology Division, S. Croce e Carle Hospital , Cuneo , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1637-574X","authenticated-orcid":false,"given":"Raffaele","family":"De Caterina","sequence":"additional","affiliation":[{"name":"Postgraduate School of Cardiology, University of Pisa and Cardiovascular Division, Pisa University Hospital , Via Paradisa 2, 56124 Pisa , Italy"},{"name":"Fondazione VillaSerena per la Ricerca, Viale L. Petruzzi 42, 65013 Citt\u00e0 S. Angelo , Pescara , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,26]]},"reference":[{"key":"2024080217312884100_ehae128-B1","first-page":"585","volume-title":"Allergens and Allergen Immunotherapy","author":"Solensky","year":"2004","edition":"3rd ed"},{"key":"2024080217312884100_ehae128-B2","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1001\/jama.292.24.3017","article-title":"Aspirin sensitivity: implications for patients with coronary artery disease","volume":"292","author":"Gollapudi","year":"2004","journal-title":"JAMA"},{"key":"2024080217312884100_ehae128-B3","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S1081-1206(10)62221-1","article-title":"Classification of allergic and pseudoallergic reactions to drugs that inhibit cyclooxygenase enzymes","volume":"87","author":"Stevenson","year":"2001","journal-title":"Ann Allergy Asthma 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