{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:01:38Z","timestamp":1792681298394,"version":"4.5.0"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"25","license":[{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Coexisting atrial fibrillation (AF) and cancer challenge the management of both. The aim of the study is to comprehensively provide the epidemiology of coexisting AF and cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using Dutch nationwide statistics, individuals with incident AF (n = 320 139) or cancer (n = 472 745) were identified during the period 2015\u201319. Dutch inhabitants without a history of AF (n = 320 135) or cancer (n = 472 741) were matched as control cohorts by demographic characteristics. Prevalence of cancer\/AF at baseline, 1-year risk of cancer\/AF diagnosis, and their time trends were determined. The association of cancer\/AF diagnosis with all-cause mortality among those with AF\/cancer was estimated by using time-dependent Cox regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The rate of prevalence of cancer in the AF cohort was 12.6% (increasing from 11.9% to 13.2%) compared with 5.6% in the controls; 1-year cancer risk was 2.5% (stable over years) compared with 1.8% in the controls [adjusted hazard ratio (aHR) 1.52, 95% confidence interval (CI) 1.46\u20131.58], which was similar by cancer type. The rate of prevalence of AF in the cancer cohort was 7.5% (increasing from 6.9% to 8.2%) compared with 4.3% in the controls; 1-year AF risk was 2.8% (stable over years) compared with 1.2% in the controls (aHR 2.78, 95% CI 2.69\u20132.87), but cancers of the oesophagus, lung, stomach, myeloma, and lymphoma were associated with higher hazards of AF than other cancer types. Both cancer diagnosed after incident AF (aHR 7.77, 95% CI 7.45\u20138.11) and AF diagnosed after incident cancer (aHR 2.55, 95% CI 2.47\u20132.63) were associated with all-cause mortality, but the strength of the association varied by cancer type.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Atrial fibrillation and cancer were associated bidirectionally and were increasingly coexisting, but AF risk varied by cancer type. Coexisting AF and cancer were negatively associated with survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehae222","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T18:51:02Z","timestamp":1711479062000},"page":"2201-2213","source":"Crossref","is-referenced-by-count":46,"title":["Coexisting atrial fibrillation and cancer: time trends and associations with mortality in a nationwide Dutch study"],"prefix":"10.1093","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9669-0007","authenticated-orcid":false,"given":"Qingui","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology, Leiden University Medical Center , Albinusdreef 2, 2333 ZA Leiden , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nienke","family":"van Rein","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Leiden University Medical Center , Albinusdreef 2, 2333 ZA Leiden , The Netherlands"},{"name":"Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center , Albinusdreef 2, 2333 ZA Leiden , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2296-1828","authenticated-orcid":false,"given":"Tom","family":"van der Hulle","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Leiden University Medical Center , Albinusdreef 2, 2333 ZA Leiden , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius C","family":"Heemelaar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Lung Center, Leiden University Medical Center , Albinusdreef 2, 2333 ZA Leiden , The Netherlands"},{"name":"Cardiovascular Imaging Research Center, Division of Cardiology, and Department of Radiology, Massachusetts General Hospital , 55 Fruit St, Boston, MA 02114 , 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