{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:00:23Z","timestamp":1791270023830,"version":"4.1.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"21","license":[{"start":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T00:00:00Z","timestamp":1711756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Edwards Lifesciences and performed under the sponsorship of IPPMed"},{"name":"Institute for Pharmacology and Preventive Medicine GmbH"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>There is significant potential to streamline the clinical pathway for patients undergoing transcatheter aortic valve implantation (TAVI). The purpose of this study was to evaluate the effect of implementing BENCHMARK best practices on the efficiency and safety of TAVI in 28 sites in 7 European countries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a study of patients with severe symptomatic aortic stenosis (AS) undergoing TAVI with balloon-expandable valves before and after implementation of BENCHMARK best practices. Principal objectives were to reduce hospital length of stay (LoS) and duration of intensive care stay. Secondary objective was to document patient safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between January 2020 and March 2023, 897 patients were documented prior to and 1491 patients after the implementation of BENCHMARK practices. Patient characteristics were consistent with a known older TAVI population and only minor differences. Mean LoS was reduced from 7.7 \u00b1 7.0 to 5.8 \u00b1 5.6 days (median 6 vs. 4 days; P &amp;lt; .001). Duration of intensive care was reduced from 1.8 to 1.3 days (median 1.1 vs. 0.9 days; P &amp;lt; .001). Adoption of peri-procedure best practices led to increased use of local anaesthesia (96.1% vs. 84.3%; P &amp;lt; .001) and decreased procedure (median 47 vs. 60\u2005min; P &amp;lt; .001) and intervention times (85 vs. 95\u2005min; P &amp;lt; .001). Thirty-day patient safety did not appear to be compromised with no differences in all-cause mortality (0.6% in both groups combined), stroke\/transient ischaemic attack (1.4%), life-threatening bleeding (1.3%), stage 2\/3 acute kidney injury (0.7%), and valve-related readmission (1.2%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Broad implementation of BENCHMARK practices contributes to improving efficiency of TAVI pathway reducing LoS and costs without compromising patient safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehae147","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T09:43:43Z","timestamp":1709113423000},"page":"1904-1916","source":"Crossref","is-referenced-by-count":44,"title":["A streamlined pathway for transcatheter aortic valve implantation: the BENCHMARK study"],"prefix":"10.1093","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7561-075X","authenticated-orcid":false,"given":"Derk","family":"Frank","sequence":"first","affiliation":[{"name":"Department of Internal Medicine III (Cardiology, Angiology and Intensive Care Medicine), University Clinical Centre Schleswig-Holstein (UKSH) , Arnold-Heller Strasse 3, Haus K3, Kiel 24105 , Germany"},{"name":"Department of Internal Medicine III (Cardiology, Angiology and Intensive Care Medicine), German Centre for Cardiovascular Research, partner site Hamburg\/Kiel\/L\u00fcbeck, Arnold-Heller Strasse 3 , Haus K3, Kiel 24105 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8171-7959","authenticated-orcid":false,"given":"Eric","family":"Durand","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Univ Rouen Normandie, Inserm U1096, CHU Rouen , Rouen , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0181-559X","authenticated-orcid":false,"given":"Sandra","family":"Lauck","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Innovation, University of British Columbia , Vancouver, BC , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1871-2869","authenticated-orcid":false,"given":"Douglas F","family":"Muir","sequence":"additional","affiliation":[{"name":"Cardiology Department, James Cook University Hospital , Middlesbrough , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Spence","sequence":"additional","affiliation":[{"name":"Cardiology Department, Mater Private Network , Dublin , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariuca","family":"Vasa-Nicotera","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Sindelfingen-B\u00f6blingen , Sindelfingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Wood","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Innovation, University of British Columbia , Vancouver, BC , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9969-2649","authenticated-orcid":false,"given":"Francesco","family":"Saia","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Bologna, Policlinico S. 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