{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:47:11Z","timestamp":1793933231120,"version":"4.8.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"45","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["ICI19\/00055"],"award-info":[{"award-number":["ICI19\/00055"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Severo Ochoa Centre for Excellence","award":["CEX2020-001041-S"],"award-info":[{"award-number":["CEX2020-001041-S"]}]},{"name":"Severo Ochoa Center of Excellence","award":["CEX2020-001041-S"],"award-info":[{"award-number":["CEX2020-001041-S"]}],"id":[{"id":"https:\/\/ror.org\/02y9qjz38","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Acute heart failure (AHF) promotes inflammatory activation, which is associated with worse outcomes. Colchicine has proven effective in other cardiovascular conditions characterized by inflammatory activation, but has never been evaluated in the setting of AHF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter, randomized, double-blind, and placebo-controlled trial included patients with AHF, requiring \u226540\u2005mg of intravenous furosemide, regardless of their left ventricular ejection fraction (LVEF) and inpatient or outpatient setting. Patients were randomized within the first 24\u2005h of presentation to receive either colchicine or placebo, with loading dose of 2\u2005mg, followed by 0.5\u2005mg every 12\u2005h for 8\u2005weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 278 patients [median age 75\u2005years, LVEF 40%, baseline N-terminal pro-B-type natriuretic peptide (NT-proBNP) 4262\u2005pg\/mL] were randomized to colchicine (n = 141) or placebo (n = 137). The primary endpoint, the time-averaged reduction in NT-proBNP levels at 8\u2005weeks, did not differ between the colchicine group [\u221262.2%, 95% confidence interval (CI) \u221268.9% to \u221254.2%] and the placebo group (\u221262.1%, 95% CI \u221268.6% to \u221254.3%) (ratio of change 1.0). The reduction in inflammatory markers was significantly greater with colchicine: ratio of change 0.60 (P &amp;lt; .001) for C-reactive protein and 0.72 (P = .019) for interleukin-6. No differences were found in new worsening heart failure episodes (14.9% with colchicine vs. 16.8% with placebo, P = .698); however, the need for intravenous furosemide during follow-up was lower with colchicine (P = .043). Diarrhea was slightly more common with colchicine, but it did not result in differences in medication withdrawal (8.5% vs. 8.8%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Colchicine was safe and effective in reducing inflammation in patients with AHF; however, colchicine and placebo exhibited comparable effects on reducing NT-proBNP and preventing new worsening heart failure events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehae538","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T19:45:36Z","timestamp":1723232736000},"page":"4826-4836","source":"Crossref","is-referenced-by-count":52,"title":["Colchicine in acutely decompensated heart failure: the COLICA trial"],"prefix":"10.1093","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4993-9540","authenticated-orcid":false,"given":"Domingo","family":"Pascual-Figal","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, IMIB Pascual Parrilla, Universidad de Murcia , Ctra. 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