{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T21:32:56Z","timestamp":1785792776496,"version":"3.56.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"17","license":[{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CFRPG3M0031"],"award-info":[{"award-number":["CFRPG3M0031"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MoST-110-2410-H-182A-002"],"award-info":[{"award-number":["MoST-110-2410-H-182A-002"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>Studies on the impact of syphilis on the cardiovascular system in large populations are limited. This study investigated the effects of syphilis on cardiovascular outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Medical records from 2010 to 2015 were retrieved from the Taiwan National Health Insurance Research Database, linked to the Notifiable Infectious Diseases database from the Taiwan Centers for Disease Control. Patients with syphilis were identified, excluding those with missing information, under 20 years of age, or with a history of human immunodeficiency virus infection, acute myocardial infarction, heart failure, aortic regurgitation, replacement of the aortic valve, aneurysm and\/or dissection of the aorta, atrial fibrillation, ischaemic stroke, haemorrhagic stroke, and venous thromboembolism. Primary outcomes included new-onset acute myocardial infarction, heart failure, aortic regurgitation, aneurysm and dissection of the aorta, atrial fibrillation, ischaemic stroke, haemorrhagic stroke, venous thromboembolism, cardiovascular death, and all-cause mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 28 796 patients with syphilis were identified from 2010 to 2015. After exclusions and frequency matching, 20 601 syphilis patients and 20 601 non-syphilis patients were analysed. The relative rate (RR) was utilized in the analysis, as the competing risk of death was not considered. Compared with patients without syphilis, patients with syphilis had increased risks of acute myocardial infarction (RR 38%, 95% confidence interval [CI] 1.19\u20131.60, P &amp;lt; .001), heart failure (RR 88%, 95% CI 1.64\u20132.14, P &amp;lt; .001), aortic regurgitation (RR 81%, 95% CI 1.18\u20132.75, P = .006), atrial fibrillation (RR 45%, 95% CI 1.20\u20131.76, P &amp;lt; .001), ischaemic stroke (RR 68%, 95% CI 1.52\u20131.87, P &amp;lt; .001), haemorrhagic stroke (RR 114%, 95% CI 1.74\u20132.64, P &amp;lt; .001), venous thromboembolism (RR 67%, 95% CI 1.23\u20132.26, P = .001), cardiovascular death (RR 155%, 95% CI 2.11\u20133.08, P &amp;lt; .001), and all-cause death (RR 196%, 95% CI 2.74\u20133.19, P &amp;lt; .001) but not for aneurysm and dissection of the aorta.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study demonstrates that patients with syphilis have a higher risk of cardiovascular events and all-cause mortality compared with those without syphilis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehae183","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T18:05:18Z","timestamp":1712167518000},"page":"1512-1520","source":"Crossref","is-referenced-by-count":18,"title":["Syphilis and cardiovascular risk: a Taiwanese registry"],"prefix":"10.1093","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9918-4369","authenticated-orcid":false,"given":"Victor Chien-Chia","family":"Wu","sequence":"first","affiliation":[{"name":"Division of Cardiology, Chang Gung Memorial Hospital, Linkou Medical Center , No. 5, Fuxing Street, Guishan District, Taoyuan City 33305 , Taiwan"},{"name":"College of Medicine, Chang Gung University , No. 259, Wenhua 1st Road, Guishan District, Taoyuan City 33302 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jih-Kai","family":"Yeh","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Chang Gung Memorial Hospital, Linkou Medical Center , No. 5, Fuxing Street, Guishan District, Taoyuan City 33305 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1674-1295","authenticated-orcid":false,"given":"Shao-Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Chang Gung Memorial Hospital, Linkou Medical Center , No. 5, Fuxing Street, Guishan District, Taoyuan City 33305 , Taiwan"},{"name":"Center for Big Data Analytics and Statistics, Chang Gung Memorial Hospital, Linkou Medical Center , No. 5, Fuxing Street, Guishan District, Taoyuan City 33305 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Ling","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for Big Data Analytics and Statistics, Chang Gung Memorial Hospital, Linkou Medical Center , No. 5, Fuxing Street, Guishan District, Taoyuan City 33305 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Sheng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Chang Gung Memorial Hospital , No. 6, Sec. West, Jiapu Road, Puzi City, Chiayi County 61363 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wu","sequence":"additional","affiliation":[{"name":"Divison of Cardiovascular Medicine, Arrhythmia Services Section, Rhode Island Hospital, Warren Alpert School of Medicine, Brown University , Providence, RI 02903 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1338-0140","authenticated-orcid":false,"given":"Kai-Che","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kaohsiung Veterans General Hospital , No. 386, Dazhong 1st Road, Zuoying District, Kaohsiung City 813414 , Taiwan"},{"name":"College of Medicine, National Yang Ming Chiao Tung University , No. 155, Section 2, Li-Nong Street, Beitou District, Taipei 112304 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0361-6348","authenticated-orcid":false,"given":"Pao-Hsien","family":"Chu","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Chang Gung Memorial Hospital, Linkou Medical Center , No. 5, Fuxing Street, Guishan District, Taoyuan City 33305 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0462-2344","authenticated-orcid":false,"given":"Shang-Hung","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Chang Gung Memorial Hospital, Linkou Medical Center , No. 5, Fuxing Street, Guishan District, Taoyuan City 33305 , Taiwan"},{"name":"Center for Big Data Analytics and Statistics, Chang Gung Memorial Hospital, Linkou Medical Center , No. 5, Fuxing Street, Guishan District, Taoyuan City 33305 , Taiwan"},{"name":"Graduate Institute of Nursing, Chang Gung University of Science and Technology , No. 261, Wenhua 1st Road, Guishan District, Taoyuan City 33303 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3224-7238","authenticated-orcid":false,"given":"Yu-Tung","family":"Huang","sequence":"additional","affiliation":[{"name":"Center for Big Data Analytics and Statistics, Chang Gung Memorial Hospital, Linkou Medical Center , No. 5, Fuxing Street, Guishan District, Taoyuan City 33305 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"key":"2024050717420691000_ehae183-B1","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/B978-0-323-40181-4.00182-1","volume-title":"Principles and Practice of Pediatric Infectious Diseases","author":"Rawstron","year":"2018","edition":"5th Ed."},{"key":"2024050717420691000_ehae183-B2","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.amjcard.2009.07.031","article-title":"Natural history of syphilitic aortitis","volume":"104","author":"Roberts","year":"2009","journal-title":"Am J Cardiol"},{"key":"2024050717420691000_ehae183-B3","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1056\/NEJMra1906228","article-title":"Neurosyphilis","volume":"381","author":"Ropper","year":"2019","journal-title":"N Engl J Med"},{"key":"2024050717420691000_ehae183-B4","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1001\/jamadermatol.2013.9537","article-title":"Syphilitic aortitis in secondary syphilis","volume":"150","author":"Dietrich","year":"2014","journal-title":"JAMA Dermatol"},{"key":"2024050717420691000_ehae183-B5","doi-asserted-by":"crossref","first-page":"e24788","DOI":"10.1097\/MD.0000000000024788","article-title":"Cardiovascular syphilis-associated acute myocardial infarction","volume":"100","author":"Li","year":"2021","journal-title":"Medicine (Baltimore)"},{"key":"2024050717420691000_ehae183-B6","doi-asserted-by":"crossref","first-page":"241","DOI":"10.5694\/j.1326-5377.2006.tb00214.x","article-title":"A pox on the heart: five cases of cardiovascular syphilis","volume":"184","author":"Tong","year":"2006","journal-title":"Med J Aust"},{"key":"2024050717420691000_ehae183-B7","first-page":"545","article-title":"Auricular fibrillation; 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