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and mechanisms remain unclear. Given the presumed close association of neutrophils with both conditions, this study aims to elucidate the roles of neutrophils in mediating the interaction between PD and MI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Three prospective cohorts and PD + MI mouse model were investigated to assess the effects of PD on MI prognosis. Single-cell-RNA sequencing and genome-wide association study were employed to identify the neutrophil subtype involved. To characterize the function of SiglecF+ neutrophils, bone marrow transplantation, Edu-pulse chasing, lineage tracing, and collagen contraction assay were utilized. Adoptive neutrophil transfer, conditional Siglecf knockout and lipid nanoparticles facilitating local SiglecF+ neutrophils depletion was harnessed to explore the roles of SiglecF+ neutrophils in MI repair.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Persisting but not short-term PD upset MI prognosis (cardiac fibrosis and function) in human and mice. Bone marrow neutrophils of PD were intrinsically skewed toward longer-lived SiglecF+ neutrophil differentiation, a subtype that was converted by GMCSF or TGF\u03b2 in PPAR\u03b3-dependent manner. SiglecF+ neutrophils were expanded in infarcted PD heart where they deposit collagen and activate fibroblasts to instigate excessive fibrosis. SiglecF+ neutrophil depletion was efficacious for mitigating fibrosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study demonstrated that long-lasting PD-aggravated MI prognosis by expanding scar-associated SiglecF+ neutrophils into the heart and highlighted the clinical relevance of oral health examination for treating MI in a holistic fashion.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehaf049","type":"journal-article","created":{"date-parts":[[2025,1,26]],"date-time":"2025-01-26T04:17:55Z","timestamp":1737865075000},"page":"2223-2238","source":"Crossref","is-referenced-by-count":28,"title":["Periodontitis-related myocardial fibrosis by expansion of collagen-producing SiglecF+ neutrophils"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9149-7002","authenticated-orcid":false,"given":"Xuekui","family":"Wang","sequence":"first","affiliation":[{"name":"Shanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Oral Implantology, Shanghai Tongji Stomatological Hospital and Dental School, Tongji University , Shanghai 200072 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5953-4830","authenticated-orcid":false,"given":"Yue","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiology, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University , Shanghai 200092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0019-0014","authenticated-orcid":false,"given":"Canqing","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology & Biostatistics, School of Public Health, Peking University , Beijing 100191 ,","place":["China"]},{"name":"Peking University Center for Public Health and Epidemic Preparedness and Response , Beijing 100191 ,","place":["China"]},{"name":"Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education , Beijing 100191 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruhua","family":"Deng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiology, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University , Shanghai 200092 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