{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:09:24Z","timestamp":1789517364610,"version":"build-2803163510"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"40","license":[{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08HL159346"],"award-info":[{"award-number":["K08HL159346"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Walter-Benjamin Fellowship from the Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["521832260"],"award-info":[{"award-number":["521832260"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006691","name":"John S. LaDue Memorial Fellowship in Cardiovascular Medicine from Harvard Medical School","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["18SFRN34110082"],"award-info":[{"award-number":["18SFRN34110082"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fredman Fellowship for Aortic Disease"},{"name":"Toomey Fund for Aortic Dissection Research"},{"DOI":"10.13039\/100004326","name":"Bayer AG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]},{"name":"AHA Strategically Focused Research Networks","award":["18SFRN34110082"],"award-info":[{"award-number":["18SFRN34110082"]}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["MAESTRIA 965286"],"award-info":[{"award-number":["MAESTRIA 965286"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Regional Medical Centers","award":["1 OT2 OD026549"],"award-info":[{"award-number":["1 OT2 OD026549"]}]},{"name":"Regional Medical Centers","award":["1 OT2 OD026554"],"award-info":[{"award-number":["1 OT2 OD026554"]}]},{"name":"Regional Medical Centers","award":["1 OT2 OD026557"],"award-info":[{"award-number":["1 OT2 OD026557"]}]},{"name":"Regional Medical Centers","award":["1 OT2 OD026556"],"award-info":[{"award-number":["1 OT2 OD026556"]}]},{"name":"Regional Medical Centers","award":["1 OT2 OD026550"],"award-info":[{"award-number":["1 OT2 OD026550"]}]},{"name":"Regional Medical Centers","award":["1 OT2 OD 026552"],"award-info":[{"award-number":["1 OT2 OD 026552"]}]},{"name":"Regional Medical Centers","award":["1 OT2 OD026553"],"award-info":[{"award-number":["1 OT2 OD026553"]}]},{"name":"Regional Medical Centers","award":["1 OT2 OD026548"],"award-info":[{"award-number":["1 OT2 OD026548"]}]},{"name":"Regional Medical Centers","award":["1 OT2 OD026551"],"award-info":[{"award-number":["1 OT2 OD026551"]}]},{"name":"Regional Medical Centers","award":["1 OT2 OD026555"],"award-info":[{"award-number":["1 OT2 OD026555"]}]},{"name":"Regional Medical Centers","award":["AOD 16037"],"award-info":[{"award-number":["AOD 16037"]}]},{"name":"Regional Medical Centers","award":["HHSN 263201600085U"],"award-info":[{"award-number":["HHSN 263201600085U"]}]},{"name":"Regional Medical Centers","award":["5 U2C OD023196"],"award-info":[{"award-number":["5 U2C OD023196"]}]},{"name":"Regional Medical Centers","award":["1 U24 OD023121"],"award-info":[{"award-number":["1 U24 OD023121"]}]},{"name":"Regional Medical Centers","award":["U24 OD023176"],"award-info":[{"award-number":["U24 OD023176"]}]},{"name":"Regional Medical Centers","award":["1 U24 OD023163"],"award-info":[{"award-number":["1 U24 OD023163"]}]},{"name":"Regional Medical Centers","award":["3 OT2 OD023205"],"award-info":[{"award-number":["3 OT2 OD023205"]}]},{"name":"Regional Medical Centers","award":["3 OT2 OD023206"],"award-info":[{"award-number":["3 OT2 OD023206"]}]},{"name":"Regional Medical Centers","award":["1 OT2 OD025277"],"award-info":[{"award-number":["1 OT2 OD025277"]}]},{"name":"Regional Medical Centers","award":["3 OT2 OD025315"],"award-info":[{"award-number":["3 OT2 OD025315"]}]},{"name":"Regional Medical Centers","award":["1 OT2 OD025337"],"award-info":[{"award-number":["1 OT2 OD025337"]}]},{"name":"Regional Medical Centers","award":["1 OT2 OD025276"],"award-info":[{"award-number":["1 OT2 OD025276"]}]},{"DOI":"10.13039\/100000050","name":"Framingham Heart Study of the National Heart Lung and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007265","name":"Boston University School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012737","name":"Department of Health and Human Services","doi-asserted-by":"publisher","award":["75N92019D00031"],"award-info":[{"award-number":["75N92019D00031"]}],"id":[{"id":"10.13039\/100012737","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>This study assessed whether a model incorporating clinical features and a polygenic score for ascending aortic diameter would improve diameter estimation and prediction of adverse thoracic aortic events over clinical features alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Aortic diameter estimation models were built with a 1.1 million-variant polygenic score (AORTA Gene) and without it. Models were validated internally in 4394 UK Biobank participants and externally in 5469 individuals from Mass General Brigham (MGB) Biobank, 1298 from the Framingham Heart Study (FHS), and 610 from All of Us. Model fit for adverse thoracic aortic events was compared in 401 453 UK Biobank and 164 789 All of Us participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>AORTA Gene explained more of the variance in thoracic aortic diameter compared to clinical factors alone: 39.5% (95% confidence interval 37.3%\u201341.8%) vs. 29.3% (27.0%\u201331.5%) in UK Biobank, 36.5% (34.4%\u201338.5%) vs. 32.5% (30.4%\u201334.5%) in MGB, 41.8% (37.7%\u201345.9%) vs. 33.0% (28.9%\u201337.2%) in FHS, and 34.9% (28.8%\u201341.0%) vs. 28.9% (22.9%\u201335.0%) in All of Us. AORTA Gene had a greater area under the receiver operating characteristic curve for identifying diameter \u2265 4 cm: 0.836 vs. 0.776 (P &amp;lt; .0001) in UK Biobank, 0.808 vs. 0.767 in MGB (P &amp;lt; .0001), 0.856 vs. 0.818 in FHS (P &amp;lt; .0001), and 0.827 vs. 0.791 (P = .0078) in All of Us. AORTA Gene was more informative for adverse thoracic aortic events in UK Biobank (P = .0042) and All of Us (P = .049).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A comprehensive model incorporating polygenic information and clinical risk factors explained 34.9%\u201341.8% of the variation in ascending aortic diameter, improving the identification of ascending aortic dilation and adverse thoracic aortic events compared to clinical risk factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehae474","type":"journal-article","created":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T01:25:49Z","timestamp":1720833949000},"page":"4318-4332","source":"Crossref","is-referenced-by-count":31,"title":["The AORTA Gene score for detection and risk stratification of ascending aortic dilation"],"prefix":"10.1093","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6088-4037","authenticated-orcid":false,"given":"James P","family":"Pirruccello","sequence":"first","affiliation":[{"name":"Division of Cardiology, University of California San Francisco , 555 Mission Bay Blvd South #3118, San Francisco, CA 94158 ,","place":["USA"]},{"name":"Institute for Human Genetics, University of California San Francisco , San Francisco, CA 94158 ,","place":["USA"]},{"name":"Bakar Computational Health Sciences Institute, University of California San Francisco , San Francisco, CA 94158 ,","place":["USA"]},{"name":"Cardiovascular Genetics Center, University of California San Francisco , San Francisco, CA 94158 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2840-4539","authenticated-orcid":false,"given":"Shaan","family":"Khurshid","sequence":"additional","affiliation":[{"name":"Cardiology Division, Massachusetts General Hospital , 55 Fruit Street, Boston, MA 02114 ,","place":["USA"]},{"name":"Cardiovascular Research Center, Massachusetts General Hospital , Boston, MA 02114 ,","place":["USA"]},{"name":"Demoulas Center for Cardiac Arrhythmias, Massachusetts General Hospital , Boston, MA 02114 ,","place":["USA"]},{"name":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard , Cambridge, MA 02142 ,","place":["USA"]},{"name":"Harvard Medical School , 25 Shattuck Street, Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghuang","family":"Lin","sequence":"additional","affiliation":[{"name":"Framingham Heart Study, Boston University and National Heart, Lung, and Blood Institute , Framingham, MA ,","place":["USA"]},{"name":"Department of Medicine, University of Massachusetts Chan Medical School , Worcester, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-Chen","family":"Weng","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Massachusetts General Hospital , Boston, MA 02114 ,","place":["USA"]},{"name":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard , Cambridge, MA 02142 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3742-4320","authenticated-orcid":false,"given":"Siavash","family":"Zamirpour","sequence":"additional","affiliation":[{"name":"School of Medicine, University of California San Francisco , San Francisco, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinwan","family":"Kany","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard , Cambridge, MA 02142 ,","place":["USA"]},{"name":"Department of Cardiology, University Heart and Vascular Center Hamburg-Eppendorf , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avanthi","family":"Raghavan","sequence":"additional","affiliation":[{"name":"Cardiology Division, Massachusetts General Hospital , 55 Fruit Street, Boston, MA 02114 ,","place":["USA"]},{"name":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard , Cambridge, MA 02142 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Koyama","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Massachusetts General Hospital , Boston, MA 02114 ,","place":["USA"]},{"name":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard , Cambridge, MA 02142 ,","place":["USA"]},{"name":"Laboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences , Kanagawa, Yokohama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramachandran S","family":"Vasan","sequence":"additional","affiliation":[{"name":"Framingham Heart Study, Boston University and National Heart, Lung, and Blood Institute , Framingham, MA ,","place":["USA"]},{"name":"Department of Medicine, Cardiology and Preventive Medicine Sections, Boston Medical Center, Boston University Chobanian and Avedisian School of Medicine , Boston, MA ,","place":["USA"]},{"name":"Epidemiology Department, Boston University School of Public Health , Boston, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emelia J","family":"Benjamin","sequence":"additional","affiliation":[{"name":"Framingham Heart Study, Boston University and National Heart, Lung, and Blood Institute , Framingham, MA ,","place":["USA"]},{"name":"Department of Medicine, Cardiology and Preventive Medicine Sections, Boston Medical Center, Boston University Chobanian and Avedisian School of Medicine , Boston, MA ,","place":["USA"]},{"name":"Epidemiology Department, Boston University School of Public Health , Boston, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E","family":"Lindsay","sequence":"additional","affiliation":[{"name":"Cardiology Division, Massachusetts General Hospital , 55 Fruit Street, Boston, MA 02114 ,","place":["USA"]},{"name":"Cardiovascular Research Center, Massachusetts General Hospital , Boston, MA 02114 ,","place":["USA"]},{"name":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard , Cambridge, MA 02142 ,","place":["USA"]},{"name":"Harvard Medical School , 25 Shattuck Street, Boston, MA 02115 ,","place":["USA"]},{"name":"Thoracic Aortic Center, Massachusetts General Hospital , Boston, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2067-0533","authenticated-orcid":false,"given":"Patrick T","family":"Ellinor","sequence":"additional","affiliation":[{"name":"Cardiology Division, Massachusetts General Hospital , 55 Fruit Street, Boston, MA 02114 ,","place":["USA"]},{"name":"Cardiovascular Research Center, Massachusetts General Hospital , Boston, MA 02114 ,","place":["USA"]},{"name":"Demoulas Center for Cardiac Arrhythmias, Massachusetts General Hospital , Boston, MA 02114 ,","place":["USA"]},{"name":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard , Cambridge, MA 02142 ,","place":["USA"]},{"name":"Harvard Medical School , 25 Shattuck Street, Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,12]]},"reference":[{"key":"2026041420151281300_ehae474-B1","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.1161\/CIRCULATIONAHA.112.000483","article-title":"Population-based study of incidence and outcome of acute aortic dissection and premorbid risk factor control: 10-year results from the Oxford Vascular Study","volume":"127","author":"Howard","year":"2013","journal-title":"Circulation"},{"key":"2026041420151281300_ehae474-B2","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1093\/ehjacc\/zuab031","article-title":"Population-based incidence and outcomes of acute aortic dissection in Japan","volume":"10","author":"Yamaguchi","year":"2021","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"2026041420151281300_ehae474-B3","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1016\/j.jacc.2016.06.025","article-title":"Risk of aortic dissection in the moderately dilated ascending aorta","volume":"68","author":"Kim","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"2026041420151281300_ehae474-B4","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1001\/jamacardio.2022.3305","article-title":"Association of thoracic aortic aneurysm size with long-term patient outcomes: the KP-TAA study","volume":"7","author":"Solomon","year":"2022","journal-title":"JAMA Cardiology"},{"key":"2026041420151281300_ehae474-B5","doi-asserted-by":"publisher","first-page":"e334","DOI":"10.1161\/CIR.0000000000001106","article-title":"2022 ACC\/AHA guideline for the diagnosis and management of aortic disease: a report of the American Heart Association\/American College of Cardiology Joint Committee on Clinical Practice Guidelines","volume":"146","author":"Isselbacher","year":"2022","journal-title":"Circulation"},{"key":"2026041420151281300_ehae474-B6","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1161\/CIRCULATIONAHA.107.702720","article-title":"Aortic diameter &gt;or = 5.5 cm is not a good predictor of type A aortic dissection: observations from the International Registry of Acute Aortic Dissection (IRAD)","volume":"116","author":"Pape","year":"2007","journal-title":"Circulation"},{"key":"2026041420151281300_ehae474-B7","doi-asserted-by":"publisher","first-page":"2873","DOI":"10.1093\/eurheartj\/ehu281","article-title":"2014 ESC guidelines on the diagnosis and treatment of aortic diseases: document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. The Task Force for the Diagnosis and Treatment of Aortic Diseases of the European Society of Cardiology (ESC)","volume":"35","author":"Erbel","year":"2014","journal-title":"Eur Heart J"},{"key":"2026041420151281300_ehae474-B8","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.1093\/eurheartj\/ehq258","article-title":"Cardiovascular manifestations in men and women carrying a FBN1 mutation","volume":"31","author":"D\u00e9taint","year":"2010","journal-title":"Eur Heart J"},{"key":"2026041420151281300_ehae474-B9","doi-asserted-by":"publisher","first-page":"e022102","DOI":"10.1161\/JAHA.121.022102","article-title":"Development and validation of a predictive model to identify patients with an ascending thoracic aortic aneurysm","volume":"10","author":"Mori","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"2026041420151281300_ehae474-B10","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.jacc.2021.04.094","article-title":"Population-based risk factors for ascending, arch, descending, and abdominal aortic dilations for 60\u201374\u2013year-old individuals","volume":"78","author":"Obel","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"2026041420151281300_ehae474-B11","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1001\/jama.2022.19701","article-title":"Development of a prediction model for ascending aortic diameter among asymptomatic individuals","volume":"328","author":"Pirruccello","year":"2022  15","journal-title":"JAMA"},{"key":"2026041420151281300_ehae474-B12","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1038\/s41588-021-00962-4","article-title":"Deep learning enables genetic analysis of the human thoracic aorta","volume":"54","author":"Pirruccello","year":"2022;","journal-title":"Nat Genet"},{"key":"2026041420151281300_ehae474-B13","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1038\/s41588-022-01070-7","article-title":"High heritability of ascending aortic diameter and trans-ancestry prediction of thoracic aortic disease","volume":"54","author":"Tcheandjieu","year":"2022","journal-title":"Nat Genet"},{"key":"2026041420151281300_ehae474-B14","doi-asserted-by":"publisher","first-page":"55","DOI":"10.7326\/M14-0697","article-title":"Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD): the TRIPOD statement","volume":"162","author":"Collins","year":"2015","journal-title":"Ann Intern Med"},{"key":"2026041420151281300_ehae474-B15","author":"Collins"},{"key":"2026041420151281300_ehae474-B16","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1056\/NEJMsr1809937","article-title":"The \u201cAll of Us\u201d Research Program","volume":"381","author":"Denny","year":"2019","journal-title":"N Engl J Med"},{"key":"2026041420151281300_ehae474-B17","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1016\/j.amjcard.2013.01.306","article-title":"Distribution, determinants, and normal reference values of thoracic and abdominal aortic diameters by computed tomography (from the Framingham Heart Study)","volume":"111","author":"Rogers","year":"2013","journal-title":"Am J Cardiol"},{"key":"2026041420151281300_ehae474-B18","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1016\/j.jacc.2023.01.044","article-title":"The genetic determinants of aortic distention","volume":"81","author":"Pirruccello","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"2026041420151281300_ehae474-B19","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41746-022-00590-0","article-title":"Cohort design and natural language processing to reduce bias in electronic health records research","volume":"5","author":"Khurshid","year":"2022","journal-title":"NPJ Digit Med"},{"key":"2026041420151281300_ehae474-B20","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1038\/s41467-019-09718-5","article-title":"Polygenic prediction via Bayesian regression and continuous shrinkage priors","volume":"10","author":"Ge","year":"2019","journal-title":"Nat Commun"},{"key":"2026041420151281300_ehae474-B21","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/s41586-018-0579-z","article-title":"The UK Biobank resource with deep phenotyping and genomic data","volume":"562","author":"Bycroft","year":"2018","journal-title":"Nature"},{"key":"2026041420151281300_ehae474-B22","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3390\/jpm6010002","article-title":"Building the Partners HealthCare Biobank at Partners personalized medicine: informed consent, return of research results, recruitment lessons and operational considerations","volume":"6","author":"Karlson","year":"2016","journal-title":"J Pers Med"},{"key":"2026041420151281300_ehae474-B23","doi-asserted-by":"publisher","first-page":"e1008500","DOI":"10.1371\/journal.pgen.1008500","article-title":"Use of &gt;100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic\/Latino populations","volume":"15","author":"Kowalski","year":"2019","journal-title":"PLoS Genet."},{"key":"2026041420151281300_ehae474-B24","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/nature09298","article-title":"Integrating common and rare genetic variation in diverse human populations","volume":"467","author":"Altshuler","year":"2010","journal-title":"Nature"},{"key":"2026041420151281300_ehae474-B25","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1002\/gepi.20533","article-title":"MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes","volume":"34","author":"Li","year":"2010","journal-title":"Genet Epidemiol"},{"key":"2026041420151281300_ehae474-B26","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s13073-022-01031-z","article-title":"Whole-genome sequencing as an investigational device for return of hereditary disease risk and pharmacogenomic results as part of the All of US Research Program","volume":"14","author":"Venner","year":"2022","journal-title":"Genome Med"},{"key":"2026041420151281300_ehae474-B27","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1038\/s41586-023-06957-x","article-title":"Genomic data in the All of Us Research Program","volume":"627","author":"Bick","year":"2024","journal-title":"Nature"},{"key":"2026041420151281300_ehae474-B28","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1080\/10618600.2014.938812","article-title":"Learning interactions via hierarchical group-lasso regularization","volume":"24","author":"Lim","year":"2015","journal-title":"J Comput Graph Stat"},{"key":"2026041420151281300_ehae474-B29","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1016\/j.jtcvs.2017.10.140","article-title":"Height alone, rather than body surface area, suffices for risk estimation in ascending aortic aneurysm","volume":"155","author":"Zafar","year":"2018","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2026041420151281300_ehae474-B30","doi-asserted-by":"publisher","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"2026041420151281300_ehae474-B31","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/sim.4085","article-title":"Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers","volume":"30","author":"Pencina","year":"2011","journal-title":"Stat Med"},{"key":"2026041420151281300_ehae474-B32","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4757-3294-8","volume-title":"Modeling Survival Data: Extending the Cox Model","author":"Therneau","year":"2000"},{"key":"2026041420151281300_ehae474-B33","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1093\/biomet\/89.3.635","article-title":"Comparing nonnested Cox models","volume":"89","author":"Fine","year":"2002","journal-title":"Biometrika"},{"key":"2026041420151281300_ehae474-B34","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.athoracsur.2005.06.026","article-title":"Novel measurement of relative aortic size predicts rupture of thoracic aortic aneurysms","volume":"81","author":"Davies","year":"2006","journal-title":"Ann Thorac Surg"},{"key":"2026041420151281300_ehae474-B35","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1038\/s41586-022-05275-y","article-title":"A saturated map of common genetic variants associated with human height","volume":"610","author":"Yengo","year":"2022","journal-title":"Nature"}],"container-title":["European Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/45\/40\/4318\/59920299\/ehae474.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/45\/40\/4318\/59920299\/ehae474.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:26:55Z","timestamp":1776212815000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurheartj\/article\/45\/40\/4318\/7731683"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,12]]},"references-count":35,"journal-issue":{"issue":"40","published-online":{"date-parts":[[2024,8,12]]},"published-print":{"date-parts":[[2024,10,21]]}},"URL":"https:\/\/doi.org\/10.1093\/eurheartj\/ehae474","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.08.23.23294513","asserted-by":"object"}]},"ISSN":["0195-668X","1522-9645"],"issn-type":[{"value":"0195-668X","type":"print"},{"value":"1522-9645","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,10,21]]},"published":{"date-parts":[[2024,8,12]]}}}