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Accumulation of harmful blood signals may induce organotypic endothelial dysfunction affecting blood\u2013brain barrier function and vascular health in age-related diseases. Genetic-, age-, lifestyle- or cardiovascular therapy\u2013associated imbalance of amyloid-beta (A\u03b2) peptide metabolism in the brain and periphery may be the missing link between age-related neurocardiovascular diseases. Genetic polymorphisms of genes related to A\u03b2 metabolism, lifestyle modifications, drugs used in clinical practice, and A\u03b2-specific treatments may modulate A\u03b2 levels, affecting brain, vascular, and cardiac diseases. This narrative review elaborates on the effects of interventions on A\u03b2 metabolism in the brain, cerebrospinal fluid, blood, and peripheral heart or vascular tissues. Implications for clinical applicability, gaps in knowledge, and future perspectives of A\u03b2 as the link among age-related neurocardiovascular diseases are also discussed.<\/jats:p>","DOI":"10.1093\/eurheartj\/ehae655","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T16:08:17Z","timestamp":1731341297000},"page":"250-272","source":"Crossref","is-referenced-by-count":19,"title":["Amyloid-beta metabolism in age-related neurocardiovascular diseases"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9375-6119","authenticated-orcid":false,"given":"Evmorfia","family":"Aivalioti","sequence":"first","affiliation":[{"name":"Department of Clinical Therapeutics, National and Kapodistrian University of Athens Medical School , PO Box 11528, 80 Vas. 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Sofias Str., Athens ,","place":["Greece"]},{"name":"Division of Cardiology, Columbia University Irving Medical Center , New York, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7609-0087","authenticated-orcid":false,"given":"Dimitrios","family":"Delialis","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, National and Kapodistrian University of Athens Medical School , PO Box 11528, 80 Vas. Sofias Str., Athens ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kateryna","family":"Sopova","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Research, Medical Faculty Mannheim, Heidelberg University , Ludolf-Krehl-Stra\u00dfe 13\u201317, D-68167 Mannheim ,","place":["Germany"]},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site Heidelberg\/Mannheim , Mannheim ,","place":["Germany"]},{"name":"Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Heidelberg University , Theodor-Kutzer-Ufer 1-3, 68167 Mannheim ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1223-327X","authenticated-orcid":false,"given":"Stavros G","family":"Drakos","sequence":"additional","affiliation":[{"name":"Nora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah School of Medicine , Salt Lake City, UT ,","place":["USA"]},{"name":"Division of Cardiovascular Medicine, University of Utah School of Medicine , Salt Lake City, UT ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0194-0825","authenticated-orcid":false,"given":"Konstantinos","family":"Stellos","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University , Centre for Life, Newcastle Upon Tyne, NE1 3BZ ,","place":["UK"]},{"name":"Department of Cardiovascular Research, Medical Faculty Mannheim, Heidelberg University , Ludolf-Krehl-Stra\u00dfe 13\u201317, D-68167 Mannheim ,","place":["Germany"]},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site Heidelberg\/Mannheim , Mannheim ,","place":["Germany"]},{"name":"Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Heidelberg University , Theodor-Kutzer-Ufer 1-3, 68167 Mannheim ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6444-8734","authenticated-orcid":false,"given":"Kimon","family":"Stamatelopoulos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, National and Kapodistrian University of Athens Medical School , PO Box 11528, 80 Vas. 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