{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T15:07:30Z","timestamp":1794409650514,"version":"4.9.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"46","license":[{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Stiftung Biomedizinische Alkoholforschung"},{"name":"Department of Medicine I, LMU University Hospital"},{"name":"Biotronik MT SE, Berlin, Germany"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>Acute excessive alcohol intake may cause the holiday heart syndrome, characterized by cardiac arrhythmias including atrial fibrillation. Since underlying data are scarce, the study aimed to prospectively investigate the temporal course of occurring cardiac arrhythmias following binge drinking in young adults.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 202 volunteers planning acute alcohol consumption with expected peak breath alcohol concentrations (BACs) of \u22651.2\u2005g\/kg were enrolled. The study comprised 48\u2005h electrocardiogram monitoring covering baseline (Hour 0), \u2018drinking period\u2019 (Hours 1\u20135), \u2018recovery period\u2019 (Hours 6\u201319), and two control periods corresponding to 24\u2005h after the \u2018drinking\u2019 and \u2018recovery periods\u2019, respectively. Acute alcohol intake was monitored by BAC measurements during the \u2018drinking period\u2019. Electrocardiograms were analysed for mean heart rate, atrial tachycardia, premature atrial complexes, premature ventricular complexes (PVCs), and heart rate variability measures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Data revealed an increase in heart rate and an excess of atrial tachycardias with increasing alcohol intake. Heart rate variability analysis indicated an autonomic modulation with sympathetic activation during alcohol consumption and the subsequent \u2018recovery period\u2019, followed by parasympathetic predominance thereafter. Premature atrial complexes occurred significantly more frequently in the \u2018control periods\u2019, whereas PVCs were more frequent in the \u2018drinking period\u2019. Ten participants experienced notable arrhythmic episodes, including atrial fibrillation and ventricular tachycardias, primarily during the \u2018recovery period\u2019.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The study demonstrates the impact of binge drinking on heart rate alterations and increased atrial tachycardias during \u2018drinking period\u2019, and the occurrence of clinically relevant arrhythmias during the \u2018recovery period\u2019, emphasizing the holiday heart syndrome as a health concern.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehae695","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T06:01:12Z","timestamp":1728021672000},"page":"4938-4949","source":"Crossref","is-referenced-by-count":22,"title":["Acute alcohol consumption and arrhythmias in young adults: the MunichBREW II 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