{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:04:50Z","timestamp":1792893890581,"version":"4.5.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital, Taiwan","doi-asserted-by":"publisher","award":["CORPG3N0281"],"award-info":[{"award-number":["CORPG3N0281"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital, Taiwan","doi-asserted-by":"publisher","award":["CORPG3M0371"],"award-info":[{"award-number":["CORPG3M0371"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital, Taiwan","doi-asserted-by":"publisher","award":["CMRPG3L0101"],"award-info":[{"award-number":["CMRPG3L0101"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital, Taiwan","doi-asserted-by":"publisher","award":["CMRPG3L0102"],"award-info":[{"award-number":["CMRPG3L0102"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital, Taiwan","doi-asserted-by":"publisher","award":["CMRPG3L0103"],"award-info":[{"award-number":["CMRPG3L0103"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital, Taiwan","doi-asserted-by":"publisher","award":["CFRPG3M0011"],"award-info":[{"award-number":["CFRPG3M0011"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital, Taiwan","doi-asserted-by":"publisher","award":["BMRPD95"],"award-info":[{"award-number":["BMRPD95"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC-112-2314-B-182A-107"],"award-info":[{"award-number":["NSTC-112-2314-B-182A-107"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC-113-2314-B-182A-017"],"award-info":[{"award-number":["NSTC-113-2314-B-182A-017"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>This study aimed to evaluate the association between pregnancy and aortic complications and determine related maternal and neonatal outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Records of pregnancies and neonatal deliveries from the Taiwan National Health Insurance Research Database from 2000 to 2020 were retrieved. The incidence rate ratio (IRR) was calculated to evaluate the risk factors for aortic events. Survival analysis was conducted to compare maternal and neonatal mortality with and without aortic events.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 4 785 266 pregnancies were identified among 2 833 271 childbearing women, and 2 852 449 delivered neonates. In the vulnerable and control periods, 57 and 20 aortic events occurred, resulting in incidence rates of 1.19 and 0.42 aortic events per 100 000 pregnancies, respectively. Pregnancy was established as a risk factor for aortic events (IRR: 2.86, P &amp;lt; .001). The 1-year maternal mortality rate was significantly higher in pregnancies with aortic events than in those without such events (19.3% vs. 0.05%, P &amp;lt; .001). Neonates whose mothers experienced aortic events had a higher late mortality (6.3% vs. 0.6%, P &amp;lt; .001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The association between pregnancy and aortic events was established in this study. The results revealed that women are at risk of aortic events from the gestational period to 1-year postpartum. Maternal mortality was significantly higher in pregnancies with aortic events than in those without. A higher late mortality and more complications were noted for neonatal deliveries with maternal aortic events. Early awareness of pregnant women at risk of aortic events\u2014especially those with concomitant hypertensive disorders of pregnancy, contributive family histories, or aortopathy\u2014is crucial.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehae757","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T02:57:27Z","timestamp":1731380247000},"page":"568-578","source":"Crossref","is-referenced-by-count":16,"title":["Pregnancy, aortic events, and neonatal and maternal outcomes"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1674-1295","authenticated-orcid":false,"given":"Shao-Wei","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Thoracic and Cardiovascular Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University , No. 5, Fuxing Street, Guishan District, Taoyuan City 33305 ,","place":["Taiwan"]},{"name":"Center for Big Data Analytics and Statistics, Chang Gung Memorial Hospital, Linkou Medical Center , No. 15, Wenhua 1st Rd., Guishan District, Taoyuan City 333011 ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4947-2896","authenticated-orcid":false,"given":"Feng-Cheng","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University , Taoyuan City ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University , Taoyuan City ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ting","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Cardiovascular Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University , No. 5, Fuxing Street, Guishan District, Taoyuan City 33305 ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1032-4979","authenticated-orcid":false,"given":"Fu-Chih","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University , Taoyuan City ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Chang","family":"Tung","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University , Taoyuan City ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Pin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University , Taoyuan City ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9918-4369","authenticated-orcid":false,"given":"Victor Chien-Chia","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University , Taoyuan City ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0361-6348","authenticated-orcid":false,"given":"Pao-Hsien","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University , Taoyuan City ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-Hsun","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Chang Gung Memorial 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