{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:34:34Z","timestamp":1793133274574,"version":"4.5.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>The increasing use of assisted reproductive technology (ART) has raised concerns regarding its long-term cardiovascular safety due to potential hormonal imbalances and pro-thrombotic states. This study aimed to assess the long-term cardiovascular risk associated with fertility treatments in women.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Following PRISMA guidelines, a systematic review and meta-analysis was conducted in MEDLINE (via PubMed) from inception to January 2024. Randomized, cohort, or case-control studies were included if fulfilling the following criteria: the association between ART and the subsequent cardiovascular outcome was reported and adjusted for confounding factors (at least age); the presence of a control group; and minimum 1-year follow-up. Effect size (ES) estimates of the association between fertility therapy and subsequent cardiovascular disease were pooled using the DerSimonian and Laird random-effects model. Heterogeneity was assessed with the I2 index. This study is registered on PROSPERO (CRD42024505605).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 7298 articles screened, 10 studies were included, encompassing 500 664 women undergoing ART and 36 395 240 controls. The analysis found no significant increase in the long-term risk of major adverse cardiovascular events [ES 1.04, 95% confidence interval (CI) 0.88\u20131.23, I2 87.61%, P = .63], coronary heart disease (ES 0.88, 95% CI 0.71\u20131.10, I2 24.36%, P = .26), stroke (ES 1.21, 95% CI 0.92\u20131.59, I2 70.40%, P = .17), venous thromboembolism (ES 0.95, 95% CI 0.70\u20131.28, I2 49.13%, P = .73), hypertension (ES 1.08, 95% CI 0.88\u20131.32, I2 94.63%, P = .46), or diabetes (ES 1.03, 95% CI 0.86\u20131.22, I2 78.44%, P = .77). Assisted reproductive technology was associated with a lower risk of heart failure (ES 0.75, 95% CI 0.60\u20130.94, I2 0.00%, P = .01).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Assisted reproductive technology use does not appear to be significantly associated with an increased long-term risk of cardiovascular diseases in women. While these findings suggest the cardiovascular safety of fertility treatments, further research is warranted.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehae886","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T20:26:47Z","timestamp":1733516807000},"page":"687-698","source":"Crossref","is-referenced-by-count":16,"title":["Cardiovascular safety of assisted reproductive technology: a meta-analysis"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5195-8815","authenticated-orcid":false,"given":"Carlo Andrea","family":"Pivato","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University , Via Rita Levi Montalcini 4, Pieve Emanuele, Milan 20072 ,","place":["Italy"]},{"name":"IRCCS Humanitas Research Hospital , Rozzano, Milan 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