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However, even surgical or interventional closure is associated with a very high mortality and currently no randomized controlled trials are available addressing the optimal treatment strategy of this disease. This state-of-the-art review and clinical consensus statement will outline the diagnosis, hemodynamic consequences and treatment strategies of ventricular septal defects complicating acute myocardial infarction with a focus on current available evidence and a focus on major research questions to fill the gap in evidence.<\/jats:p>","DOI":"10.1093\/eurheartj\/ehae363","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T17:16:58Z","timestamp":1716398218000},"page":"2478-2492","source":"Crossref","is-referenced-by-count":58,"title":["Ventricular septal defect complicating acute myocardial infarction: diagnosis and management. A Clinical Consensus Statement of the Association for Acute CardioVascular Care (ACVC) of the ESC, the European Association of Percutaneous Cardiovascular Interventions (EAPCI) of the ESC and the ESC Working Group on Cardiovascular Surgery"],"prefix":"10.1093","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4840-1172","authenticated-orcid":false,"given":"Florian","family":"Schlotter","sequence":"first","affiliation":[{"name":"Department of Internal Medicine\/Cardiology, Heart Center Leipzig at University of Leipzig , Leipzig ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1695-3378","authenticated-orcid":false,"given":"Kurt","family":"Huber","sequence":"additional","affiliation":[{"name":"Departments of Cardiology and Intensive Care Medicine, Clinic Ottakring and Sigmund Freud University, Medical School , Vienna 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