{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:13:49Z","timestamp":1791911629879,"version":"4.3.4"},"reference-count":43,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32HL007227"],"award-info":[{"award-number":["T32HL007227"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["L30HL165535"],"award-info":[{"award-number":["L30HL165535"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011561","name":"Georg und Bertha Schwyzer-Winiker Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011561","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007252","name":"Baugarten Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007252","id-type":"DOI","asserted-by":"publisher"}]},{"name":"USZ Foundation"},{"DOI":"10.13039\/501100004362","name":"Swiss Heart Foundation","doi-asserted-by":"publisher","award":["FF17019"],"award-info":[{"award-number":["FF17019"]}],"id":[{"id":"10.13039\/501100004362","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004362","name":"Swiss Heart Foundation","doi-asserted-by":"publisher","award":["FF21073"],"award-info":[{"award-number":["FF21073"]}],"id":[{"id":"10.13039\/501100004362","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["160327"],"award-info":[{"award-number":["160327"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","award":["R01HL164634"],"award-info":[{"award-number":["R01HL164634"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","award":["R01HL147064"],"award-info":[{"award-number":["R01HL147064"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMW","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Netherlands Cardiovascular Research Initiative"},{"DOI":"10.13039\/501100002996","name":"Dutch Heart Foundation","doi-asserted-by":"publisher","award":["PREDICT2 2018-30"],"award-info":[{"award-number":["PREDICT2 2018-30"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007155","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RE\/18\/4\/34215"],"award-info":[{"award-number":["RE\/18\/4\/34215"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/CRTF\/23\/24448"],"award-info":[{"award-number":["FS\/CRTF\/23\/24448"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013342","name":"NIHR Imperial College Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013342","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIHR Royal Brompton Biomedical Research Centre"},{"DOI":"10.13039\/501100000282","name":"Sir Jules Thorn Charitable Trust","doi-asserted-by":"publisher","award":["21JTA"],"award-info":[{"award-number":["21JTA"]}],"id":[{"id":"10.13039\/501100000282","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Alexander Jansons Myocarditis UK"},{"DOI":"10.13039\/501100000833","name":"Rosetrees Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Pathogenic desmoplakin (DSP) gene variants are associated with the development of a distinct form of arrhythmogenic cardiomyopathy known as DSP cardiomyopathy. Patients harbouring these variants are at high risk for sustained ventricular arrhythmia (VA), but existing tools for individualized arrhythmic risk assessment have proven unreliable in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients from the multi-national DSP-ERADOS (Desmoplakin SPecific Effort for a RAre Disease Outcome Study) Network patient registry who had pathogenic or likely pathogenic DSP variants and no sustained VA prior to enrolment were followed longitudinally for the development of first sustained VA event. Clinically guided, step-wise Cox regression analysis was used to develop a novel clinical tool predicting the development of incident VA. Model performance was assessed by c-statistic in both the model development cohort (n = 385) and in an external validation cohort (n = 86).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 471 DSP patients [mean age 37.8 years, 65.6% women, 38.6% probands, 26% with left ventricular ejection fraction (LVEF) &amp;lt; 50%] were followed for a median of 4.0 (interquartile range: 1.6\u20137.3) years; 71 experienced first sustained VA events {2.6% [95% confidence interval (CI): 2.0, 3.5] events\/year}. Within the development cohort, five readily available clinical parameters were identified as independent predictors of VA and included in a novel DSP risk score: female sex [hazard ratio (HR) 1.9 (95% CI: 1.1\u20133.4)], history of non-sustained ventricular tachycardia [HR 1.7 (95% CI: 1.1\u20132.8)], natural logarithm of 24-h premature ventricular contraction burden [HR 1.3 (95% CI: 1.1\u20131.4)], LVEF &amp;lt; 50% [HR 1.5 (95% CI: .95\u20132.5)], and presence of moderate to severe right ventricular systolic dysfunction [HR 6.0 (95% CI: 2.9\u201312.5)]. The model demonstrated good risk discrimination within both the development [c-statistic .782 (95% CI: .77\u2013.80)] and external validation [c-statistic .791 (95% CI: .75\u2013.83)] cohorts. The negative predictive value for DSP patients in the external validation cohort deemed to be at low risk for VA (&amp;lt;5% at 5 years; n = 26) was 100%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The DSP risk score is a novel model that leverages readily available clinical parameters to provide individualized VA risk assessment for DSP patients. This tool may help guide decision-making for primary prevention implantable cardioverter-defibrillator placement in this high-risk population and supports a gene-first risk stratification approach.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehae409","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T01:46:21Z","timestamp":1718761581000},"source":"Crossref","is-referenced-by-count":35,"title":["A novel tool for arrhythmic risk stratification in desmoplakin gene variant carriers"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5589-1216","authenticated-orcid":false,"given":"Richard T","family":"Carrick","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Johns Hopkins University , 601 North Caroline St., Baltimore, MD 21287 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3432-070X","authenticated-orcid":false,"given":"Alessio","family":"Gasperetti","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Johns Hopkins University , 601 North Caroline St., Baltimore, MD 21287 , USA"},{"name":"Department of Genetics, University Medical Center Utrecht, University of Utrecht , Utrecht , The Netherlands"},{"name":"Department of Cardiology, University Medical Center Utrecht, Utrecht University , Utrecht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8595-7212","authenticated-orcid":false,"given":"Alexandros","family":"Protonotarios","sequence":"additional","affiliation":[{"name":"Inherited Cardiovascular Diseases Unit, St Bartholomew's Hospital, UCL Institute of Cardiovascular Science , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7870-8584","authenticated-orcid":false,"given":"Brittney","family":"Murray","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Johns Hopkins University , 601 North Caroline St., Baltimore, MD 21287 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7326-2656","authenticated-orcid":false,"given":"Mikael","family":"Laredo","sequence":"additional","affiliation":[{"name":"Institut de Cardiologie, Sorbonne Universit\u00e9, AP-HP, IHU-ICAN, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, Institut de Cardiologie , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0444-9994","authenticated-orcid":false,"given":"Iris","family":"van der Schaaf","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Utrecht, Utrecht University , Utrecht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0312-5354","authenticated-orcid":false,"given":"Dennis","family":"Dooijes","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Utrecht, Utrecht University , Utrecht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2363-8758","authenticated-orcid":false,"given":"Petros","family":"Syrris","sequence":"additional","affiliation":[{"name":"Inherited Cardiovascular Diseases Unit, St Bartholomew's Hospital, UCL Institute of Cardiovascular Science , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6298-922X","authenticated-orcid":false,"given":"Douglas","family":"Cannie","sequence":"additional","affiliation":[{"name":"Inherited Cardiovascular Diseases Unit, St Bartholomew's Hospital, UCL Institute of Cardiovascular Science , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3465-294X","authenticated-orcid":false,"given":"Crystal","family":"Tichnell","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Johns Hopkins University , 601 North Caroline St., Baltimore, MD 21287 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4511-8008","authenticated-orcid":false,"given":"Nisha A","family":"Gilotra","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Johns Hopkins University , 601 North Caroline St., Baltimore, MD 21287 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3102-3996","authenticated-orcid":false,"given":"Chiara","family":"Cappelletto","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Cardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina, University of Trieste , Trieste , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Medo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, University of Colorado Cardiovascular Institute, University of Colorado Anschutz Medical Campus , Aurora, CO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1896-0803","authenticated-orcid":false,"given":"Ardan M","family":"Saguner","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Arrhythmia Unit, University Heart Center, University Hospital Zurich , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4748-0158","authenticated-orcid":false,"given":"Firat","family":"Duru","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Arrhythmia Unit, University Heart Center, University Hospital Zurich , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8280-4541","authenticated-orcid":false,"given":"Robyn J","family":"Hylind","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Genetics, Boston Children\u2019s Hospital , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2113-4572","authenticated-orcid":false,"given":"Dominic J","family":"Abrams","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Genetics, Boston Children\u2019s Hospital , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6458-5421","authenticated-orcid":false,"given":"Neal K","family":"Lakdawala","sequence":"additional","affiliation":[{"name":"Center for Advanced Heart Disease, Brigham and Women's Hospital Cardiovascular Medicine , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7489-8744","authenticated-orcid":false,"given":"Julia","family":"Cadrin-Tourigny","sequence":"additional","affiliation":[{"name":"Cardiovascular Genetics Center, Montreal Heart Institute, Universit\u00e9 de Montr\u00e9al , Montr\u00e9al, QC , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9213-8565","authenticated-orcid":false,"given":"Mattia","family":"Targetti","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, Meyer Children Hospital, Careggi University Hospital , Florence , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1751-9266","authenticated-orcid":false,"given":"Iacopo","family":"Olivotto","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, Meyer Children Hospital, Careggi University Hospital , Florence , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4250-4859","authenticated-orcid":false,"given":"Maddalena","family":"Graziosi","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna , Bologna , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2825-8428","authenticated-orcid":false,"given":"Moniek","family":"Cox","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Centre Groningen , Groningen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0295-0440","authenticated-orcid":false,"given":"Elena","family":"Biagini","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna , Bologna , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1018-1231","authenticated-orcid":false,"given":"Philippe","family":"Charron","sequence":"additional","affiliation":[{"name":"Institut de Cardiologie, Sorbonne Universit\u00e9, AP-HP, IHU-ICAN, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, Institut de Cardiologie , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1924-6548","authenticated-orcid":false,"given":"Paolo","family":"Compagnucci","sequence":"additional","affiliation":[{"name":"Cardiology and Arrhythmology Clinic, University Hospital \u2018Ospedali Riuniti\u2019 , Ancona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5322-1742","authenticated-orcid":false,"given":"Michela","family":"Casella","sequence":"additional","affiliation":[{"name":"Cardiology and Arrhythmology Clinic, University Hospital \u2018Ospedali Riuniti\u2019 , Ancona , Italy"},{"name":"Department of Clinical, Special and Dental Sciences, Marche Polytechnic University , Ancona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2248-3456","authenticated-orcid":false,"given":"Giulio","family":"Conte","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale , Lugano , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6200-2114","authenticated-orcid":false,"given":"Claudio","family":"Tondo","sequence":"additional","affiliation":[{"name":"Department of Clinical Electrophysiology and Cardiac Pacing, Centro Cardiologico Monzino, Cen, IRCCS, University of Milan , Milan , Italy"},{"name":"Department of Biochemical, Surgical and Dentist Sciences, University of Milan , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1776-8070","authenticated-orcid":false,"given":"Momina","family":"Yazdani","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Heart and Lung Institute and and MRC London Institute of Medical Sciences , London , United Kingdom"},{"name":"Royal Brompton & Harefield Hospitals, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1847-4952","authenticated-orcid":false,"given":"James S","family":"Ware","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Heart and Lung Institute and and MRC London Institute of Medical Sciences , London , United Kingdom"},{"name":"Royal Brompton & Harefield Hospitals, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay K","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Heart and Lung Institute and and MRC London Institute of Medical Sciences , London , United Kingdom"},{"name":"Royal Brompton & Harefield Hospitals, Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6062-5286","authenticated-orcid":false,"given":"Leonardo","family":"Cal\u00f2","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Policlinico Casilino , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan , Ann Arbor , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam S","family":"Helms","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan , Ann Arbor , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9313-4172","authenticated-orcid":false,"given":"Sophie","family":"Hespe","sequence":"additional","affiliation":[{"name":"Centre for Population Genomics, Garvan Institute of Medical Research, UNSW Sydney , Sydney , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4846-7676","authenticated-orcid":false,"given":"Jodie","family":"Ingles","sequence":"additional","affiliation":[{"name":"Centre for Population Genomics, Garvan Institute of Medical Research, UNSW Sydney , Sydney , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harikrishna","family":"Tandri","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Johns Hopkins University , 601 North Caroline St., Baltimore, MD 21287 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavie","family":"Ader","sequence":"additional","affiliation":[{"name":"UF de Cardiog\u00e9n\u00e9tique et Myog\u00e9n\u00e9tique Mol\u00e9culaire et Cellulaire, APHP Sorbonne Universit\u00e9, DMU BioGem , 75013 Paris , France"},{"name":"Universit\u00e9 Paris Cit\u00e9, UFR de Pharmacie, UP Biochimie , 75006 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Peretto","sequence":"additional","affiliation":[{"name":"Department of Cardiac Electrophysiology and Arrhythmology, IRCCS San Raffaele Hospital , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Melbourne Hospital , Melbourne, Victoria 3050 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"Horton","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Melbourne Hospital , Melbourne, Victoria 3050 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Melbourne Hospital , Melbourne, Victoria 3050 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6884-2501","authenticated-orcid":false,"given":"Eric","family":"Schulze-Bahr","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Institute for Genetics of Heart Diseases, University Hospital M\u00fcnster , M\u00fcnster , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Dittman","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Institute for Genetics of Heart Diseases, University Hospital M\u00fcnster , M\u00fcnster , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D","family":"Carruth","sequence":"additional","affiliation":[{"name":"Department of Translational Data Science and Informatics, Geisinger , Danville, PA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katelyn","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Translational Data Science and Informatics, Geisinger , Danville, PA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Department of Translational Data Science and Informatics, Geisinger , Danville, PA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Haggerty","sequence":"additional","affiliation":[{"name":"Department of Translational Data Science and Informatics, Geisinger , Danville, PA , USA"},{"name":"The Heart Institute, Geisinger , Danville, PA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria N","family":"Parikh","sequence":"additional","affiliation":[{"name":"Stanford Center for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine , Stanford, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, University of Colorado Cardiovascular Institute, University of Colorado Anschutz Medical Campus , Aurora, CO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Mestroni","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, University of Colorado Cardiovascular Institute, University of Colorado Anschutz Medical Campus , Aurora, CO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Wilde","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Amsterdam UMC Location University of Amsterdam , Meibergdreef 9, Amsterdam , The Netherlands"},{"name":"Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias, Amsterdam UMC Location University of Amsterdam , Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2700-8478","authenticated-orcid":false,"given":"Gianfranco","family":"Sinagra","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Cardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina, University of Trieste , Trieste , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1022-3131","authenticated-orcid":false,"given":"Marco","family":"Merlo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Cardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina, University of Trieste , Trieste , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4846-5021","authenticated-orcid":false,"given":"Estelle","family":"Gandjbakhch","sequence":"additional","affiliation":[{"name":"Institut de Cardiologie, Sorbonne Universit\u00e9, AP-HP, IHU-ICAN, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, Institut de Cardiologie , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Peter","family":"van Tintelen","sequence":"additional","affiliation":[{"name":"Department of Genetics, University Medical Center Utrecht, University of Utrecht , Utrecht , The Netherlands"},{"name":"Netherlands Heart Institute , Utrecht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneline S J M","family":"te Riele","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Utrecht, Utrecht University , Utrecht , The Netherlands"},{"name":"Netherlands Heart Institute , Utrecht , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perry","family":"Elliott","sequence":"additional","affiliation":[{"name":"Inherited Cardiovascular Diseases Unit, St Bartholomew's Hospital, UCL Institute of Cardiovascular Science , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9262-9433","authenticated-orcid":false,"given":"Hugh","family":"Calkins","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Johns Hopkins University , 601 North Caroline St., Baltimore, MD 21287 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine C","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Johns Hopkins University , 601 North Caroline St., Baltimore, MD 21287 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0854-0418","authenticated-orcid":false,"given":"Cynthia A","family":"James","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Johns Hopkins University , 601 North Caroline St., Baltimore, MD 21287 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,16]]},"reference":[{"key":"2024080120563765900_ehae409-B1","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1083\/jcb.141.5.1229","article-title":"Defining the interactions between intermediate filaments and desmosomes","volume":"141","author":"Smith","year":"1998","journal-title":"J Cell Biol"},{"key":"2024080120563765900_ehae409-B2","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1086\/344208","article-title":"Mutation in human desmoplakin domain binding to plakoglobin causes a dominant form of arrhythmogenic right ventricular cardiomyopathy","volume":"71","author":"Rampazzo","year":"2002","journal-title":"Am J Hum Genet"},{"key":"2024080120563765900_ehae409-B3","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1093\/eurheartj\/ehq025","article-title":"Diagnosis of arrhythmogenic right ventricular cardiomyopathy\/dysplasia: proposed modification of the task force criteria","volume":"31","author":"Marcus","year":"2010","journal-title":"Eur Heart J"},{"key":"2024080120563765900_ehae409-B4","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1161\/CIRCULATIONAHA.119.044934","article-title":"Desmoplakin cardiomyopathy, a fibrotic and inflammatory form of cardiomyopathy distinct from typical dilated or arrhythmogenic right ventricular cardiomyopathy","volume":"141","author":"Smith","year":"2020","journal-title":"Circulation"},{"key":"2024080120563765900_ehae409-B5","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/j.hrthm.2024.03.279","article-title":"Clinical features and outcomes of 815 patients harboring desmoplakin pathogenic variants: gene-specific evaluation of a distinct clinical entity","volume":"21","author":"Gasperetti","year":"2024","journal-title":"Heart Rhythm"},{"key":"2024080120563765900_ehae409-B6","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.3390\/ijms24032490","article-title":"DSP-related cardiomyopathy as a distinct clinical entity? Emerging evidence from an Italian cohort","volume":"24","author":"Di Lorenzo","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2024080120563765900_ehae409-B7","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/europace\/euab183","article-title":"Clinical characteristics and risk stratification of desmoplakin cardiomyopathy","volume":"24","author":"Wang","year":"2022","journal-title":"Europace"},{"key":"2024080120563765900_ehae409-B8","doi-asserted-by":"crossref","first-page":"e301","DOI":"10.1016\/j.hrthm.2019.05.007","article-title":"2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy","volume":"16","author":"Towbin","year":"2019","journal-title":"Heart Rhythm"},{"key":"2024080120563765900_ehae409-B9","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1016\/j.jacc.2017.10.054","article-title":"2017 AHA\/ACC\/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society","volume":"72","author":"Al-Khatib","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2024080120563765900_ehae409-B10","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1093\/eurheartj\/ehac262","article-title":"2022 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death","volume":"43","author":"Zeppenfeld","year":"2022","journal-title":"Eur Heart J"},{"key":"2024080120563765900_ehae409-B11","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1093\/eurheartj\/ehz103","article-title":"A new prediction model for ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy","volume":"40","author":"Cadrin-Tourigny","year":"2019","journal-title":"Eur Heart J"},{"key":"2024080120563765900_ehae409-B12","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1093\/eurheartj\/ehac289","article-title":"Arrhythmic risk prediction in arrhythmogenic right ventricular cardiomyopathy: external validation of the arrhythmogenic right ventricular cardiomyopathy risk calculator","volume":"43","author":"Jord\u00e0","year":"2022","journal-title":"Eur Heart J"},{"key":"2024080120563765900_ehae409-B13","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.3390\/jcm11071973","article-title":"Validation of an arrhythmogenic right ventricular cardiomyopathy risk-prediction model in a Chinese cohort","volume":"11","author":"Zhang","year":"2022","journal-title":"J Clin Med"},{"key":"2024080120563765900_ehae409-B14","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.cjca.2021.02.018","article-title":"External validation of a risk prediction model for ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy","volume":"37","author":"Baudinaud","year":"2021","journal-title":"Can J Cardiol"},{"key":"2024080120563765900_ehae409-B15","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1016\/j.jacc.2020.04.023","article-title":"Prognostic value of magnetic resonance phenotype in patients with arrhythmogenic right ventricular cardiomyopathy","volume":"75","author":"Aquaro","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"2024080120563765900_ehae409-B16","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/europace\/euz352","article-title":"Long-term follow-up analysis of a highly characterized arrhythmogenic cardiomyopathy cohort with classical and non-classical phenotypes-a real-world assessment of a novel prediction model: does the subtype really matter","volume":"22","author":"Casella","year":"2020","journal-title":"Europace"},{"key":"2024080120563765900_ehae409-B17","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1093\/eurheartj\/ehac235","article-title":"Importance of genotype for risk stratification in arrhythmogenic right ventricular cardiomyopathy using the 2019 ARVC risk calculator","volume":"43","author":"Protonotarios","year":"2022","journal-title":"Eur Heart J"},{"key":"2024080120563765900_ehae409-B18","doi-asserted-by":"crossref","first-page":"100832","DOI":"10.1016\/j.jacadv.2024.100832","article-title":"Long-term arrhythmic follow-up and risk stratification of patients with desmoplakin-associated arrhythmogenic right ventricular cardiomyopathy","volume":"3","author":"Gasperetti","year":"2024","journal-title":"JACC Adv"},{"key":"2024080120563765900_ehae409-B19","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1161\/CIRCULATIONAHA.121.053521","article-title":"Phenotypic expression, natural history, and risk stratification of cardiomyopathy caused by filamin C truncating variants","volume":"144","author":"Gigli","year":"2021","journal-title":"Circulation"},{"key":"2024080120563765900_ehae409-B20","doi-asserted-by":"crossref","first-page":"e001603","DOI":"10.1161\/CIRCGENETICS.116.001603","article-title":"Gene-based risk stratification for cardiac disorders in LMNA mutation carriers","volume":"10","author":"Nishiuchi","year":"2017","journal-title":"Circ Cardiovasc Genet"},{"key":"2024080120563765900_ehae409-B21","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.1093\/eurheartj\/ehab294","article-title":"Prediction of ventricular arrhythmia in phospholamban p.Arg14del mutation carriers-reaching the frontiers of individual risk prediction","volume":"42","author":"Verstraelen","year":"2021","journal-title":"Eur Heart J"},{"key":"2024080120563765900_ehae409-B22","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"2024080120563765900_ehae409-B23","doi-asserted-by":"crossref","first-page":"e002467","DOI":"10.1161\/CIRCGEN.119.002467","article-title":"Arrhythmogenic right ventricular cardiomyopathy-associated desmosomal variants are rarely de novo","volume":"12","author":"van Lint","year":"2019","journal-title":"Circ Genom Precis Med"},{"key":"2024080120563765900_ehae409-B24","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1016\/j.jacc.2021.04.030","article-title":"Improved risk stratification for ventricular arrhythmias and sudden death in patients with nonischemic dilated cardiomyopathy","volume":"77","author":"Di Marco","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"2024080120563765900_ehae409-B25","doi-asserted-by":"crossref","first-page":"g7594","DOI":"10.1136\/bmj.g7594","article-title":"Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD statement","volume":"350","author":"Collins","year":"2015","journal-title":"BMJ"},{"key":"2024080120563765900_ehae409-B26","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.0006-341X.2000.00337.x","article-title":"Time-dependent ROC curves for censored survival data and a diagnostic marker","volume":"56","author":"Heagerty","year":"2000","journal-title":"Biometrics"},{"key":"2024080120563765900_ehae409-B27","doi-asserted-by":"crossref","first-page":"e011207","DOI":"10.1161\/CIRCEP.122.011207","article-title":"Longitudinal prediction of ventricular arrhythmic risk in patients with arrhythmogenic right ventricular cardiomyopathy","volume":"15","author":"Carrick","year":"2022","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2024080120563765900_ehae409-B28","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.hrthm.2018.01.031","article-title":"Predicting arrhythmic risk in arrhythmogenic right ventricular cardiomyopathy: a systematic review and meta-analysis","volume":"15","author":"Bosman","year":"2018","journal-title":"Heart Rhythm"},{"key":"2024080120563765900_ehae409-B29","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1002\/ehf2.12689","article-title":"Predicting sustained ventricular arrhythmias in dilated cardiomyopathy: a meta-analysis and systematic review","volume":"7","author":"Sammani","year":"2020","journal-title":"ESC Heart Fail"},{"key":"2024080120563765900_ehae409-B30","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1093\/eurheartj\/ehx011","article-title":"Sex hormones affect outcome in arrhythmogenic right ventricular cardiomyopathy\/dysplasia: from a stem cell derived cardiomyocyte-based model to clinical biomarkers of disease outcome","volume":"38","author":"Akdis","year":"2017","journal-title":"Eur Heart J"},{"key":"2024080120563765900_ehae409-B31","doi-asserted-by":"crossref","first-page":"e003302","DOI":"10.1161\/CIRCGEN.120.003302","article-title":"Clinical findings and diagnostic yield of arrhythmogenic cardiomyopathy through genomic screening of pathogenic or likely pathogenic desmosome gene variants","volume":"14","author":"Carruth","year":"2021","journal-title":"Circ Genom Precis Med"},{"key":"2024080120563765900_ehae409-B32","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1016\/j.jacc.2022.08.804","article-title":"Prognostic prediction of genotype vs phenotype in genetic cardiomyopathies","volume":"80","author":"Paldino","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"2024080120563765900_ehae409-B33","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1016\/j.jacc.2022.09.018","article-title":"Genotype-based risk stratification can outperform phenotype-based practice for inherited cardiomyopathies: not all paths are equal","volume":"80","author":"James","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"2024080120563765900_ehae409-B34","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1093\/eurheartj\/ehu284","article-title":"2014 ESC guidelines on diagnosis and management of hypertrophic cardiomyopathy: the task force for the diagnosis and management of hypertrophic cardiomyopathy of the European Society of Cardiology (ESC)","volume":"35","author":"Elliott","year":"2014","journal-title":"Eur Heart J"},{"key":"2024080120563765900_ehae409-B35","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1093\/eurheartj\/ehad799","article-title":"Implantable cardioverter defibrillator use in arrhythmogenic right ventricular cardiomyopathy in North America and Europe","volume":"45","author":"Carrick","year":"2024","journal-title":"Eur Heart J"},{"key":"2024080120563765900_ehae409-B36","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1093\/eurheartj\/ehad194","article-title":"2023 ESC guidelines for the management of cardiomyopathies","volume":"44","author":"Arbelo","year":"2023","journal-title":"Eur Heart J"},{"key":"2024080120563765900_ehae409-B37","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.hrthm.2020.03.007","article-title":"Novel risk calculator performance in athletes with arrhythmogenic right ventricular cardiomyopathy","volume":"17","author":"Gasperetti","year":"2020","journal-title":"Heart Rhythm"},{"key":"2024080120563765900_ehae409-B38","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/j.jacc.2013.06.033","article-title":"Exercise increases age-related penetrance and arrhythmic risk in arrhythmogenic right ventricular dysplasia\/cardiomyopathy-associated desmosomal mutation carriers","volume":"62","author":"James","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"2024080120563765900_ehae409-B39","doi-asserted-by":"crossref","first-page":"e015289","DOI":"10.1161\/JAHA.119.015289","article-title":"Familial recurrent myocarditis triggered by exercise in patients with a truncating variant of the desmoplakin gene","volume":"9","author":"Poller","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"2024080120563765900_ehae409-B40","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1001\/jamacardio.2021.6016","article-title":"Association of premature ventricular contraction burden on serial Holter monitoring with arrhythmic risk in patients with arrhythmogenic right ventricular cardiomyopathy","volume":"7","author":"Gasperetti","year":"2022","journal-title":"JAMA Cardiol"},{"key":"2024080120563765900_ehae409-B41","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1161\/CIRCULATIONAHA.122.060866","article-title":"Programmed ventricular stimulation as an additional primary prevention risk stratification tool in arrhythmogenic right ventricular cardiomyopathy: a multinational study","volume":"146","author":"Gasperetti","year":"2022","journal-title":"Circulation"},{"key":"2024080120563765900_ehae409-B42","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.jacep.2023.11.017","article-title":"Catheter ablation for ventricular tachycardia in patients with desmoplakin cardiomyopathy","volume":"10","author":"Gasperetti","year":"2024","journal-title":"JACC Clin Electrophysiol"},{"key":"2024080120563765900_ehae409-B43","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1161\/CIRCULATIONAHA.105.561571","article-title":"Are implantable cardioverter defibrillator shocks a surrogate for sudden cardiac death in patients with nonischemic cardiomyopathy?","volume":"113","author":"Ellenbogen","year":"2006","journal-title":"Circulation"}],"container-title":["European Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurheartj\/advance-article-pdf\/doi\/10.1093\/eurheartj\/ehae409\/58713006\/ehae409.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurheartj\/advance-article-pdf\/doi\/10.1093\/eurheartj\/ehae409\/58713006\/ehae409.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T18:05:16Z","timestamp":1722535516000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurheartj\/advance-article\/doi\/10.1093\/eurheartj\/ehae409\/7714395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,16]]},"references-count":43,"URL":"https:\/\/doi.org\/10.1093\/eurheartj\/ehae409","relation":{},"ISSN":["0195-668X","1522-9645"],"issn-type":[{"value":"0195-668X","type":"print"},{"value":"1522-9645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,16]]},"article-number":"ehae409"}}