{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:08:10Z","timestamp":1792598890468,"version":"4.5.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"40","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"China\u2019s National Key Research and Development Program","doi-asserted-by":"publisher","award":["2017YFC1700504"],"award-info":[{"award-number":["2017YFC1700504"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>Despite advances in technology and techniques, the recurrence rate of persistent atrial fibrillation (AF) following catheter ablation remains high. The Shensong Yangxin (SSYX) capsule, a renowned traditional Chinese medicine formula, is used in the treatment of cardiac arrhythmias. This trial aimed to investigate whether the SSYX can improve clinical outcomes in patients who have undergone catheter ablation for persistent AF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A multi-centre, randomized, double-blind, placebo-controlled clinical trial was conducted at 66 centres in China among 920 patients with persistent AF undergoing first ablation. Participants were randomized to oral SSYX, 1.6\u2005g (.4\u2005g\/granule) thrice daily (n = 460), or matched placebo (n = 460) for 12 months. The primary endpoint was recurrent atrial tachyarrhythmias lasting for \u226530\u2005s following a blanking period of 3 months. Secondary endpoints included time to first documented atrial tachyarrhythmias, AF burden, cardioversion, stroke\/systemic embolism, changes in echocardiographic parameters, and quality-of-life (QoL) score. Analyses were performed according to the intention-to-treat principle.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 920 patients underwent randomization (460 assigned to SSYX group and 460 assigned to placebo group). During the follow-up of 12 months, patients assigned to SSYX had a higher event-free rate from recurrent atrial tachyarrhythmias when compared with the placebo group (12-month Kaplan\u2013Meier event-free rate estimates, 85.5% and 77.7%, respectively; hazard ratio, .6; 95% confidence interval .4\u2013.8; P = .001). Patients assigned to receive SSYX had a better QoL score at 12 months compared to those randomized to placebo. There was no significant difference in the incidence of serious adverse events between the two groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Treatment with SSYX following radiofrequency catheter ablation for persistent AF reduced the incidence of recurrent atrial tachyarrhythmias and led to clinically significant improvements in QoL during a 12-month follow-up in a Chinese population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehae532","type":"journal-article","created":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T00:21:46Z","timestamp":1724458906000},"page":"4305-4314","source":"Crossref","is-referenced-by-count":24,"title":["Atrial tachyarrhythmia prevention by Shensong Yangxin after catheter ablation for persistent atrial fibrillation: the SS-AFRF trial"],"prefix":"10.1093","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3915-2733","authenticated-orcid":false,"given":"He","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Renmin Hospital of Wuhan University , 238 Jiefang Road, Wuhan 430060 ,","place":["China"]},{"name":"Cardiovascular Research Institute of Wuhan University , 238 Jiefang Road, Wuhan 430060 ,","place":["China"]},{"name":"Hubei Key Laboratory of Cardiology , 238 Jiefang Road, Wuhan 430060 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Renmin Hospital of Wuhan University , 238 Jiefang Road, Wuhan 430060 ,","place":["China"]},{"name":"Cardiovascular Research Institute of Wuhan University , 238 Jiefang Road, Wuhan 430060 ,","place":["China"]},{"name":"Hubei Key Laboratory of Cardiology , 238 Jiefang Road, Wuhan 430060 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Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine , Jinan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiufen","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Harbin Medical University , Harbin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Weihai Central Hospital , Weihai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Wannan Medical College , Wuhu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Hospital of Hebei Medical University , Shijiazhuang ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Hospital of China Medical University , Shenyang ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manhua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, General Hospital of Ningxia Medical University , Yinchuan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yao","sequence":"additional","affiliation":[{"name":"Peking University Clinical Research 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