{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T13:40:06Z","timestamp":1794490806087,"version":"4.9.1"},"reference-count":128,"publisher":"Oxford University Press (OUP)","issue":"26","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acute right ventricular failure is a complex and rapidly progressive clinical syndrome, whereby the right ventricle fails to provide adequate left ventricular preload, dilates, and causes systemic venous congestion. Previous research in acute heart failure has primarily focused on the left ventricle. Yet, the need for a better understanding of right ventricular anatomy, physiology, and pathophysiology, as well as of the diagnosis and management of its acute failure is crucial. Diagnosis mandates a high degree of clinical suspicion, as the majority of signs and symptoms are nonspecific. An accurate and prompt identification of the underlying causes, including pulmonary embolism, right ventricular myocardial infarction, acute respiratory distress syndrome, post-cardiac surgery, and decompensated chronic pulmonary hypertension, is therefore essential. This review provides insights into right ventricular anatomy and functioning and discusses the pathophysiology of acute right ventricular failure, its differential aetiologies, clinical presentation, diagnosis, and treatment.<\/jats:p>","DOI":"10.1093\/eurheartj\/ehaf215","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T16:19:41Z","timestamp":1742314781000},"page":"2520-2535","source":"Crossref","is-referenced-by-count":51,"title":["Acute right ventricular failure: pathophysiology, aetiology, assessment, and management"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7491-6319","authenticated-orcid":false,"given":"George","family":"Giannakoulas","sequence":"first","affiliation":[{"name":"Department of Cardiology, AHEPA University Hospital, Aristotle University of Thessaloniki , Kiriakidi 1, Thessaloniki 54636 ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0586-6386","authenticated-orcid":false,"given":"Ioannis T","family":"Farmakis","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I, LMU Klinikum , Munich ,","place":["Germany"]},{"name":"Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University , Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4312-0366","authenticated-orcid":false,"given":"Lukas","family":"Hobohm","sequence":"additional","affiliation":[{"name":"Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University , Mainz ,","place":["Germany"]},{"name":"Department of Cardiology, University Medical Center of the Johannes Gutenberg University , Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik H","family":"Verbrugge","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Diseases, University Hospital Brussels , Jette ,","place":["Belgium"]},{"name":"Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel , Brussels ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan J","family":"Tedford","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Medical University of South Carolina , Charleston, SC ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Sanz","sequence":"additional","affiliation":[{"name":"Mount Sinai Heart, Icahn School of Medicine at Mount Sinai Health System , New York, NY ,","place":["USA"]},{"name":"Centro Integral de Enfermedades Cardiovasculares (CIEC), Hospital Universitario HM Montepr\u00edncipe , Madrid ,","place":["Spain"]},{"name":"Atriaclinic , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"key":"2025070712264737900_ehaf215-B1","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1016\/j.jacc.2018.12.076","article-title":"Anatomy, function, and dysfunction of the right ventricle: JACC state-of-the-art review","volume":"73","author":"Sanz","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2025070712264737900_ehaf215-B2","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/0146-2806(91)90009-y","article-title":"The right ventricle: anatomy, physiology, and clinical importance","volume":"16","author":"Dell'Italia","year":"1991","journal-title":"Curr Probl Cardiol"},{"key":"2025070712264737900_ehaf215-B3","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1161\/CIRCULATIONAHA.107.653576","article-title":"Right ventricular function in cardiovascular disease, part I: anatomy, physiology, aging, and functional assessment of the right ventricle","volume":"117","author":"Haddad","year":"2008","journal-title":"Circulation"},{"key":"2025070712264737900_ehaf215-B4","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/s0033-0620(98)80049-2","article-title":"Ventricular interdependence: significant left ventricular contributions to right ventricular systolic function","volume":"40","author":"Santamore","year":"1998","journal-title":"Prog Cardiovasc Dis"},{"key":"2025070712264737900_ehaf215-B5","doi-asserted-by":"publisher","first-page":"e15","DOI":"10.1164\/rccm.201806-1160ST","article-title":"Assessment of right ventricular function in the research setting: knowledge gaps and pathways forward. 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