{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T09:11:19Z","timestamp":1793783479895,"version":"4.6.1"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"German Heart Center Munich"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Data from randomized trials investigating different access closure strategies after transfemoral transcatheter aortic valve implantation (TF-TAVI) remain scarce. In this study, two vascular closure device (VCD) strategies to achieve haemostasis after TF-TAVI were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The ACCESS-TAVI (Comparison of Strategies for Vascular ACCESS Closure after Transcatheter Aortic Valve Implantation) is a prospective, multicentre trial in which patients undergoing TF-TAVI were randomly assigned to a strategy with a combined suture-\/plug-based VCD strategy (suture\/plug group) using one ProGlide\u2122\/ProStyle\u2122 (Abbott Vascular) and one Angio-Seal\u00ae (Terumo) vs. a suture-based VCD strategy (suture-only group) using two ProGlides\u2122\/ProStyles\u2122. The primary endpoint was a composite of major or minor access site-related vascular complications during index hospitalization according to Valve Academic Research Consortium 3 criteria. Key secondary endpoints included time to haemostasis, bleeding type \u2265 2, and all-cause mortality over 30 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between September 2022 and April 2024, 454 patients were randomized. The primary endpoint occurred in 27% (62\/230) in the suture\/plug group and 54% (121\/224) in the suture-only group [relative risk .55 (95% confidence interval: .44, .68); P &amp;lt; .001]. Time to haemostasis was significantly shorter in the suture\/plug group compared with the suture-only group (108 \u00b1 208\u2005s vs. 206 \u00b1 171\u2005s; P &amp;lt; .001). At 30 days, bleeding type \u2265 2 occurred less often in the suture\/plug group compared with the suture-only group [6.2% vs. 12.1%, relative risk .66 (.43, 1.02); P = .032], with no significant difference in mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>With regard to the composite of major or minor access site-related vascular complications, a combined suture-\/plug-based VCD strategy was superior to a suture-based VCD strategy for vascular access closure in patients undergoing TF-TAVI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehae784","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T16:20:09Z","timestamp":1730218809000},"page":"635-645","source":"Crossref","is-referenced-by-count":48,"title":["Comparison of strategies for vascular ACCESS closure after Transcatheter Aortic Valve Implantation: the ACCESS-TAVI randomized trial"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3426-6080","authenticated-orcid":false,"given":"Tobias","family":"Rheude","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Diseases, German Heart Center Munich, Technical University Munich University Hospital , Lazarettstrasse 36, 80636 Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Ruge","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine & Health, Technical University of Munich , Lazarettstrasse 36, 80636 Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Altaner","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, German Heart Center Munich, Technical University Munich University 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