{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T12:41:46Z","timestamp":1785760906535,"version":"3.56.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"29","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003793","name":"Swedish Heart and Lung Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Odd Fellow Order in Sweden"},{"name":"Samariten Foundation"},{"DOI":"10.13039\/100010342","name":"Gillbergska Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010342","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pediatric Research Foundation at Astrid Lindgren Children\u2019s Hospital"},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Heart Lung Foundation, Stockholm County"},{"DOI":"10.13039\/501100005416","name":"Norwegian Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007949","name":"Swedish Rheumatism Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007949","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut and Alice Wallenberg Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007857","name":"King Gustaf the V:th 80-year foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Congenital heart defects (CHD) aggregate in families, but recurrence patterns across kinships and generations remain incompletely understood. In light of improved survival and diagnostic precision, updated population-based estimates are needed. This study aimed to investigate familial recurrence patterns of CHD among relatives using nationwide Swedish register data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective, population-based case-control study was conducted, including 51 778 individuals with CHD born between 1987 and 2017 and 522 543 matched controls. Relatives (parents, full siblings, half-siblings, and offspring) were identified through linkage to national health and population registers. Logistic regression with robust standard errors clustered on maternal ID was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Dose\u2013response relationships, kinship-specific associations, and interactions with maternal comorbidities (diabetes, hypertension, and obesity) were explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among individuals with at least one affected relative, the OR for CHD was 2.71 (95% CI 2.60\u20132.83), increasing with each additional affected relative (OR per relative 2.55; 95% CI 2.46\u20132.64). Recurrence was strongest for mothers (OR 3.12), full siblings (OR 3.22), and offspring (OR 3.18) and lower for fathers and half-siblings. A dose\u2013response was observed by number of affected siblings and offspring. The association between maternal CHD and CHD in index individuals was not explained by maternal comorbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Congenital heart defect in a relative (parent, full or half-siblings, or offspring) is associated with CHD in the index individual, with recurrence patterns varying by kinship and number of affected relatives. These findings may inform genetic counselling and reproductive planning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehaf1048","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T12:38:45Z","timestamp":1765197525000},"page":"3905-3916","source":"Crossref","is-referenced-by-count":2,"title":["Congenital heart defects: familial recurrence patterns in Sweden"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4329-3451","authenticated-orcid":false,"given":"Kalliopi","family":"Kazamia","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology, Stockholm-Uppsala, Karolinska University Hospital , Eugeniav\u00e4gen 23, C8:34, Solna, Stockholm ,","place":["Sweden"]},{"name":"Department of Women\u2019s and Children\u2019s Health, Karolinska Institutet , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Ekberg","sequence":"additional","affiliation":[{"name":"Red Door Analytics AB , Stockholm \u00a0","place":["Sweden"]},{"name":"Department of Medicine Solna, Clinical Epidemiology Division, Karolinska Institutet , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8231-8183","authenticated-orcid":false,"given":"Caroline E","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Department of Medicine Solna, Clinical Epidemiology Division, Karolinska Institutet , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1565-8385","authenticated-orcid":false,"given":"H\u00e5kan","family":"Eliasson","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Stockholm-Uppsala, Karolinska University Hospital , Eugeniav\u00e4gen 23, C8:34, Solna, Stockholm ,","place":["Sweden"]},{"name":"Department of Women\u2019s and Children\u2019s Health, Karolinska Institutet , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0915-7245","authenticated-orcid":false,"given":"Marie","family":"Wahren-Herlenius","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Karolinska Institutet , Stockholm ,","place":["Sweden"]},{"name":"Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen , Bergen ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Bergman","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Stockholm-Uppsala, Karolinska University Hospital , Eugeniav\u00e4gen 23, C8:34, Solna, Stockholm ,","place":["Sweden"]},{"name":"Department of Women\u2019s and Children\u2019s Health, Karolinska Institutet , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"2026080219572227200_ehaf1048-B1","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1093\/ije\/dyz009","article-title":"Global birth prevalence of congenital heart defects 1970\u20132017: updated systematic review and meta-analysis of 260 studies","volume":"48","author":"Liu","year":"2019","journal-title":"Int J Epidemiol"},{"key":"2026080219572227200_ehaf1048-B2","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.1016\/j.jacc.2011.08.025","article-title":"Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis","volume":"58","author":"van der Linde","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"2026080219572227200_ehaf1048-B3","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/j.ahj.2014.07.030","article-title":"Birth prevalence of congenital heart defects in Norway 1994\u20132009\u2013a nationwide study","volume":"168","author":"Leirgul","year":"2014","journal-title":"Am Heart J"},{"key":"2026080219572227200_ehaf1048-B4","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1093\/eurjpc\/zwac227","article-title":"Congenital heart disease: changes in recorded birth prevalence and cardiac interventions over the past half-century in Sweden","volume":"30","author":"Giang","year":"2023","journal-title":"Eur J Prev Cardiol"},{"key":"2026080219572227200_ehaf1048-B5","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1017\/s1047951100012518","article-title":"The spectrum of fetal cardiac malformations","volume":"11","author":"Cook","year":"2001","journal-title":"Cardiol Young"},{"key":"2026080219572227200_ehaf1048-B6","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1161\/CIRCULATIONAHA.122.060834","article-title":"Adults with congenital heart disease: trends in event-free survival past middle age","volume":"147","author":"Dellborg","year":"2023","journal-title":"Circulation"},{"key":"2026080219572227200_ehaf1048-B7","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1186\/s12884-024-06529-5","article-title":"Maternal cardiovascular health in early pregnancy and the risk of congenital heart defects in offspring","volume":"24","author":"Zhang","year":"2024","journal-title":"BMC Pregnancy Childbirth"},{"key":"2026080219572227200_ehaf1048-B8","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s43042-020-0050-1","article-title":"Congenital heart diseases: genetics, non-inherited risk factors, and signaling pathways","volume":"21","author":"Suluba","year":"2020","journal-title":"Egypt J Med Hum Genet"},{"key":"2026080219572227200_ehaf1048-B9","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.3390\/genes12071020","article-title":"Molecular genetics and complex inheritance of congenital heart disease","volume":"12","author":"Diab","year":"2021","journal-title":"Genes (Basel)"},{"key":"2026080219572227200_ehaf1048-B10","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1161\/circresaha.116.309140","article-title":"Genetics and genomics of congenital heart disease","volume":"120","author":"Zaidi","year":"2017","journal-title":"Circ Res"},{"key":"2026080219572227200_ehaf1048-B11","doi-asserted-by":"publisher","first-page":"e011541","DOI":"10.1161\/jaha.119.011541","article-title":"Maternal obesity and diabetes mellitus as risk factors for congenital heart disease in the offspring","volume":"9","author":"Helle","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"2026080219572227200_ehaf1048-B12","doi-asserted-by":"publisher","first-page":"e0252343","DOI":"10.1371\/journal.pone.0252343","article-title":"Maternal obesity and metabolic disorders associate with congenital heart defects in the offspring: a systematic review","volume":"16","author":"Hedermann","year":"2021","journal-title":"PLoS One"},{"key":"2026080219572227200_ehaf1048-B13","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1007\/s00246-015-1182-9","article-title":"Maternal hypertension during pregnancy and the risk of congenital heart defects in offspring: a systematic review and meta-analysis","volume":"36","author":"Ramakrishnan","year":"2015","journal-title":"Pediatr Cardiol"},{"key":"2026080219572227200_ehaf1048-B14","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1161\/CIRCULATIONAHA.112.001054","article-title":"Association between maternal chronic conditions and congenital heart defects: a population-based cohort study","volume":"128","author":"Liu","year":"2013","journal-title":"Circulation"},{"key":"2026080219572227200_ehaf1048-B15","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.1161\/circulationaha.115.017465","article-title":"Prepregnancy diabetes and offspring risk of congenital heart disease: a nationwide cohort study","volume":"133","author":"\u00d8yen","year":"2016","journal-title":"Circulation"},{"key":"2026080219572227200_ehaf1048-B16","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1161\/circgenetics.109.890103","article-title":"Recurrence of discordant congenital heart defects in families","volume":"3","author":"Oyen","year":"2010","journal-title":"Circ Cardiovasc Genet"},{"key":"2026080219572227200_ehaf1048-B17","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1161\/circulationaha.109.857987","article-title":"Recurrence of congenital heart defects in families","volume":"120","author":"\u00d8yen","year":"2009","journal-title":"Circulation"},{"key":"2026080219572227200_ehaf1048-B18","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1002\/ajmg.a.38237","article-title":"Recurrence of congenital heart defects among siblings\u2014a nationwide study","volume":"173","author":"Brodwall","year":"2017","journal-title":"Am J Med Genet A"},{"key":"2026080219572227200_ehaf1048-B19","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1002\/ajmg.a.36500","article-title":"Risk of congenital heart disease in relatives of probands with conotruncal cardiac defects: an evaluation of 1,620 families","volume":"164A","author":"Peyvandi","year":"2014","journal-title":"Am J Med Genet A"},{"key":"2026080219572227200_ehaf1048-B20","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1253\/circj.cj-17-0250","article-title":"Familial aggregation and heritability of congenital heart defects","volume":"82","author":"Kuo","year":"2018","journal-title":"Circ J"},{"key":"2026080219572227200_ehaf1048-B21","doi-asserted-by":"publisher","first-page":"e017704","DOI":"10.1161\/JAHA.120.017704","article-title":"Survival in children with congenital heart disease: have we reached a peak at 97%?","volume":"9","author":"Mandalenakis","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"2026080219572227200_ehaf1048-B22","doi-asserted-by":"publisher","first-page":"e003868","DOI":"10.1161\/CIRCGEN.122.003868","article-title":"Familial aggregation studies: a valuable tool in the genetic toolbox","volume":"15","author":"Goldmuntz","year":"2022","journal-title":"Circ Genom Precis Med"},{"key":"2026080219572227200_ehaf1048-B23","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s10654-016-0117-y","article-title":"Registers of the Swedish total population and their use in medical research","volume":"31","author":"Ludvigsson","year":"2016","journal-title":"Eur J Epidemiol"},{"key":"2026080219572227200_ehaf1048-B24","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1186\/1471-2458-11-450","article-title":"External review and validation of the Swedish national inpatient register","volume":"11","author":"Ludvigsson","year":"2011","journal-title":"BMC Public Health"},{"key":"2026080219572227200_ehaf1048-B25","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s10654-022-00947-5","article-title":"The Swedish medical birth register during five decades: documentation of the content and quality of the register","volume":"38","author":"Cnattingius","year":"2023","journal-title":"Eur J Epidemiol"},{"key":"2026080219572227200_ehaf1048-B26","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1007\/s10654-017-0316-1","article-title":"The Swedish cause of death register","volume":"32","author":"Brooke","year":"2017","journal-title":"Eur J Epidemiol"},{"key":"2026080219572227200_ehaf1048-B27","author":"EUROCAT"},{"key":"2026080219572227200_ehaf1048-B28","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s10654-017-0325-0","article-title":"Case-control matching: effects, misconceptions, and recommendations","volume":"33","author":"Mansournia","year":"2018","journal-title":"Eur J Epidemiol"},{"key":"2026080219572227200_ehaf1048-B29","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1136\/bmj.332.7549.1080","article-title":"The cost of dichotomising continuous variables","volume":"332","author":"Altman","year":"2006","journal-title":"BMJ"},{"key":"2026080219572227200_ehaf1048-B30","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1093\/ije\/dyr218","article-title":"Recommendations for presenting analyses of effect modification and interaction","volume":"41","author":"Knol","year":"2012","journal-title":"Int J Epidemiol"},{"key":"2026080219572227200_ehaf1048-B31","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1002\/ajmg.a.20366","article-title":"Prevalence of congenital cardiovascular malformations among relatives of infants with hypoplastic left heart, coarctation of the aorta, and d-transposition of the great arteries","volume":"124A","author":"Loffredo","year":"2004","journal-title":"Am J Med Genet A"},{"key":"2026080219572227200_ehaf1048-B32","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1002\/gepi.1370110204","article-title":"Recurrence risk for major congenital heart defects in Sweden: a registry study","volume":"11","author":"Pradat","year":"1994","journal-title":"Genet Epidemiol"},{"key":"2026080219572227200_ehaf1048-B33","doi-asserted-by":"publisher","first-page":"e653","DOI":"10.1161\/CIR.0000000000000606","article-title":"Genetic basis for congenital heart disease: revisited: a scientific statement from the American Heart Association","volume":"138","author":"Pierpont","year":"2018","journal-title":"Circulation"},{"key":"2026080219572227200_ehaf1048-B34","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1093\/eurheartj\/ehx404","article-title":"A family of diseases in families of patients","volume":"39","author":"Schunkert","year":"2017","journal-title":"Eur Heart J"},{"key":"2026080219572227200_ehaf1048-B35","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1038\/ng.3970","article-title":"Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands","volume":"49","author":"Jin","year":"2017","journal-title":"Nat Genet"},{"key":"2026080219572227200_ehaf1048-B36","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1093\/eurheartj\/ehx314","article-title":"Familial co-occurrence of congenital heart defects follows distinct patterns","volume":"39","author":"Elles\u00f8e","year":"2018","journal-title":"Eur Heart J"},{"key":"2026080219572227200_ehaf1048-B37","doi-asserted-by":"publisher","first-page":"e003533","DOI":"10.1161\/circgen.121.003533","article-title":"Risk of congenital heart defects in offspring of affected mothers and fathers","volume":"15","author":"\u00d8yen","year":"2022","journal-title":"Circ Genom Precis Med"},{"key":"2026080219572227200_ehaf1048-B38","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/0002-9149(87)90956-8","article-title":"Maternal transmission of congenital heart diseases: new recurrence risk figures and the questions of cytoplasmic inheritance and vulnerability to teratogens","volume":"59","author":"Nora","year":"1987","journal-title":"Am J Cardiol"},{"key":"2026080219572227200_ehaf1048-B39","doi-asserted-by":"publisher","first-page":"695","DOI":"10.3892\/mmr.2013.1847","article-title":"Influence of genes and the environment in familial congenital heart defects","volume":"9","author":"Wang","year":"2013","journal-title":"Mol Med Rep"},{"key":"2026080219572227200_ehaf1048-B40","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1034\/j.1399-0004.2001.590505.x","article-title":"The risk for congenital heart defects in offspring of individuals with congenital heart defects","volume":"59","author":"Romano-Zelekha","year":"2001","journal-title":"Clin Genet"},{"key":"2026080219572227200_ehaf1048-B41","doi-asserted-by":"publisher","first-page":"a037234","DOI":"10.1101\/cshperspect.a037234","article-title":"Environmental risk factors for congenital heart disease","volume":"12","author":"Kalisch-Smith","year":"2019","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2026080219572227200_ehaf1048-B42","doi-asserted-by":"publisher","first-page":"e0234357","DOI":"10.1371\/journal.pone.0234357","article-title":"Gene-based analyses of the maternal genome implicate maternal effect genes as risk factors for conotruncal heart defects","volume":"15","author":"Sewda","year":"2020","journal-title":"PLoS One"},{"key":"2026080219572227200_ehaf1048-B43","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.17179\/excli2022-5298","article-title":"Mitochondrial mutations in protein coding genes of respiratory chain including complexes IV, V, and mt-tRNA genes are associated risk factors for congenital heart disease","volume":"21","author":"Heidari","year":"2022","journal-title":"EXCLI J"},{"key":"2026080219572227200_ehaf1048-B44","doi-asserted-by":"publisher","first-page":"e16506","DOI":"10.1371\/journal.pone.0016506","article-title":"Maternal genome-wide DNA methylation patterns and congenital heart defects","volume":"6","author":"Chowdhury","year":"2011","journal-title":"PLoS One"},{"key":"2026080219572227200_ehaf1048-B45","doi-asserted-by":"publisher","first-page":"nzaa166","DOI":"10.1093\/cdn\/nzaa166","article-title":"Exploring the role of maternal nutritional epigenetics in congenital heart disease","volume":"4","author":"Joshi","year":"2020","journal-title":"Curr Dev Nutr"},{"key":"2026080219572227200_ehaf1048-B46","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/joim.13351","article-title":"The frequency of misattributed paternity in Sweden is low and decreasing: a nationwide cohort study","volume":"291","author":"Dahl\u00e9n","year":"2022","journal-title":"J Intern Med"},{"key":"2026080219572227200_ehaf1048-B47","doi-asserted-by":"publisher","first-page":"e95085","DOI":"10.1172\/jci.insight.95085","article-title":"Epigenetic mechanisms underlying maternal diabetes-associated risk of congenital heart disease","volume":"2","author":"Basu","year":"2017","journal-title":"JCI Insight"},{"key":"2026080219572227200_ehaf1048-B48","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1177\/2150135115615786","article-title":"How suitable are registry data for recurrence risk calculations? Validation of diagnoses on 1,593 families with congenital heart disease","volume":"7","author":"Elles\u00f8e","year":"2016","journal-title":"World J Pediatr Congenit Heart Surg"}],"container-title":["European Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/47\/29\/3905\/66307261\/ehaf1048.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/47\/29\/3905\/66307261\/ehaf1048.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T23:57:30Z","timestamp":1785715050000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurheartj\/article\/47\/29\/3905\/8417266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,8]]},"references-count":48,"journal-issue":{"issue":"29","published-online":{"date-parts":[[2026,1,8]]},"published-print":{"date-parts":[[2026,8,3]]}},"URL":"https:\/\/doi.org\/10.1093\/eurheartj\/ehaf1048","relation":{},"ISSN":["0195-668X","1522-9645"],"issn-type":[{"value":"0195-668X","type":"print"},{"value":"1522-9645","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,8,1]]},"published":{"date-parts":[[2026,1,8]]}}}