{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:38:08Z","timestamp":1791959888827,"version":"4.3.4"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"19","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Cardiac Risk in the Young","award":["1050845"],"award-info":[{"award-number":["1050845"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>The feasibility and impact of high intensity exercise programmes in patients with hypertrophic cardiomyopathy (HCM) are unknown. This study was conducted to determine the feasibility of a high intensity exercise programme and explore safety and efficacy outcomes in patients with HCM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants were randomized to a 12-week supervised exercise programme (n = 40) in addition to usual care, or usual care alone (n = 40). All participants underwent assessment at baseline and 12 weeks. The exercise group was re-evaluated 6 months post-programme. Feasibility was assessed by (i) recruitment, adherence, and retention rates; (ii) staffing ratios; (iii) logistics; and (iv) acceptability of the intervention. The primary exploratory safety outcome was a composite of arrhythmia-related events. Exploratory secondary outcomes included changes in (i) cardiorespiratory fitness; (ii) cardiovascular risk factors; and (iii) quality of life, anxiety, and depression scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 67 (84%) participants completed the study (n = 34 and n = 33 in the exercise and usual care groups, respectively). Reasons for non-adherence included travel, work, and family commitments. Resource provision complied with national cardiac rehabilitation standards. There was no difference between groups for the exploratory safety outcome (P = .99). At 12 weeks, the exercise group had a greater increase in peak oxygen consumption (VO2) [+4.1\u2005mL\/kg\/min, 95% confidence interval (CI) 1.1, 7.1] and VO2 at anaerobic threshold (+2.3\u2005mL\/kg\/min, 95% CI 0.4, 4.1), lower systolic blood pressure (\u22127.3\u2005mmHg, 95% CI \u221211.7, \u22122.8) and body mass index (\u22120.8\u2005kg\/m2, 95% CI \u22121.1, \u22120.4), and greater improvement in hospital anxiety (\u22123, 95% CI \u22124.3, \u22121.7) and depression (\u22121.7, 95% CI \u22122.9, \u22120.5) scores, compared to the usual care group. Most exercise gains dissipated at 6 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A high intensity exercise programme is feasible in patients with HCM, with apparent cardiovascular and psychological benefits, and no increase in arrhythmias. A large-scale study is required to substantiate findings and assess long-term safety of high intensity exercise in HCM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehae919","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T15:32:35Z","timestamp":1734535955000},"page":"1803-1815","source":"Crossref","is-referenced-by-count":43,"title":["High intensity exercise programme in patients with hypertrophic cardiomyopathy: a randomized trial"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1339-665X","authenticated-orcid":false,"given":"Joyee","family":"Basu","sequence":"first","affiliation":[{"name":"Cardiovascular and Genomic Research Institute, City St George\u2019s, University of London , Cranmer Terrace, London SW17 0RE , \u2020","place":["UK"]},{"name":"Cardiovascular Clinical Academic Group, St George\u2019s University Hospitals NHS Foundation Trust , Blackshaw Road, London SW17 0QT , 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