{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:54:06Z","timestamp":1793040846958,"version":"4.5.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"37","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070511"],"award-info":[{"award-number":["82070511"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270525"],"award-info":[{"award-number":["82270525"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972143"],"award-info":[{"award-number":["81972143"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172537"],"award-info":[{"award-number":["82172537"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["GA23C006"],"award-info":[{"award-number":["GA23C006"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"name":"China National Postdoctoral Program for Innovative Talents","award":["BX20230238"],"award-info":[{"award-number":["BX20230238"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Heart failure (HF) is a leading cause of mortality worldwide and characterized by significant co-morbidities and dismal prognosis. Neutrophil extracellular traps (NETs) aggravate inflammation in various cardiovascular diseases; however, their function and mechanism of action in HF pathogenesis remain underexplored. This study aimed to investigate the involvement of a novel VWF-SLC44A2-NET axis in HF progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>NET levels were examined in patients with HF and mouse models of transverse aortic constriction (TAC) HF. PAD4 knockout mice and NET inhibitors (GSK-484, DNase I, NEi) were used to evaluate the role of NETs in HF. RNA sequencing was used to investigate the downstream mechanisms. Recombinant human ADAMTS13 (rhADAMTS13), ADAMTS13, and SLC44A2 knockouts were used to identify novel upstream factors of NETs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Elevated NET levels were observed in patients with HF and TAC mouse models of HF. PAD4 knockout and NET inhibitors improved the cardiac function. Mechanistically, NETs induced mitochondrial dysfunction in cardiomyocytes, inhibiting mitochondrial biogenesis via the NE-TLR4-mediated suppression of PGC-1\u03b1. Furthermore, VWF\/ADAMTS13 regulated NET formation via SLC44A2. Additionally, sacubitril\/valsartan amplifies the cardioprotective effects of the VWF-SLC44A2-NET axis blockade.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study established the role of a novel VWF-SLC44A2-NET axis in regulating mitochondrial homeostasis and function, leading to cardiac apoptosis and contributing to HF pathogenesis. Targeting this axis may offer a potential therapeutic approach for HF treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehae517","type":"journal-article","created":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T18:08:02Z","timestamp":1722190082000},"page":"3853-3867","source":"Crossref","is-referenced-by-count":47,"title":["Von Willebrand factor exacerbates heart failure through formation of neutrophil extracellular traps"],"prefix":"10.1093","volume":"45","author":[{"given":"Ge","family":"Mang","sequence":"first","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University , Harbin 150086 ,","place":["China"]},{"name":"Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University , Beijing 100013 ,","place":["China"]},{"name":"The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD) , No. 246 Xuefu 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150086, Heilongjiang Province ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxuan","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University , Harbin 150086 ,","place":["China"]},{"name":"The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD) , No. 246 Xuefu Road, Nangang District, Harbin 150086, Heilongjiang Province ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University , Harbin 150086 ,","place":["China"]},{"name":"The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD) , No. 246 Xuefu Road, Nangang District, Harbin 150086, Heilongjiang Province ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghua","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University , Harbin 150086 ,","place":["China"]},{"name":"The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD) , No. 246 Xuefu Road, Nangang District, Harbin 150086, Heilongjiang Province ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University , Harbin 150086 ,","place":["China"]},{"name":"The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, State Key Laboratory of Frigid Zone Cardiovascular Diseases 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