{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T09:26:18Z","timestamp":1784280378088,"version":"3.55.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"15","license":[{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>Rheumatic heart disease is the commonest acquired cardiovascular disease worldwide. About 20 years have elapsed since the original Euro Heart Survey on valvular heart disease (VHD) was conducted with multiple changes in practice due to advances in treatment techniques. In this study, we aimed to analyse the management of patients with severe native valve disease or those with previous valvular intervention in comparison with existing European Society of Cardiology guidelines.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The European Society of Cardiology VHD II registry is an international, prospective, longitudinal multicentre, observational study, which was conducted in 222 centres. The registry included patients with severe native VHD or with previous valvular intervention. Follow-up was undertaken at 6 months at the investigating centre or by telephone.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Amongst patients recruited in the European Society of Cardiology VHD II registry, 470 had severe rheumatic mitral valve disease and 332 had previous rheumatic mitral valve intervention. Amongst the patients with Class I recommendation for intervention, it was undertaken in only 70%. Adherence to guideline recommendations was more in patients with native VHD than in those with previous intervention. Total mortality was 1.5% in hospital and 3.5% at 6 months follow-up. Independent predictors of death at 6 months were age, chronic pulmonary disease, New York Heart Association Classes III and IV at presentation, liver dysfunction, and previous myocardial infarction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Compliance with guideline recommendations for intervention is poor overall in patients with rheumatic valve disease. Concerted educational efforts are needed to improve the management of this vulnerable patient cohort.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehaf050","type":"journal-article","created":{"date-parts":[[2025,1,26]],"date-time":"2025-01-26T04:19:29Z","timestamp":1737865169000},"page":"1431-1442","source":"Crossref","is-referenced-by-count":8,"title":["Baseline characteristics and outcomes of rheumatic mitral valve disease: the EURObservational Research Programme Valvular Heart Disease II Survey"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6701-7072","authenticated-orcid":false,"given":"Magdy","family":"Abdelhamid","sequence":"first","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Kasr Al Ainy, Cairo University , New Cairo, Le Rois, Villa 29 D, Cairo 11835 ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir M","family":"Abdel Meged","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Kasr Al Ainy, Cairo University , New Cairo, Le Rois, Villa 29 D, Cairo 11835 ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6031-2124","authenticated-orcid":false,"given":"Bernard","family":"Prendergast","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St Thomas\u2019 Hospital and Cleveland Clinic , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco E","family":"Calvo-Iglesias","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Alvaro Cunqueiro , Vigo ,","place":["Spain"]},{"name":"Cardiology Department, Hospital Vithas-Fatima , Vigo ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salma M","family":"Taha","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Assiut University , Assiut ,","place":["Egypt"]},{"name":"Department of Cardiovascular medicine, Sphinx University , New Assiut ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada A","family":"Kazamel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Heart Institute , Cairo ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa M","family":"Abdrabou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Kasr Al Ainy, Cairo University , New Cairo, Le Rois, Villa 29 D, Cairo 11835 ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maiy H","family":"El Sayed","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ain Shams University , Cairo ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minna M","family":"Kylmala","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Helsinki University Central Hospital , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga B","family":"Irtyuga","sequence":"additional","affiliation":[{"name":"Department of Congenital and Valvular Heart Diseases, Almazov National Medical Research Centre , St. Petersburg ,","place":["Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alec S","family":"Vahanian","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Universit\u00e9 Paris Cit\u00e9 Medecine , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Iung","sequence":"additional","affiliation":[{"name":"AP-HP Cardiology Department, Bichat Hospital, Universit\u00e9 Paris Cit\u00e9, INSERM 1148 , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Laroche","sequence":"additional","affiliation":[{"name":"EURObservational Research Programme, European Society of Cardiology , Sophia-Antipolis ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,2,11]]},"reference":[{"key":"2025041508423409900_ehaf050-B1","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/S1473-3099(05)70267-X","article-title":"The global burden of Group A streptococcal diseases","volume":"5","author":"Carapetis","year":"2005","journal-title":"Lancet Infect Dis"},{"key":"2025041508423409900_ehaf050-B2","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/j.1365-3156.2010.02670.x","article-title":"Systematic review: estimation of global burden of non-suppurative sequelae of upper respiratory tract infection: rheumatic fever and post-streptococcal glomerulonephritis","volume":"16","author":"Jackson","year":"2011","journal-title":"Trop Med Int Health"},{"key":"2025041508423409900_ehaf050-B3","first-page":"329","article-title":"Socioeconomic factors in the etiology of rheumatic fever","volume":"32","author":"Adanja","year":"1988","journal-title":"J Hyg Epidemiol Microbiol Immunol"},{"key":"2025041508423409900_ehaf050-B4","doi-asserted-by":"publisher","first-page":"67","DOI":"10.2147\/CLEP.S12977","article-title":"The worldwide epidemiology of acute rheumatic fever and rheumatic heart disease","volume":"3","author":"Seckeler","year":"2011","journal-title":"Clin Epidemiol"},{"key":"2025041508423409900_ehaf050-B5","doi-asserted-by":"publisher","first-page":"3584","DOI":"10.1161\/CIRCULATIONAHA.105.539775","article-title":"Rheumatic and nonrheumatic valvular heart disease: epidemiology, management, and prevention in Africa","volume":"112","author":"Essop","year":"2005","journal-title":"Circulation"},{"key":"2025041508423409900_ehaf050-B6","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1161\/CIRCULATIONAHA.119.041080","article-title":"Contemporary presentation and management of valvular heart disease: the EURObservational Research Programme Valvular Heart Disease II survey","volume":"140","author":"Iung","year":"2019","journal-title":"Circulation"},{"key":"2025041508423409900_ehaf050-B7","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1161\/CIRCULATIONAHA.115.020621","article-title":"Evolution of mitral valve prolapse: insights from the Framingham Heart Study","volume":"133","author":"Delling","year":"2016","journal-title":"Circulation"},{"key":"2025041508423409900_ehaf050-B8","doi-asserted-by":"publisher","first-page":"2194","DOI":"10.1093\/eurheartj\/ehz314","article-title":"Causes and mechanisms of isolated mitral regurgitation in the community: clinical context and outcome","volume":"40","author":"Dziadzko","year":"2019","journal-title":"Eur Heart J"},{"key":"2025041508423409900_ehaf050-B9","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","article-title":"Burden of valvular heart diseases: a population-based study","volume":"368","author":"Nkomo","year":"2006","journal-title":"Lancet"},{"key":"2025041508423409900_ehaf050-B10","doi-asserted-by":"publisher","first-page":"3515","DOI":"10.1093\/eurheartj\/ehw229","article-title":"Large-scale community echocardiographic screening reveals a major burden of undiagnosed valvular heart disease in older people: the OxVALVE population cohort study","volume":"37","author":"d\u2019Arcy","year":"2016","journal-title":"Eur Heart J"},{"key":"2025041508423409900_ehaf050-B11","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/j.ahj.2009.10.014","article-title":"Contemporary insights into the functional anatomy of the mitral valve","volume":"158","author":"Silbiger","year":"2009","journal-title":"Am Heart J"},{"key":"2025041508423409900_ehaf050-B12","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.jtcvs.2014.05.014","article-title":"2014 AHA\/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association task force on practice guidelines","volume":"148","author":"Nishimura","year":"2014","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2025041508423409900_ehaf050-B13","doi-asserted-by":"publisher","first-page":"2451","DOI":"10.1093\/eurheartj\/ehs109","article-title":"Guidelines on the management of valvular heart disease (version 2012): the Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"33","author":"Vahanian","year":"2012","journal-title":"Eur Heart J"},{"key":"2025041508423409900_ehaf050-B14","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"2021 ESC\/EACTS guidelines for the management of valvular heart disease","volume":"43","author":"Vahanian","year":"2021","journal-title":"Eur Heart J"},{"key":"2025041508423409900_ehaf050-B15","doi-asserted-by":"publisher","first-page":"e72","DOI":"10.1161\/CIR.0000000000000923","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease a report of the American College of Cardiology\/American Heart Association joint committee on clinical practice guidelines","volume":"143","author":"Otto","year":"2021","journal-title":"Circulation"},{"key":"2025041508423409900_ehaf050-B16","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/s0195-668x(03)00201-x","article-title":"A prospective survey of patients with valvular heart disease in Europe: The Euro Heart Survey on valvular heart disease","volume":"24","author":"Iung","year":"2003","journal-title":"Eur Heart J"},{"key":"2025041508423409900_ehaf050-B17","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1056\/NEJMoa2209051","article-title":"Rivaroxaban in rheumatic heart disease-associated atrial fibrillation","volume":"387","author":"Connolly","year":"2022","journal-title":"N Engl J Med"}],"container-title":["European Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurheartj\/advance-article-pdf\/doi\/10.1093\/eurheartj\/ehaf050\/61849827\/ehaf050.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurheartj\/advance-article-pdf\/doi\/10.1093\/eurheartj\/ehaf050\/61849827\/ehaf050.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T08:42:36Z","timestamp":1744706556000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurheartj\/article\/46\/15\/1431\/8008900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,11]]},"references-count":17,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2025,2,11]]},"published-print":{"date-parts":[[2025,4,15]]}},"URL":"https:\/\/doi.org\/10.1093\/eurheartj\/ehaf050","relation":{},"ISSN":["0195-668X","1522-9645"],"issn-type":[{"value":"0195-668X","type":"print"},{"value":"1522-9645","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,4,14]]},"published":{"date-parts":[[2025,2,11]]}}}