{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T18:42:58Z","timestamp":1788460978529,"version":"build-2803163510"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"47","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100008322","name":"CSL Behring, LLC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>In the AEGIS-II trial (NCT03473223), CSL112, a human apolipoprotein A1 derived from plasma that increases cholesterol efflux capacity, did not significantly reduce the risk of the primary endpoint through 90\u2005days vs. placebo after acute myocardial infarction (MI). Nevertheless, given the well-established relationship between higher low-density lipoprotein cholesterol (LDL-C) and plaque burden, as well as greater risk reductions seen with PCSK9 inhibitors in patients with baseline LDL-C \u2265 100\u2005mg\/dL on statin therapy, the efficacy of CSL112 may be influenced by baseline LDL-C.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Overall, 18 219 patients with acute MI, multivessel coronary artery disease, and additional risk factors were randomized to either four weekly infusions of 6\u2005g CSL112 or placebo. This exploratory post-hoc analysis evaluated cardiovascular outcomes by baseline LDL-C in patients prescribed guideline-directed statin therapy at the time of randomization (n = 15 731).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>As baseline LDL-C increased, the risk of the primary endpoint at 90\u2005days lowered in those treated with CSL112 compared with placebo. In patients with LDL-C \u2265 100\u2005mg\/dL at randomization, there was a significant risk reduction of cardiovascular death, MI, or stroke in the CSL112 vs. placebo group at 90, 180, and 365\u2005days [hazard ratio .69 (.53\u2013.90), .71 (.57\u2013.88), and .78 (.65\u2013.93)]. In contrast, there was no difference between treatment groups among those with LDL-C &amp;lt; 100\u2005mg\/dL at baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this population, treatment with CSL112 compared to placebo was associated with a significantly lower risk of recurrent cardiovascular events among patients with a baseline LDL-C \u2265 100\u2005mg\/dL. Further studies need to confirm that CSL112 efficacy is influenced by baseline LDL-C.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehae614","type":"journal-article","created":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T11:25:17Z","timestamp":1724498717000},"page":"5023-5038","source":"Crossref","is-referenced-by-count":27,"title":["Apolipoprotein A-I infusions and cardiovascular outcomes in acute myocardial infarction according to baseline LDL-cholesterol levels: the AEGIS-II trial"],"prefix":"10.1093","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4857-9125","authenticated-orcid":false,"given":"C Michael","family":"Gibson","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School , 930 Commonwealth Avenue, Boston, MA 02215 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Duffy","sequence":"additional","affiliation":[{"name":"Clinical Development, CSL Behring, King of Prussia , PA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cecilia","family":"Bahit","sequence":"additional","affiliation":[{"name":"Cardiology Department, INECO Neurociencias Rosario , Rosario ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Chi","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School , 930 Commonwealth Avenue, Boston, MA 02215 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7712-6750","authenticated-orcid":false,"given":"Harvey","family":"White","sequence":"additional","affiliation":[{"name":"Health New Zealand - 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