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When the mutation affects a \u2018driver\u2019 gene, the mutant clone gains a competitive advantage and has the potential to expand over time, a phenomenon referred to as clonal haematopoiesis (CH), which is emerging as a new risk factor for various non-haematological conditions, most notably cardiovascular disease (e.g. heart failure). Dilated cardiomyopathy (DCM) is a form of non-ischaemic heart failure that is characterized by a heterogeneous aetiology. The first evidence is arising that CH plays an important role in the disease course in patients with DCM, and a strong association of CH with multiple aetiologies of DCM has been described (e.g. inflammation, chemotherapy, and atrial fibrillation). The myocardial inflammation induced by CH may be an important trigger for DCM development for an already susceptible heart, e.g. in the presence of genetic variants, environmental triggers, and comorbidities. Studies investigating the role of CH in the pathogenesis of DCM are expected to increase rapidly. To move the field forward, it will be important to report the methodology and results in a standardized manner, so results can be combined and compared. The accurate measurement of CH in patients with DCM can provide guidance of specific (anti-inflammatory) therapies, as mutations in the CH driver genes prime the inflammasome pathway.<\/jats:p>","DOI":"10.1093\/eurheartj\/ehae682","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T07:20:05Z","timestamp":1728285605000},"page":"4797-4807","source":"Crossref","is-referenced-by-count":13,"title":["The emerging role of clonal haematopoiesis in the pathogenesis of dilated cardiomyopathy"],"prefix":"10.1093","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5549-1298","authenticated-orcid":false,"given":"Job A J","family":"Verdonschot","sequence":"first","affiliation":[{"name":"Department of Clinical Genetics, Maastricht University Medical Center+ , Maastricht ,","place":["the Netherlands"]},{"name":"Department of Cardiology, Maastricht University, Cardiovascular Research Institute Maastricht (CARIM) , P.O. Box 616, 6200 MD Maastricht ,","place":["the Netherlands"]},{"name":"European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart )"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose J","family":"Fuster","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC) , C. de Melchor Fern\u00e1ndez Almagro, 3, Fuencarral-El Pardo, 28029 Madrid ,","place":["Spain"]},{"name":"CIBER en Enfermedades Cardiovasculares (CIBER-CV) , Av. Monforte de Lemos, 3-5. Pabell\u00f3n 11, Planta 0, 28029 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7580-2276","authenticated-orcid":false,"given":"Kenneth","family":"Walsh","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine and Robert M. 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