{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T12:32:45Z","timestamp":1793968365036,"version":"4.8.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"14","license":[{"start":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T00:00:00Z","timestamp":1709683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["PZ00P3_180055"],"award-info":[{"award-number":["PZ00P3_180055"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Available data on continuous rhythm monitoring by implantable loop recorders (ILRs) in patients with Brugada syndrome (BrS) are scarce. The aim of this multi-centre study was to evaluate the diagnostic yield and clinical implication of a continuous rhythm monitoring strategy by ILRs in a large cohort of BrS patients and to assess the precise arrhythmic cause of syncopal episodes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 370 patients with BrS and ILRs (mean age 43.5 \u00b1 15.9, 33.8% female, 74.1% symptomatic) from 18 international centers were included. Patients were followed with continuous rhythm monitoring for a median follow-up of 3 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During follow-up, an arrhythmic event was recorded in 30.7% of symptomatic patients [18.6% atrial arrhythmias (AAs), 10.2% bradyarrhythmias (BAs), and 7.3% ventricular arrhythmias (VAs)]. In patients with recurrent syncope, the aetiology was arrhythmic in 22.4% (59.3% BAs, 25.0% VAs, and 15.6% AAs). The ILR led to drug therapy initiation in 11.4%, ablation procedure in 10.9%, implantation of a pacemaker in 2.5%, and a cardioverter-defibrillator in 8%. At multivariate analysis, the presence of symptoms [hazard ratio (HR) 2.5, P = .001] and age &amp;gt;50 years (HR 1.7, P = .016) were independent predictors of arrhythmic events, while inducibility of ventricular fibrillation at the electrophysiological study (HR 9.0, P &amp;lt; .001) was a predictor of VAs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ILR detects arrhythmic events in nearly 30% of symptomatic BrS patients, leading to appropriate therapy in 70% of them. The most commonly detected arrhythmias are AAs and BAs, while VAs are detected only in 7% of cases. Symptom status can be used to guide ILR implantation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehae133","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T16:41:13Z","timestamp":1708965673000},"page":"1255-1265","source":"Crossref","is-referenced-by-count":40,"title":["Implantable loop recorders in patients with Brugada syndrome:\n                    <i>the BruLoop study<\/i>"],"prefix":"10.1093","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9864-1938","authenticated-orcid":false,"given":"Marco","family":"Bergonti","sequence":"first","affiliation":[{"name":"Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale , Via Tesserete 48, CH-6900 Lugano , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4647-8694","authenticated-orcid":false,"given":"Frederic","family":"Sacher","sequence":"additional","affiliation":[{"name":"H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, CHU Bordeaux, L\u2019Institut de Rythmologie et mod\u00e9lisation Cardiaque (LIRYC), Universit\u00e9 Bordeaux , Bordeaux , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0424-6393","authenticated-orcid":false,"given":"Elena","family":"Arbelo","sequence":"additional","affiliation":[{"name":"Arrhythmia Section, Cardiology Department, Hospital Clinic, Universitat de Barcelona , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia","family":"Crotti","sequence":"additional","affiliation":[{"name":"Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Istituto Auxologico Italiano, IRCCS , Milan , Italy"},{"name":"Departement of Medicine and Surgery, University Milano Bicocca , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4295-6679","authenticated-orcid":false,"given":"Avi","family":"Sabbag","sequence":"additional","affiliation":[{"name":"The Davidai Center for Rhythm Disturbances and Pacing, Chaim Sheba Medical Center, Tel Hashomer and the faculty of medicine, Tel-Aviv University , Tel-Aviv , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Casella","sequence":"additional","affiliation":[{"name":"Cardiology and Arrhythmology Clinic, University Hospital \u2018Ospedali Riuniti\u2019 , Ancona , Italy"},{"name":"Department of Clinical, Special and Dental Sciences, Marche Polytechnic University , Ancona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Saenen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Antwerp , Edegem , 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Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel\u2014Vrije Universiteit Brussel, European Reference Networks Guard-Heart , Brussels , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1924-6548","authenticated-orcid":false,"given":"Paolo","family":"Compagnucci","sequence":"additional","affiliation":[{"name":"Cardiology and Arrhythmology Clinic, University Hospital \u2018Ospedali Riuniti\u2019 , Ancona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Russo","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Department of Translational Medical Sciences, University of Campania \u2018Luigi Vanvitelli\u2019, Monaldi Hospital , Naples , 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