{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:24:28Z","timestamp":1793399068708,"version":"4.5.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"22","license":[{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>In acute coronary syndromes (ACS), vascular healing at the site of implantation of drug-eluting stents (DES) can be delayed. Titanium-nitride-oxide-coated stents (TiNOS) demonstrate faster strut coverage without the excessive intimal hyperplasia observed with bare metal stents. The 5-year outcomes of patients presenting with ACS, randomized to receive either TiNOS or DES, were compared.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A systematic review and individual participant data meta-analysis of trials comparing TiNOS with DES for the treatment of ACS was conducted (PROSPERO: CRD42024514342). The primary endpoint was major adverse cardiac events (MACE) at 5 years, a composite of cardiac death (CD), myocardial infarction (MI), and ischaemia-driven target lesion revascularization (TLR). Pre-specified secondary endpoints included CD, MI, TLR, and stent thrombosis. Data were pooled using a mixed-effects Cox regression model with random slope and stratified baseline hazards.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patient-level data (n = 2743) were obtained from three randomized controlled trials (TiNOS: n = 1620 vs. DES: n = 1123). After a median follow-up of 4.93 years, there was no significant difference in the primary endpoint between TiNOS and DES (12.6% vs. 16.2%; hazard ratio [HR] .82, 95% confidence interval [CI] .67\u20131.00, P = .051), mainly due to a similar rate of TLR (8.0% vs. 8.1%; HR 1.05, 95% CI .80\u20131.38, P = .733). However, TiNOS was associated with significantly lower rates of CD (1.5% vs. 3.7%; HR .46, 95% CI .26\u2013.81, P = .007), MI (5.2% vs. 9.6%; HR .56, 95% CI .42\u2013.75, P &amp;lt; .001), and stent thrombosis (1.1% vs. 3.8%; HR .30, 95% CI .17\u2013.53, P &amp;lt; .001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In ACS patients, TiNOS was associated with similar rates of MACE and TLR as compared with DES but significantly lower rates of CD, MI, and stent thrombosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehaf098","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:59:11Z","timestamp":1740142751000},"page":"2092-2100","source":"Crossref","is-referenced-by-count":8,"title":["Titanium-nitride-oxide-coated vs. drug-eluting stents in acute coronary syndromes: an individual patient data meta-analysis"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0025-8162","authenticated-orcid":false,"given":"Thabo","family":"Mahendiran","sequence":"first","affiliation":[{"name":"Cardiovascular Center Aalst, OLV Clinic , Aalst ,","place":["Belgium"]},{"name":"Department of Cardiology, Lausanne University Hospital , Lausanne ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Bouisset","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Aalst, OLV Clinic , Aalst ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pim","family":"Tonino","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Catharina Hospital , Eindhoven ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico H J","family":"Pijls","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Catharina Hospital , Eindhoven ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jussi","family":"Sia","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kokkola Central Hospital , Kokkola ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Kervinen","sequence":"additional","affiliation":[{"name":"Clinical Research Center, Oulu University Hospital , Oulu ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Rivero-Crespo","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Section, La Princesa University Hospital , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"J\u00fcni","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford , Oxford ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Roza da Costa","sequence":"additional","affiliation":[{"name":"Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford , Oxford ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5792-2549","authenticated-orcid":false,"given":"Carlos","family":"Collet","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Aalst, OLV Clinic , Aalst ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Mizukami","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Aalst, OLV Clinic , Aalst ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasi","family":"Karjalainen","sequence":"additional","affiliation":[{"name":"Heart and 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