{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T04:27:57Z","timestamp":1794112077232,"version":"4.8.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"26","license":[{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Randomized trials of colchicine in secondary prevention of atherosclerotic cardiovascular disease have shown mixed results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review and study-level meta-analysis of randomized controlled trials was performed comparing colchicine vs no colchicine in a secondary-prevention atherosclerotic cardiovascular disease population. A fixed-effect inverse variance model was applied using the intention-to-treat population from the included trials. The primary outcome was the composite of cardiovascular death, myocardial infarction, or stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nine trials, including 30 659 patients (colchicine 15 255, no colchicine 15 404) with known coronary artery disease or stroke, were included. Compared with no colchicine, patients randomized to colchicine had a relative risk (RR) of 0.88 [95% confidence interval (CI) 0.81\u20130.95, P = .002] for the primary composite outcome, including a RR of 0.94 for cardiovascular death (95% CI 0.78\u20131.13, P = .5), a RR of 0.84 for myocardial infarction (95% CI 0.73\u20130.97, P = .016), and a RR of 0.90 for stroke (95% CI 0.80\u20131.02, P = .09). Colchicine was associated with a RR of 1.35 for hospitalization for gastrointestinal events (95% CI 1.10\u20131.66, P = .004) with no increase in hospitalization for pneumonia, newly diagnosed cancers, or non-cardiovascular death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with prior coronary disease or stroke, colchicine reduced the composite of cardiovascular death, myocardial infarction, or stroke by 12%.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehaf210","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:19:58Z","timestamp":1742257198000},"page":"2564-2575","source":"Crossref","is-referenced-by-count":71,"title":["Colchicine for secondary prevention of vascular events: a meta-analysis of trials"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1432-7384","authenticated-orcid":false,"given":"Marc-Andr\u00e9","family":"d\u2019Entremont","sequence":"first","affiliation":[{"name":"Population Health Research Institute , 237 Barton Street East, Hamilton L8L 2X2, Ontario ,","place":["Canada"]},{"name":"Department of Cardiology, Hamilton General Hospital, McMaster University , 237 Barton Street East, Hamilton L8L 2X2, Ontario ,","place":["Canada"]},{"name":"D\u00e9partement de M\u00e9decine, Centre Hospitalier Universitaire de Sherbrooke , Sherbrooke, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel H F","family":"Poorthuis","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Medical Center Utrecht , Utrecht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aernoud T L","family":"Fiolet","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Utrecht , Utrecht ,","place":["The Netherlands"]},{"name":"Dutch Network for Cardiovascular Research (WCN) , Utrecht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Amarenco","sequence":"additional","affiliation":[{"name":"Population Health Research Institute , 237 Barton Street East, Hamilton L8L 2X2, Ontario ,","place":["Canada"]},{"name":"Department of Neurology, Bichat University Hospital , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin Emery","family":"Boczar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Ottawa Heart Institute , Ottawa, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Buysschaert","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sint-Jan Hospital , Brugge ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9491-6172","authenticated-orcid":false,"given":"Noel C","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Haematology and Thromboembolism, McMaster University , Hamilton, ON ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan H","family":"Cornel","sequence":"additional","affiliation":[{"name":"Dutch Network for Cardiovascular Research (WCN) , Utrecht ,","place":["The Netherlands"]},{"name":"Department of Cardiology, Northwest Clinics , Alkmaar ,","place":["The Netherlands"]},{"name":"Department of Cardiology, Radboud University Medical Centre , Nijmegen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jalina","family":"Jannink","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Meander Medical Center , Amersfoort ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley","family":"Jansen","sequence":"additional","affiliation":[{"name":"Heart and Vascular Research Institute, Harry Perkins Institute for Medical Research , Perth ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasko","family":"Kedev","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Ss. Cyril and Methodius , Skopje ,","place":["North Macedonia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony C","family":"Keech","sequence":"additional","affiliation":[{"name":"NHMRC Clinical Trials Centre, Faculty of Medicine and Health, University of Sydney , Sydney ,","place":["Australia"]},{"name":"Department of Cardiology, Royal Prince Alfred Hospital , Sydney ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Layland","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Peninsula Health, Peninsula Clinical School, Central Clinical School, Monash University , Frankston, VIC ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Mewton","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Institut de Cardiologie des Hospices Civils de Lyon , Lyon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Montalescot","sequence":"additional","affiliation":[{"name":"Sorbonne University, ACTION Study Group, Centre Hospitalier Universitaire Piti\u00e9\u2013Salp\u00eatri\u00e8re Assistance Publique\u2013Hopitaux de Paris , Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domingo A","family":"Pascual-Figal","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Virgen de la Arrixaca, University of Murcia , Murcia ,","place":["Spain"]},{"name":"Department of Cardiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC) , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo E","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Otamendi Hospital , Buenas Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binita","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Cardiology, VA New York Harbor Healthcare System , New York, New York ,","place":["USA"]},{"name":"Leon H Charney Division of Cardiology, NYU Grossman School of Medicine , New York, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6751-6752","authenticated-orcid":false,"given":"Martin","family":"Teraa","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, University Medical Center Utrecht , Utrecht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimee","family":"van Zelm","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, University Medical Center Utrecht , Utrecht ,","place":["The 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