{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:29:53Z","timestamp":1790728193177,"version":"4.1.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"13","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370330"],"award-info":[{"award-number":["82370330"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100325"],"award-info":[{"award-number":["82100325"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000325"],"award-info":[{"award-number":["82000325"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070349"],"award-info":[{"award-number":["82070349"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["Z240022"],"award-info":[{"award-number":["Z240022"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"publisher","award":["20250484856"],"award-info":[{"award-number":["20250484856"]}],"id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2023YFC2412705"],"award-info":[{"award-number":["2023YFC2412705"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Post-doctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M772047"],"award-info":[{"award-number":["2025M772047"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Post-doctoral Science Foundation","doi-asserted-by":"publisher","award":["GZC20251339"],"award-info":[{"award-number":["GZC20251339"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Innovation Fund for Medical Sciences","award":["2021-I2M-C&T-B-028"],"award-info":[{"award-number":["2021-I2M-C&T-B-028"]}]},{"name":"Innovation Fund for Medical Sciences","award":["2024-I2M-C&T-B-038"],"award-info":[{"award-number":["2024-I2M-C&T-B-038"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2025-XHQN07"],"award-info":[{"award-number":["2025-XHQN07"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Beijing Gold-bridge project","award":["ZZ21055"],"award-info":[{"award-number":["ZZ21055"]}]},{"name":"Young Elite Scientists Sponsorship Program by Beijing Association for Science and Technology","award":["BYESS2023392"],"award-info":[{"award-number":["BYESS2023392"]}]},{"name":"Peking University First Hospital Seed Foundation","award":["2020SF19"],"award-info":[{"award-number":["2020SF19"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2022-GSP-GG-11"],"award-info":[{"award-number":["2022-GSP-GG-11"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2023-GSP-GG-22"],"award-info":[{"award-number":["2023-GSP-GG-22"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2023-GSP-QN-40"],"award-info":[{"award-number":["2023-GSP-QN-40"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Left bundle branch pacing (LBBP) for cardiac resynchronization therapy is emerging as an alternative pacing strategy to biventricular pacing (BiVP) in dyssynchronous heart failure (DHF). This study aimed to explore the differences in treatment effects between the two pacing modalities using electrocardiographic, echocardiographic, and molecular measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult canines underwent left bundle branch ablation, then either followed by 6 weeks of atrial tachypacing (DHF group, n = 8), or 3 weeks of atrial tachypacing followed by another 3 weeks of BiVP (n = 8) or LBBP (n = 8) tachypacing. Non-intervened canines constituted the control group (n = 7). Electrocardiographic, echocardiographic, and molecular features were compared between BiVP-treated and LBBP-treated DHF canines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>BiVP- and LBBP-treated canines achieved equivalent reduction in QRS duration (32 \u00b1 6\u2005ms vs 35 \u00b1 5\u2005ms, P = .276). Both BiVP and LBBP increased left ventricular ejection fraction (9 \u00b1 5% and 10 \u00b1 4%, respectively; P = .390) while LBBP significantly outperformed BiVP in improving left ventricular global longitudinal strain (\u22123.7 \u00b1 1.2% vs \u22122.3 \u00b1 1.0%, P = .019). Both BiVP and LBBP reversed biomarkers of heart failure, while LBBP more significantly modulated cytoskeleton proteins, TGF-\u03b2 signalling pathways and SERCA2a expression. Moreover, LBBP contributed to a more comprehensive improvement in myocardial energy metabolism compared to BiVP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study in a DHF animal model indicates that LBBP results in electrocardiographic, echocardiographic, and molecular recovery at least as good as that during BiVP. The superiority of LBBP is especially reflected in more pronounced normalization of cardiac cytoskeleton, calcium handling and energy metabolism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehaf1093","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T12:32:37Z","timestamp":1766406757000},"page":"1595-1605","source":"Crossref","is-referenced-by-count":4,"title":["Left bundle branch vs biventricular pacing: mechanistic insights from a canine model"],"prefix":"10.1093","volume":"47","author":[{"given":"Hao","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Cardiology, The Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chines Academy of Medical Sciences and Peking Union Medical College , No.167 North Lishi Road, Beijing 100037 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chines Academy of Medical Sciences and Peking Union Medical College , No.167 North Lishi Road, Beijing 100037 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0837-0826","authenticated-orcid":false,"given":"Sijing","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chines Academy of Medical Sciences and Peking Union Medical College , No.167 North Lishi Road, Beijing 100037 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chines Academy of Medical Sciences and Peking Union Medical College , No.167 North Lishi Road, Beijing 100037 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2466-9046","authenticated-orcid":false,"given":"Sixian","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengkang","family":"He","sequence":"additional","affiliation":[{"name":"Cardiology Department, Peking University First Hospital , Beijing 100034 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juwei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chines Academy of Medical Sciences and Peking Union Medical College , No.167 North Lishi Road, Beijing 100037 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanzhi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chines Academy of Medical Sciences and Peking Union Medical College , No.167 North Lishi Road, Beijing 100037 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqiu","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6374-112X","authenticated-orcid":false,"given":"Liang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chines Academy of Medical Sciences and Peking Union Medical College , No.167 North Lishi Road, Beijing 100037 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5610-5974","authenticated-orcid":false,"given":"Ligang","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chines Academy of Medical Sciences and Peking Union Medical College , No.167 North Lishi Road, Beijing 100037 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3033-4741","authenticated-orcid":false,"given":"Hongxia","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chines Academy of Medical Sciences and Peking Union Medical College , No.167 North Lishi Road, Beijing 100037 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Jin","sequence":"additional","affiliation":[{"name":"Cardiology Department, Peking University First Hospital , Beijing 100034 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7090-4414","authenticated-orcid":false,"given":"Xiangbin","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Structural Heart Disease,State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing ,","place":["China"]},{"name":"Department of Structural Heart Disease, Fuwai Shenzhen Hospital, Chinese Academy of Medical Sciences, Shenzhen Medical Academy of Research and Translation (SMART) , Shenzhen 518107 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8818-5964","authenticated-orcid":false,"given":"Kevin","family":"Vernooy","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center , Maastricht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8917-9032","authenticated-orcid":false,"given":"Frits W","family":"Prinzen","sequence":"additional","affiliation":[{"name":"Department of Physiology, Cardiovascular Research Institute (CARIM), Maastricht University , Maastricht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6921-9375","authenticated-orcid":false,"given":"Wei","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chines Academy of Medical Sciences and Peking Union Medical College , No.167 North Lishi Road, Beijing 100037 ,","place":["China"]},{"name":"Department of Cardiology, Fuwai Shenzhen Hospital, Chinese Academy of Medical Sciences, Shenzhen Medical Academy of Research and Translation (SMART) , Shenzhen 518107 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"2026040118480252900_ehaf1093-B1","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1056\/NEJMoa050496","article-title":"The effect of cardiac resynchronization on morbidity and mortality in heart failure","volume":"352","author":"Cleland","year":"2005","journal-title":"N Engl J Med"},{"key":"2026040118480252900_ehaf1093-B2","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1056\/NEJMoa0906431","article-title":"Cardiac-resynchronization therapy for the prevention of heart-failure events","volume":"361","author":"Moss","year":"2009","journal-title":"N Engl J Med"},{"key":"2026040118480252900_ehaf1093-B3","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.1056\/NEJMoa1401426","article-title":"Survival with cardiac-resynchronization therapy in mild heart failure","volume":"370","author":"Goldenberg","year":"2014","journal-title":"N Engl J Med"},{"key":"2026040118480252900_ehaf1093-B4","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1016\/j.jacc.2012.10.053","article-title":"Resolution of left bundle branch block-induced cardiomyopathy by cardiac resynchronization therapy","volume":"61","author":"Vaillant","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"2026040118480252900_ehaf1093-B5","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nrcardio.2014.67","article-title":"Strategies to improve cardiac resynchronization therapy","volume":"11","author":"Vernooy","year":"2014","journal-title":"Nat Rev Cardiol"},{"key":"2026040118480252900_ehaf1093-B6","doi-asserted-by":"publisher","first-page":"H2238","DOI":"10.1152\/ajpheart.00684.2001","article-title":"Left ventricular resynchronization therapy in a canine model of left bundle branch block","volume":"282","author":"Liu","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026040118480252900_ehaf1093-B7","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1161\/01.CIR.0000088782.99568.CA","article-title":"Regional alterations in protein expression in the dyssynchronous failing heart","volume":"108","author":"Spragg","year":"2003","journal-title":"Circulation"},{"key":"2026040118480252900_ehaf1093-B8","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.1093\/eurheartj\/ehm207","article-title":"Cardiac resynchronization therapy cures dyssynchronopathy in canine left bundle-branch block hearts","volume":"28","author":"Vernooy","year":"2007","journal-title":"Eur Heart J"},{"key":"2026040118480252900_ehaf1093-B9","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1161\/CIRCULATIONAHA.108.794834","article-title":"Electrophysiological consequences of dyssynchronous heart failure and its restoration by resynchronization therapy","volume":"119","author":"Aiba","year":"2009","journal-title":"Circulation"},{"key":"2026040118480252900_ehaf1093-B10","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1161\/CIRCULATIONAHA.108.774752","article-title":"Mechanisms of enhanced beta-adrenergic reserve from cardiac resynchronization therapy","volume":"119","author":"Chakir","year":"2009","journal-title":"Circulation"},{"key":"2026040118480252900_ehaf1093-B11","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.yjmcc.2014.03.012","article-title":"Remodeling of the sarcomeric cytoskeleton in cardiac ventricular myocytes during heart failure and after cardiac resynchronization therapy","volume":"72","author":"Lichter","year":"2014","journal-title":"J Mol Cell Cardiol"},{"key":"2026040118480252900_ehaf1093-B12","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1161\/CIRCRESAHA.116.305268","article-title":"Cardiac resynchronization therapy restores sympathovagal balance in the failing heart by differential remodeling of cholinergic signaling","volume":"116","author":"DeMazumder","year":"2015","journal-title":"Circ Res"},{"key":"2026040118480252900_ehaf1093-B13","doi-asserted-by":"publisher","first-page":"1736.e1","DOI":"10.1016\/j.cjca.2017.09.013","article-title":"A novel pacing strategy with low and stable output: pacing the left bundle branch immediately beyond the conduction block","volume":"33","author":"Huang","year":"2017","journal-title":"Can J Cardiol"},{"key":"2026040118480252900_ehaf1093-B14","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1093\/europace\/euab249","article-title":"Cardiac resynchronization therapy via left bundle branch pacing vs. optimized biventricular pacing with adaptive algorithm in heart failure with left bundle branch block: a prospective, multi-centre, observational study","volume":"24","author":"Chen","year":"2022","journal-title":"Europace"},{"key":"2026040118480252900_ehaf1093-B15","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1016\/j.jacc.2022.07.019","article-title":"Randomized trial of left bundle branch vs biventricular pacing for cardiac resynchronization therapy","volume":"80","author":"Wang","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"2026040118480252900_ehaf1093-B16","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1161\/CIRCULATIONAHA.107.706291","article-title":"Reversal of global apoptosis and regional stress kinase activation by cardiac resynchronization","volume":"117","author":"Chakir","year":"2008","journal-title":"Circulation"},{"key":"2026040118480252900_ehaf1093-B17","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1161\/CIRCGENETICS.108.832345","article-title":"Cardiac resynchronization therapy corrects dyssynchrony-induced regional gene expression changes on a genomic level","volume":"2","author":"Barth","year":"2009","journal-title":"Circ Cardiovasc Genet"},{"key":"2026040118480252900_ehaf1093-B18","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1111\/jce.15854","article-title":"A novel approach for developing left bundle branch pacing and left bundle branch block in a canine model","volume":"34","author":"Hu","year":"2023","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2026040118480252900_ehaf1093-B19","doi-asserted-by":"publisher","first-page":"947","DOI":"10.15212\/CVIA.2023.0066","article-title":"Left bundle branch ablation guided by a three-dimensional mapping system: a novel method for establishing a heart failure animal model","volume":"8","author":"He","year":"2023","journal-title":"Cardiovasc Innov Appl"},{"key":"2026040118480252900_ehaf1093-B20","doi-asserted-by":"publisher","first-page":"2234","DOI":"10.1016\/j.jacep.2024.05.007","article-title":"Left bundle branch area pacing with or without conduction system capture in heart failure models","volume":"10","author":"Cheng","year":"2024","journal-title":"JACC Clin Electrophysiol"},{"key":"2026040118480252900_ehaf1093-B21","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1161\/01.CIR.0000035037.11968.5C","article-title":"Systolic improvement and mechanical resynchronization does not require electrical synchrony in the dilated failing heart with left bundle-branch block","volume":"106","author":"Leclercq","year":"2002","journal-title":"Circulation"},{"key":"2026040118480252900_ehaf1093-B22","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1093\/europace\/euad043","article-title":"EHRA clinical consensus statement on conduction system pacing implantation: endorsed by the Asia Pacific Heart Rhythm Society (APHRS), Canadian Heart Rhythm Society (CHRS), and Latin American Heart Rhythm Society (LAHRS)","volume":"25","author":"Burri","year":"2023","journal-title":"Europace"},{"key":"2026040118480252900_ehaf1093-B23","doi-asserted-by":"publisher","first-page":"4161","DOI":"10.1093\/eurheartj\/ehac445","article-title":"Left bundle branch area pacing outcomes: the multicentre European MELOS study","volume":"43","author":"Jastrz\u0119bski","year":"2022","journal-title":"Eur Heart J"},{"key":"2026040118480252900_ehaf1093-B24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J Am Soc Echocardiogr"},{"key":"2026040118480252900_ehaf1093-B25","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"2026040118480252900_ehaf1093-B26","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1111\/jce.13171","article-title":"Effect of cardiac resynchronization therapy on myocardial fibrosis and relevant cytokines in a canine model with experimental heart failure","volume":"28","author":"Wang","year":"2017","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2026040118480252900_ehaf1093-B27","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1161\/CIRCGENETICS.113.000404","article-title":"Mechanical unloading promotes myocardial energy recovery in human heart failure","volume":"7","author":"Gupte","year":"2014","journal-title":"Circ Cardiovasc Genet"},{"key":"2026040118480252900_ehaf1093-B28","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.jacep.2023.10.016","article-title":"Left bundle branch pacing vs left ventricular septal pacing vs biventricular pacing for cardiac resynchronization therapy","volume":"10","author":"Diaz","year":"2024","journal-title":"JACC Clin Electrophysiol"},{"key":"2026040118480252900_ehaf1093-B29","doi-asserted-by":"publisher","first-page":"e011181","DOI":"10.1161\/CIRCEP.122.011181","article-title":"Left bundle branch pacing versus biventricular pacing for acute cardiac resynchronization in patients with heart failure","volume":"15","author":"Liang","year":"2022","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2026040118480252900_ehaf1093-B30","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.jacc.2023.05.006","article-title":"Comparison of left bundle branch area pacing and biventricular pacing in candidates for resynchronization therapy","volume":"82","author":"Vijayaraman","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"2026040118480252900_ehaf1093-B31","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1016\/j.jacep.2023.04.015","article-title":"Left bundle branch area pacing versus biventricular pacing as initial strategy for cardiac resynchronization","volume":"9","author":"Diaz","year":"2023","journal-title":"JACC Clin Electrophysiol"},{"key":"2026040118480252900_ehaf1093-B32","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/j.hrthm.2024.02.024","article-title":"Efficacy of left bundle branch area pacing versus biventricular pacing in patients treated with cardiac resynchronization therapy: select site\u2014cohort study","volume":"21","author":"Shroff","year":"2024","journal-title":"Heart Rhythm"},{"key":"2026040118480252900_ehaf1093-B33","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.jacc.2019.11.040","article-title":"Short-term hemodynamic and electrophysiological effects of cardiac resynchronization by left ventricular septal pacing","volume":"75","author":"Salden","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"2026040118480252900_ehaf1093-B34","doi-asserted-by":"publisher","first-page":"euaf034","DOI":"10.1093\/europace\/euaf034","article-title":"Time-dependent repolarization changes following left bundle branch area pacing vs. conventional biventricular pacing in patients with dyssynchronous heart failure","volume":"27","author":"Smits","year":"2025","journal-title":"Europace"},{"key":"2026040118480252900_ehaf1093-B35","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1016\/j.jacep.2024.04.022","article-title":"LVSP and LBBP result in similar or improved LV synchrony and hemodynamics compared to BVP","volume":"10","author":"Curila","year":"2024","journal-title":"JACC Clin Electrophysiol"},{"key":"2026040118480252900_ehaf1093-B36","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1016\/S0735-1097(03)00091-3","article-title":"Left ventricular septal and apex pacing for optimal pump function in canine hearts","volume":"41","author":"Peschar","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"2026040118480252900_ehaf1093-B37","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1016\/j.hrthm.2024.09.018","article-title":"Electrocardiographic predictors of clinical outcomes in nonischemic cardiomyopathy patients with left bundle branch area pacing cardiac resynchronization therapy","volume":"22","author":"Shroff","year":"2025","journal-title":"Heart Rhythm"},{"key":"2026040118480252900_ehaf1093-B38","doi-asserted-by":"publisher","first-page":"H372","DOI":"10.1152\/ajpheart.2002.282.1.H372","article-title":"Effects of single- and biventricular pacing on temporal and spatial dynamics of ventricular contraction","volume":"282","author":"Wyman","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026040118480252900_ehaf1093-B39","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1161\/CIRCEP.109.882910","article-title":"Left ventricular septal and left ventricular apical pacing chronically maintain cardiac contractile coordination, pump function and efficiency","volume":"2","author":"Mills","year":"2009","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2026040118480252900_ehaf1093-B40","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1093\/europace\/euy035","article-title":"Pathobiology of cardiac dyssynchrony and resynchronization therapy","volume":"20","author":"Nguy\u00ean","year":"2018","journal-title":"Europace"},{"key":"2026040118480252900_ehaf1093-B41","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.stem.2023.03.010","article-title":"Gene editing to prevent ventricular arrhythmias associated with cardiomyocyte cell therapy","volume":"30","author":"Marchiano","year":"2023","journal-title":"Cell Stem Cell"},{"key":"2026040118480252900_ehaf1093-B42","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s10741-019-09873-3","article-title":"SERCA2a: a key protein in the Ca2+ cycle of the heart failure","volume":"25","author":"Zhihao","year":"2020","journal-title":"Heart Fail Rev"},{"key":"2026040118480252900_ehaf1093-B43","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.3390\/ijms18071362","article-title":"Ankyrin repeat domain 1 protein: a functionally pleiotropic protein with cardiac biomarker potential","volume":"18","author":"Ling","year":"2017","journal-title":"Int J Mol Sci"},{"key":"2026040118480252900_ehaf1093-B44","doi-asserted-by":"publisher","first-page":"2128","DOI":"10.1093\/eurheartj\/ehp225","article-title":"Mutations in the ANKRD1 gene encoding CARP are responsible for human dilated cardiomyopathy","volume":"30","author":"Duboscq-Bidot","year":"2009","journal-title":"Eur Heart J"},{"key":"2026040118480252900_ehaf1093-B45","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1161\/01.RES.88.1.30","article-title":"Transforming growth factor-beta\/Smads signaling induces transcription of the cell type-restricted ankyrin repeat protein CARP gene through CAGA motif in vascular smooth muscle cells","volume":"88","author":"Kanai","year":"2001","journal-title":"Circ Res"},{"key":"2026040118480252900_ehaf1093-B46","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/S0008-6363(03)00511-X","article-title":"Arteriogenesis is associated with an induction of the cardiac ankyrin repeat protein (carp)","volume":"59","author":"Boengler","year":"2003","journal-title":"Cardiovasc Res"},{"key":"2026040118480252900_ehaf1093-B47","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1016\/j.ymthe.2024.03.018","article-title":"Nuclear AGO2 promotes myocardial remodeling by activating ANKRD1 transcription in failing hearts","volume":"32","author":"Xie","year":"2024","journal-title":"Mol Ther"},{"key":"2026040118480252900_ehaf1093-B48","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1161\/01.CIR.85.3.1125","article-title":"Regional myocardial perfusion and glucose metabolism in experimental left bundle branch block","volume":"85","author":"Ono","year":"1992","journal-title":"Circulation"},{"key":"2026040118480252900_ehaf1093-B49","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1161\/01.CIR.0000138108.68719.C1","article-title":"Effects of cardiac resynchronization therapy on myocardial perfusion reserve","volume":"110","author":"Knaapen","year":"2004","journal-title":"Circulation"},{"key":"2026040118480252900_ehaf1093-B50","doi-asserted-by":"publisher","first-page":"2850","DOI":"10.1016\/j.devcel.2024.07.015","article-title":"GLUD1 determines murine muscle stem cell fate by controlling mitochondrial glutamate levels","volume":"59","author":"Soro-Arn\u00e1iz","year":"2024","journal-title":"Dev Cell"},{"key":"2026040118480252900_ehaf1093-B51","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/nrm2764","article-title":"Protein denitrosylation: enzymatic mechanisms and cellular functions","volume":"10","author":"Benhar","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026040118480252900_ehaf1093-B52","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1161\/CIRCRESAHA.115.307157","article-title":"S-Nitrosylation of calcium-handling proteins in cardiac adrenergic signaling and hypertrophy","volume":"117","author":"Irie","year":"2015","journal-title":"Circ Res"},{"key":"2026040118480252900_ehaf1093-B53","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1161\/CIRCRESAHA.118.313956","article-title":"S-Nitrosoglutathione reductase is essential for protecting the female heart from ischemia-reperfusion injury","volume":"123","author":"Casin","year":"2018","journal-title":"Circ Res"},{"key":"2026040118480252900_ehaf1093-B54","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1161\/CIRCULATIONAHA.119.042336","article-title":"SNO-MLP (S-Nitrosylation of muscle LIM protein) facilitates myocardial hypertrophy through TLR3 (toll-like receptor 3)-mediated RIP3 (receptor-interacting protein kinase 3) and NLRP3 (NOD-like receptor pyrin domain containing 3) inflammasome activation","volume":"141","author":"Tang","year":"2020","journal-title":"Circulation"},{"key":"2026040118480252900_ehaf1093-B55","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1161\/CIRCRESAHA.123.322654","article-title":"Mitochondrial GSNOR alleviates cardiac dysfunction via ANT1 denitrosylation","volume":"133","author":"Tang","year":"2023","journal-title":"Circ Res"},{"key":"2026040118480252900_ehaf1093-B56","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euaf050","article-title":"European Society of Cardiology (ESC) clinical consensus statement on indications for conduction system pacing, with special contribution of the European Heart Rhythm Association of the ESC and endorsed by the Asia Pacific Heart Rhythm Society, the Canadian Heart Rhythm Society, the Heart Rhythm Society, and the Latin American Heart Rhythm Society","volume":"27","author":"Glikson","year":"2025","journal-title":"Europace"}],"container-title":["European Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/47\/13\/1595\/66394987\/ehaf1093.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/47\/13\/1595\/66394987\/ehaf1093.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T22:48:09Z","timestamp":1775083689000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurheartj\/article\/47\/13\/1595\/8424140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,13]]},"references-count":56,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2026,1,13]]},"published-print":{"date-parts":[[2026,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/eurheartj\/ehaf1093","relation":{},"ISSN":["0195-668X","1522-9645"],"issn-type":[{"value":"0195-668X","type":"print"},{"value":"1522-9645","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,4,1]]},"published":{"date-parts":[[2026,1,13]]}}}