{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:08:53Z","timestamp":1790845733317,"version":"4.1.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"23","license":[{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>Many adult patients with congenital heart disease (ACHD) are still afflicted by premature death. Previous reports suggested natriuretic peptides may identify ACHD patients with adverse outcome. The study investigated prognostic power of B-type natriuretic peptide (BNP) across the spectrum of ACHD in a large contemporary cohort.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The cohort included 3392 consecutive ACHD patients under long-term follow-up at a tertiary ACHD centre between 2006 and 2019. The primary study endpoint was all-cause mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 11 974 BNP measurements were analysed. The median BNP at baseline was 47 (24\u2013107) ng\/L. During a median follow-up of 8.6 years (29 115 patient-years), 615 (18.1%) patients died. On univariable and multivariable analysis, baseline BNP [hazard ratio (HR) 1.16, 95% confidence interval (CI) 1.15\u20131.18 and HR 1.13, 95% CI 1.08\u20131.18, respectively] and temporal changes in BNP levels (HR 1.22, 95% CI 1.19\u20131.26 and HR 1.19, 95% CI 1.12\u20131.26, respectively) were predictive of mortality (P &amp;lt; .001 for both) independently of congenital heart disease diagnosis, complexity, anatomic\/haemodynamic features, and\/or systolic systemic ventricular function. Patients within the highest quartile of baseline BNP (&amp;gt;107\u2005ng\/L) and those within the highest quartile of temporal BNP change (&amp;gt;35\u2005ng\/L) had significantly increased risk of death (HR 5.8, 95% CI 4.91\u20136.79, P &amp;lt; .001, and HR 3.6, 95% CI 2.93\u20134.40, P &amp;lt; .001, respectively).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Baseline BNP and temporal BNP changes are both significantly associated with all-cause mortality in ACHD independent of congenital heart disease diagnosis, complexity, anatomic\/haemodynamic features, and\/or systolic systemic ventricular function. B-type natriuretic peptide levels represent an easy to obtain and inexpensive marker conveying prognostic information and should be used for the routine surveillance of patients with ACHD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehae254","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T15:35:29Z","timestamp":1715700929000},"page":"2066-2075","source":"Crossref","is-referenced-by-count":18,"title":["B-type natriuretic peptide levels predict long-term mortality in a large cohort of adults with congenital heart disease"],"prefix":"10.1093","volume":"45","author":[{"given":"Yusuke","family":"Yumita","sequence":"first","affiliation":[{"name":"Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton and Harefield Hospitals, Guys & St Thomas\u2019s NHS Trust , Sydney Street, London SW3 6NP , UK"},{"name":"Division of Cardiovascular Medicine, National Defence Medical College , Saitama , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2529-1943","authenticated-orcid":false,"given":"Zhuoyuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton and Harefield Hospitals, Guys & St Thomas\u2019s NHS Trust , Sydney Street, London SW3 6NP , UK"},{"name":"Maternal-Fetal Medicine Center in Fetal Heart Disease, Beijing Anzhen Hospital, Capital Medical University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard-Paul","family":"Diller","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton and Harefield Hospitals, Guys & St Thomas\u2019s NHS Trust , Sydney Street, London SW3 6NP , UK"},{"name":"Department of Cardiology III\u2014Adult Congenital and Valvular Heart Disease, University Hospital Muenster , Muenster , Germany"},{"name":"National Heart & Lung Institute, Imperial College , Dovehouse St, London SW3 6LY , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3203-5430","authenticated-orcid":false,"given":"Aleksander","family":"Kempny","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton and Harefield Hospitals, Guys & St Thomas\u2019s NHS Trust , Sydney Street, London SW3 6NP , UK"},{"name":"National Heart & Lung Institute, Imperial College , Dovehouse St, London SW3 6LY , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0107-7996","authenticated-orcid":false,"given":"Isma","family":"Rafiq","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton and Harefield Hospitals, Guys & St Thomas\u2019s NHS Trust , Sydney Street, London SW3 6NP , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8613-8139","authenticated-orcid":false,"given":"Claudia","family":"Montanaro","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton and Harefield Hospitals, Guys & St Thomas\u2019s NHS Trust , Sydney Street, London SW3 6NP , UK"},{"name":"National Heart & Lung Institute, Imperial College , Dovehouse St, London SW3 6LY , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3394-5559","authenticated-orcid":false,"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton and Harefield Hospitals, Guys & St Thomas\u2019s NHS Trust , Sydney Street, London SW3 6NP , UK"},{"name":"National Heart & Lung Institute, Imperial College , Dovehouse St, London SW3 6LY , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Beijing Anzhen Hospital, Capital Medical University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Dimopoulos","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton and Harefield Hospitals, Guys & St Thomas\u2019s NHS Trust , Sydney Street, London SW3 6NP , UK"},{"name":"National Heart & Lung Institute, Imperial College , Dovehouse St, London SW3 6LY , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Niwa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St Luke\u2019s International Hospital , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A","family":"Gatzoulis","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton and Harefield Hospitals, Guys & St Thomas\u2019s NHS Trust , Sydney Street, London SW3 6NP , UK"},{"name":"National Heart & Lung Institute, Imperial College , Dovehouse St, London SW3 6LY , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8754-8156","authenticated-orcid":false,"given":"Margarita","family":"Brida","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton and Harefield Hospitals, Guys & St Thomas\u2019s NHS Trust , Sydney Street, London SW3 6NP , UK"},{"name":"National Heart & Lung Institute, Imperial College , Dovehouse St, London SW3 6LY , UK"},{"name":"Medical Faculty University of Rijeka , 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