{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:20:54Z","timestamp":1791883254476,"version":"4.3.4"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"26","license":[{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>Presentation, outcome, and management of females with degenerative mitral regurgitation (DMR) are undefined. We analysed sex-specific baseline clinical and echocardiographic characteristics at referral for DMR due to flail leaflets and subsequent management and outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In the Mitral Regurgitation International Database (MIDA) international registry, females were compared with males regarding presentation at referral, management, and outcome (survival\/heart failure), under medical treatment, post-operatively, and encompassing all follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>At referral, females (n = 650) vs. males (n = 1660) were older with more severe symptoms and higher MIDA score. Smaller cavity diameters belied higher cardiac dimension indexed to body surface area. Under conservative management, excess mortality vs. expected was observed in males [standardized mortality ratio (SMR) 1.45 (1.27\u20131.65), P &amp;lt; .001] but was higher in females [SMR 2.00 (1.67\u20132.38), P &amp;lt; .001]. Female sex was independently associated with mortality [adjusted hazard ratio (HR) 1.29 (1.04\u20131.61), P = .02], cardiovascular mortality [adjusted HR 1.58 (1.14\u20132.18), P = .007], and heart failure [adjusted HR 1.36 (1.02\u20131.81), P = .04] under medical management. Females vs. males were less offered surgical correction (72% vs. 80%, P &amp;lt; .001); however, surgical outcome, adjusted for more severe presentation in females, was similar (P \u2265 .09). Ultimately, overall outcome throughout follow-up was worse in females who displayed persistent excess mortality vs. expected [SMR 1.31 (1.16\u20131.47), P &amp;lt; .001], whereas males enjoyed normal life expectancy restoration [SMR 0.92 (0.85\u20130.99), P = .036].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Females with severe DMR were referred to tertiary centers at a more advanced stage, incurred higher mortality and morbidity under conservative management, and were offered surgery less and later after referral. Ultimately, these sex-related differences yielded persistent excess mortality despite surgery in females with DMR, while males enjoyed restoration of life expectancy, warranting imperative re-evaluation of sex-specific DMR management.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehae265","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T05:25:27Z","timestamp":1715837127000},"page":"2306-2316","source":"Crossref","is-referenced-by-count":27,"title":["Degenerative mitral regurgitation due to flail leaflet: sex-related differences in presentation, management, and outcomes"],"prefix":"10.1093","volume":"45","author":[{"given":"Jean-Fan\u00e7ois","family":"Avierinos","sequence":"first","affiliation":[{"name":"D\u00e9partement de Cardiologie, Centre Hospitalier Universitaire Timone, Assistance Publique H\u00f4pitaux de Marseille, Aix-Marseille Universit\u00e9 , 264 rue Saint-Pierre, 13005 Marseille , France"},{"name":"U1251 INSERM, Marseille Medical Genetics, Aix-Marseille Universit\u00e9 , 27 Bd Jean Moulin, 13385 Marseille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7867-3668","authenticated-orcid":false,"given":"Christophe","family":"Tribouilloy","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Cardiologie, Centre Hospitalier Universitaire d\u2019Amiens , Amiens , France"},{"name":"EA 7517, Jules Verne University of Picardie , Amiens , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Bursi","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Milan , Milano , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Grigioni","sequence":"additional","affiliation":[{"name":"Research Unit of Cardiovascular Science, Universit\u00e0 e Fondazione Policlinico Universitario Campus Bio-Medico , Roma , 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