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The objective of this study was to validate a multimarker prognostic calculator and compare its performance with that of the European Society of Cardiology (ESC) model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The multimarker calculator estimates absolute risk of key outcomes for an individual patient based on the individual variables of the simplified Pulmonary Embolism Severity Index, natriuretic peptide levels, troponin levels, and concomitant lower limb deep vein thrombosis. Using data for haemodynamically stable patients with acute PE from the Registro Informatizado de la Enfermedad TromboEmb\u00f3lica registry, the study compared the performance of the multimarker calculator and the ESC model using measures of discrimination and calibration. The primary outcome was 30-day all-cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 60 042 stable patients with PE (mean age: 67 years, 51.8% female) were included. Compared with the ESC model, the multimarker calculator provided significant C-statistic improvement in the whole cohort (0.79 vs. 0.56; P &amp;lt; .001), in the group of 16 648 participants with available data for right ventricular function\/size and troponin (0.78 vs. 0.66; P &amp;lt; .001), and after imputation of missing data (0.79 vs. 0.66; P &amp;lt; .001). At a calculator estimated risk of &amp;gt;10% to identify intermediate-high risk PE, the positive predictive value for mortality was 15.7% (vs. 5.0% for the ESC model; P &amp;lt; .001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In stable patients with acute PE, the use of a multimarker calculator substantially improved the risk stratification for mortality beyond that of the ESC model.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehaf228","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T13:09:16Z","timestamp":1742476156000},"page":"4921-4929","source":"Crossref","is-referenced-by-count":14,"title":["Acute pulmonary embolism: a multimarker calculator to predict short-term outcomes"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4571-7721","authenticated-orcid":false,"given":"David","family":"Jim\u00e9nez","sequence":"first","affiliation":[{"name":"Respiratory Department, Hospital Ram\u00f3n y Cajal and Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS) , M-607, Km. 9,100, 28034 Madrid ,","place":["Spain"]},{"name":"Medicine Department, Universidad de Alcal\u00e1 , Campus Cient\u00edfico-Tecnol\u00f3gico, Crta. de Madrid-Barcelona, Km. 33,600, 28805 Alcal\u00e1 de Henares, Madrid ,","place":["Spain"]},{"name":"CIBER Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III , C\/ Monforte de Lemos 3-5, 28029 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"Dubois-Silva","sequence":"additional","affiliation":[{"name":"Venous Thromboembolism Unit, Department of Internal Medicine, Complexo Hospitalario Universitario de A Coru\u00f1a (CHUAC) , A Coru\u00f1a ,","place":["Spain"]},{"name":"Universidade da Coru\u00f1a (UDC) , A Coru\u00f1a ,","place":["Spain"]},{"name":"Hospital at Home and Palliative Care Department, Complexo Hospitalario Universitario de A Coru\u00f1a (CHUAC) , A Coru\u00f1a ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Demelo-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital General Universitario Gregorio Mara\u00f1\u00f3n , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Ruiz-Artacho","sequence":"additional","affiliation":[{"name":"CIBER Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III , C\/ Monforte de Lemos 3-5, 28029 Madrid ,","place":["Spain"]},{"name":"Department of Internal Medicine, Cl\u00ednica Universidad de Navarra , Madrid ,","place":["Spain"]},{"name":"Interdisciplinar Teragnosis and Radiosomics Research Group (INTRA-Madrid), Universidad de Navarra , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jos\u00e9","family":"L\u00f3pez-N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"CIBER Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III , C\/ Monforte de Lemos 3-5, 28029 Madrid ,","place":["Spain"]},{"name":"Internal Medicine Department, Hospital Germans Trias i Pujol , Barcelona ,","place":["Spain"]},{"name":"Medicine Department, Universitat Aut\u00f2noma de Barcelona , Barcelona ,","place":["Spain"]},{"name":"Fundaci\u00f3 Institut Germans Trias i Pujol , Badalona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Mois\u00e9s","sequence":"additional","affiliation":[{"name":"Respiratory Department, Hospital Cl\u00ednic of Barcelona, IDIBAPS , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Muriel","sequence":"additional","affiliation":[{"name":"Biostatistics Department, Ram\u00f3n y Cajal Hospital and Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria IRYCIS, CIBERESP , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Bura-Riviere","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine, H\u00f4pital de Rangueil , Toulouse ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Mah\u00e9","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, H\u00f4pital Louis Mourier, Assistance Publique des H\u00f4pitaux de Paris (AP-HP) , Colombes ,","place":["France"]},{"name":"Inserm UMRS 1140 Innovations th\u00e9rapeutiques en h\u00e9mostase, Universit\u00e9 Paris Cit\u00e9 , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Barillari","sequence":"additional","affiliation":[{"name":"Center for Hemorrhagic and Thrombotic Diseases, General and University Hospital S. 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