{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T20:54:03Z","timestamp":1787432043903,"version":"build-2736575974"},"reference-count":149,"publisher":"Oxford University Press (OUP)","issue":"24","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Valvular heart disease (VHD) is a common condition that poses several challenges from the standpoints of diagnosis and therapeutic management. While several studies have explored the role of blood biomarkers in assessing the severity and risk of progression of VHD, as well as in evaluating related cardiac damage and predicting the occurrence of adverse events, blood biomarkers are generally not considered criteria to trigger valve intervention in the latest European and American guidelines for VHD management. This review article provides an up-to-date overview of the utility of blood biomarkers to (i) assess the presence, severity, and progression of left-sided VHD; (ii) establish the presence and extent of cardiovascular damage; (iii) predict clinical outcomes before and after valve interventions; and (iv) identify patients at risk for early structural valve deterioration, valve thrombosis, and paravalvular leak.<\/jats:p>","DOI":"10.1093\/eurheartj\/ehaf232","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T03:30:09Z","timestamp":1742700609000},"page":"2289-2305","source":"Crossref","is-referenced-by-count":16,"title":["Blood biomarkers in left-sided valvular heart disease"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1662-7874","authenticated-orcid":false,"given":"Augustin","family":"Coisne","sequence":"first","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID , Bd Pr Jules Leclercq, 59000 Lille ,","place":["France"]},{"name":"Cardiovascular Research Foundation , New York City, NY 10019 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizio","family":"Lancellotti","sequence":"additional","affiliation":[{"name":"GIGA Metabolism and Cardiovascular Biology, University of Li\u00e8ge , Li\u00e8ge ,","place":["Belgium"]},{"name":"Department of Cardiology, Heart Valve Clinic, University Hospital CHU Sart Tilman , Li\u00e8ge B-4000 ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec (Quebec Heart and Lung Institute), Universit\u00e9 Laval , Quebec City, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9629-5864","authenticated-orcid":false,"given":"Julien","family":"Ternacle","sequence":"additional","affiliation":[{"name":"Service M\u00e9dico-Chirurgical: Valvulopathies-Chirurgie Cardiaque-Cardiologie Interventionnelle Structurelle, Centre Hospitalier Universitaire Bordeaux , Bordeaux ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Hecht","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec (Quebec Heart and Lung Institute), Universit\u00e9 Laval , Quebec City, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4620-6234","authenticated-orcid":false,"given":"Julia","family":"Grapsa","sequence":"additional","affiliation":[{"name":"Guy\u2019s and St Thomas\u2019 NHS Trust Hospitals , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca T","family":"Hahn","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center\/NY Presbyterian Hospital , New York City, NY 10032 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8924-740X","authenticated-orcid":false,"given":"Marie-Annick","family":"Clavel","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec (Quebec Heart and Lung Institute), Universit\u00e9 Laval , Quebec City, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mani A","family":"Vannan","sequence":"additional","affiliation":[{"name":"Marcus Heart Valve Center, Piedmont Heart Institute , Atlanta, GA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6879-5343","authenticated-orcid":false,"given":"Brian","family":"Lindman","sequence":"additional","affiliation":[{"name":"Vanderbilt University , Nashville, TN ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madalina","family":"Garbi","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital, Cambridge University Health Partners, Cambridge Biomedical Campus , Cambridge ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7561-0132","authenticated-orcid":false,"given":"C\u00e9cile","family":"Oury","sequence":"additional","affiliation":[{"name":"GIGA Metabolism and Cardiovascular Biology, University of Li\u00e8ge , Li\u00e8ge ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2677-3389","authenticated-orcid":false,"given":"Erwan","family":"Donal","sequence":"additional","affiliation":[{"name":"Cardiology Department, CHU de Rennes , Rennes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4731-4384","authenticated-orcid":false,"given":"Andrea","family":"Scotti","sequence":"additional","affiliation":[{"name":"Montefiore-Einstein Center for Heart and Vascular Care, Montefiore Medical Center, Albert Einstein College , Bronx, NY 10467 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5752-4951","authenticated-orcid":false,"given":"Sebastian","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation , New York City, NY 10019 ,","place":["USA"]},{"name":"Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Postolache","sequence":"additional","affiliation":[{"name":"CHU UCL Namur- Site Godinne , Namur ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Myers","sequence":"additional","affiliation":[{"name":"H\u00f4pital de LaTour , Meyrin ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc R","family":"Dweck","sequence":"additional","affiliation":[{"name":"BHF Centre of Cardiovascular Science, The University of Edinburgh , Edinburgh ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3607-279X","authenticated-orcid":false,"given":"Philippe","family":"Pibarot","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec (Quebec Heart and Lung Institute), Universit\u00e9 Laval , Quebec City, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"key":"2025062608232688400_ehaf232-B1","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"2021 ESC\/EACTS guidelines for the management of valvular heart disease","volume":"43","author":"Vahanian","year":"2022","journal-title":"Eur Heart J"},{"key":"2025062608232688400_ehaf232-B2","doi-asserted-by":"publisher","first-page":"e25","DOI":"10.1016\/j.jacc.2020.11.018","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"77","author":"Writing Committee Members","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"2025062608232688400_ehaf232-B3","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.jacc.2023.05.061","article-title":"ACC\/AHA and ESC\/EACTS guidelines for the management of valvular heart diseases: JACC guideline comparison","volume":"82","author":"Coisne","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"2025062608232688400_ehaf232-B4","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1016\/j.jacc.2014.02.581","article-title":"B-type natriuretic peptide clinical activation in aortic stenosis: impact on long-term survival","volume":"63","author":"Clavel","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2025062608232688400_ehaf232-B5","doi-asserted-by":"publisher","first-page":"2302","DOI":"10.1161\/01.CIR.0000126825.50903.18","article-title":"Natriuretic peptides predict symptom-free survival and postoperative outcome in severe aortic stenosis","volume":"109","author":"Bergler-Klein","year":"2004","journal-title":"Circulation"},{"key":"2025062608232688400_ehaf232-B6","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1093\/eurheartj\/ehu189","article-title":"High-sensitivity troponin I concentrations are a marker of an advanced hypertrophic response and adverse outcomes in patients with aortic stenosis","volume":"35","author":"Chin","year":"2014","journal-title":"Eur Heart J"},{"key":"2025062608232688400_ehaf232-B7","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1136\/heartjnl-2015-307742","article-title":"Prognostic utility of novel biomarkers of cardiovascular stress in patients with aortic stenosis undergoing valve replacement","volume":"101","author":"Lindman","year":"2015","journal-title":"Heart"},{"key":"2025062608232688400_ehaf232-B8","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1136\/heartjnl-2016-310482","article-title":"Serum biomarkers in valvular heart disease","volume":"104","author":"Gardezi","year":"2018","journal-title":"Heart"},{"key":"2025062608232688400_ehaf232-B9","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1016\/j.jacc.2007.08.011","article-title":"Unoperated patients with severe aortic stenosis","volume":"50","author":"Bach","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"2025062608232688400_ehaf232-B10","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1016\/j.jacc.2021.09.864","article-title":"Contemporary management of severe symptomatic aortic stenosis","volume":"78","author":"Eug\u00e8ne","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"2025062608232688400_ehaf232-B11","doi-asserted-by":"publisher","first-page":"e020490","DOI":"10.1161\/JAHA.120.020490","article-title":"Association between patient survival and clinician variability in treatment rates for aortic valve stenosis","volume":"10","author":"Brennan","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"2025062608232688400_ehaf232-B12","doi-asserted-by":"publisher","first-page":"e025065","DOI":"10.1161\/JAHA.121.025065","article-title":"Patient- and process-related contributors to the underuse of aortic valve replacement and subsequent mortality in ambulatory patients with severe aortic stenosis","volume":"11","author":"Flannery","year":"2022","journal-title":"J Am Heart Assoc"},{"key":"2025062608232688400_ehaf232-B13","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1016\/j.jacc.2021.11.060","article-title":"Trends in utilization of aortic valve replacement for severe aortic stenosis","volume":"79","author":"Li","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"2025062608232688400_ehaf232-B14","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1016\/S0140-6736(18)30473-2","article-title":"Outcome and undertreatment of mitral regurgitation: a community cohort study","volume":"391","author":"Dziadzko","year":"2018","journal-title":"Lancet"},{"key":"2025062608232688400_ehaf232-B15","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.jacc.2013.09.038","article-title":"Elevated lipoprotein(a) and risk of aortic valve stenosis in the general population","volume":"63","author":"Kamstrup","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2025062608232688400_ehaf232-B16","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.amjcard.2018.04.046","article-title":"Comparison of lipoprotein(a)-levels in patients \u226570 years of age with versus without aortic valve stenosis","volume":"122","author":"Mahabadi","year":"2018","journal-title":"Am J Cardiol"},{"key":"2025062608232688400_ehaf232-B17","doi-asserted-by":"publisher","first-page":"oead032","DOI":"10.1093\/ehjopen\/oead032","article-title":"Impact of C-reactive protein levels on lipoprotein(a)-associated aortic stenosis incidence and progression","volume":"3","author":"Girard","year":"2023","journal-title":"Eur Heart J Open"},{"key":"2025062608232688400_ehaf232-B18","doi-asserted-by":"publisher","first-page":"3913","DOI":"10.1093\/eurheartj\/ehaa070","article-title":"Plasma lipids and risk of aortic valve stenosis: a Mendelian randomization study","volume":"41","author":"Nazarzadeh","year":"2020","journal-title":"Eur Heart J"},{"key":"2025062608232688400_ehaf232-B19","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/S0735-1097(96)00563-3","article-title":"Clinical factors associated with calcific aortic valve disease. Cardiovascular Health Study","volume":"29","author":"Stewart","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"2025062608232688400_ehaf232-B20","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1002\/clc.4960240109","article-title":"Association between calcific aortic stenosis and hypercholesterolemia: is there a need for a randomized controlled trial of cholesterol-lowering therapy?","volume":"24","author":"Chui","year":"2001","journal-title":"Clin Cardiol"},{"key":"2025062608232688400_ehaf232-B21","doi-asserted-by":"publisher","first-page":"3225","DOI":"10.1016\/j.jacc.2018.09.063","article-title":"PCSK9 involvement in aortic valve calcification","volume":"72","author":"Poggio","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2025062608232688400_ehaf232-B22","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.jacbts.2020.05.004","article-title":"Genetic and in vitro inhibition of PCSK9 and calcific aortic valve stenosis","volume":"5","author":"Perrot","year":"2020","journal-title":"JACC Basic Transl Sci"},{"key":"2025062608232688400_ehaf232-B23","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1001\/jamacardio.2020.0728","article-title":"An exploratory analysis of proprotein convertase subtilisin\/kexin type 9 inhibition and aortic stenosis in the FOURIER trial","volume":"5","author":"Bergmark","year":"2020","journal-title":"JAMA Cardiol"},{"key":"2025062608232688400_ehaf232-B24","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1016\/j.echo.2011.03.012","article-title":"Usefulness of plasma B-type natriuretic peptide in the assessment of disease severity and prediction of outcome after aortic valve replacement in patients with severe aortic stenosis","volume":"24","author":"Iwahashi","year":"2011","journal-title":"J Am Soc Echocardiogr"},{"key":"2025062608232688400_ehaf232-B25","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.1161\/01.CIR.0000060533.79248.0C","article-title":"Increased plasma natriuretic peptide levels reflect symptom onset in aortic stenosis","volume":"107","author":"Gerber","year":"2003","journal-title":"Circulation"},{"key":"2025062608232688400_ehaf232-B26","doi-asserted-by":"publisher","first-page":"2848","DOI":"10.1161\/CIRCULATIONAHA.106.654210","article-title":"B-type natriuretic peptide in low-flow, low-gradient aortic stenosis","volume":"115","author":"Bergler-Klein","year":"2007","journal-title":"Circulation"},{"key":"2025062608232688400_ehaf232-B27","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.jacc.2011.08.072","article-title":"Clinical outcome in asymptomatic severe aortic stenosis: insights from the new proposed aortic stenosis grading classification","volume":"59","author":"Lancellotti","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"2025062608232688400_ehaf232-B28","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.cjca.2015.06.007","article-title":"Impact of serial B-type natriuretic peptide changes for predicting outcome in asymptomatic patients with aortic stenosis","volume":"32","author":"Henri","year":"2016","journal-title":"Can J Cardiol"},{"key":"2025062608232688400_ehaf232-B29","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.amjcard.2004.11.053","article-title":"Usefulness of serial measurement of N-terminal pro-brain natriuretic peptide plasma levels in asymptomatic patients with aortic stenosis to predict symptomatic deterioration","volume":"95","author":"Gerber","year":"2005","journal-title":"Am J Cardiol"},{"key":"2025062608232688400_ehaf232-B30","doi-asserted-by":"publisher","first-page":"e001325","DOI":"10.1136\/openhrt-2020-001325","article-title":"Troponin T but not C reactive protein is associated with future surgery for aortic stenosis: a population-based nested case-referent study","volume":"7","author":"Holmgren","year":"2020","journal-title":"Open Heart"},{"key":"2025062608232688400_ehaf232-B31","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.amjcard.2011.02.346","article-title":"Prognostic usefulness of circulating high-sensitivity troponin T in aortic stenosis and relation to echocardiographic indexes of cardiac function and anatomy","volume":"108","author":"R\u00f8sj\u00f8","year":"2011","journal-title":"Am J Cardiol"},{"key":"2025062608232688400_ehaf232-B32","doi-asserted-by":"publisher","first-page":"e0138940","DOI":"10.1371\/journal.pone.0138940","article-title":"Elevated plasma soluble ST2 is associated with heart failure symptoms and outcome in aortic stenosis","volume":"10","author":"Lancellotti","year":"2015","journal-title":"PLoS One"},{"key":"2025062608232688400_ehaf232-B33","doi-asserted-by":"publisher","first-page":"3569","DOI":"10.3390\/ijms22073569","article-title":"Metabolomics in severe aortic stenosis reveals intermediates of nitric oxide synthesis as most distinctive markers","volume":"22","author":"van Driel","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2025062608232688400_ehaf232-B34","doi-asserted-by":"publisher","first-page":"95","DOI":"10.3390\/biom13010095","article-title":"Metabolomic profiling in patients with different hemodynamic subtypes of severe aortic valve stenosis","volume":"13","author":"Bengel","year":"2023","journal-title":"Biomolecules"},{"key":"2025062608232688400_ehaf232-B35","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1016\/j.jacbts.2020.10.001","article-title":"Metabolomic signature of human aortic valve stenosis","volume":"5","author":"Surendran","year":"2020","journal-title":"JACC Basic Transl Sci"},{"key":"2025062608232688400_ehaf232-B36","doi-asserted-by":"publisher","first-page":"2875","DOI":"10.1016\/j.ijcard.2012.07.021","article-title":"Myocardial and circulating levels of microRNA-21 reflect left ventricular fibrosis in aortic stenosis patients","volume":"167","author":"Villar","year":"2013","journal-title":"Int J Cardiol"},{"key":"2025062608232688400_ehaf232-B37","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1007\/s00018-022-04177-6","article-title":"MicroRNA-22 promoted osteogenic differentiation of valvular interstitial cells by inhibiting CAB39 expression during aortic valve calcification","volume":"79","author":"Yang","year":"2022","journal-title":"Cell Mol Life Sci"},{"key":"2025062608232688400_ehaf232-B38","doi-asserted-by":"publisher","first-page":"76","DOI":"10.3390\/ijms21010076","article-title":"MicroRNA-204 deficiency in human aortic valves elevates valvular osteogenic activity","volume":"21","author":"Song","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2025062608232688400_ehaf232-B39","doi-asserted-by":"publisher","first-page":"e91812","DOI":"10.1371\/journal.pone.0091812","article-title":"Prognostic value of circulating microRNA-210 levels in patients with moderate to severe aortic stenosis","volume":"9","author":"R\u00f8sj\u00f8","year":"2014","journal-title":"PLoS One"},{"key":"2025062608232688400_ehaf232-B40","doi-asserted-by":"publisher","first-page":"e105702","DOI":"10.1371\/journal.pone.0105702","article-title":"Circulating level of miR-378 predicts left ventricular hypertrophy in patients with aortic stenosis","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS One"},{"key":"2025062608232688400_ehaf232-B41","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.ahj.2008.04.011","article-title":"C-reactive protein predicts severity, progression, and prognosis of asymptomatic aortic valve stenosis","volume":"156","author":"Imai","year":"2008","journal-title":"Am Heart J"},{"key":"2025062608232688400_ehaf232-B42","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.jacc.2023.11.021","article-title":"Large-scale proteomics identifies novel biomarkers and circulating risk factors for aortic stenosis","volume":"83","author":"Shelbaya","year":"2024","journal-title":"J Am Coll Cardiol"},{"key":"2025062608232688400_ehaf232-B43","doi-asserted-by":"publisher","first-page":"2150","DOI":"10.1016\/j.jacc.2019.01.070","article-title":"Lipoprotein(a) and oxidized phospholipids promote valve calcification in patients with aortic stenosis","volume":"73","author":"Zheng","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2025062608232688400_ehaf232-B44","doi-asserted-by":"publisher","first-page":"2389","DOI":"10.1056\/NEJMoa043876","article-title":"A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis","volume":"352","author":"Cowell","year":"2005","journal-title":"N Engl J Med"},{"key":"2025062608232688400_ehaf232-B45","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1136\/heartjnl-2019-315840","article-title":"ApoCIII-Lp(a) complexes in conjunction with Lp(a)-OxPL predict rapid progression of aortic stenosis","volume":"106","author":"Capoulade","year":"2020","journal-title":"Heart"},{"key":"2025062608232688400_ehaf232-B46","doi-asserted-by":"publisher","first-page":"3925","DOI":"10.1093\/eurheartj\/ehac361","article-title":"Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement","volume":"43","author":"Kronenberg","year":"2022","journal-title":"Eur Heart J"},{"key":"2025062608232688400_ehaf232-B47","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.amjcard.2005.07.113","article-title":"Relation of circulating C-reactive protein to progression of aortic valve stenosis","volume":"97","author":"S\u00e1nchez","year":"2006","journal-title":"Am J Cardiol"},{"key":"2025062608232688400_ehaf232-B48","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.jcmg.2014.09.016","article-title":"Impact of plasma Lp-PLA2 activity on the progression of aortic stenosis: the PROGRESSA study","volume":"8","author":"Capoulade","year":"2015","journal-title":"JACC Cardiovasc Imaging"},{"key":"2025062608232688400_ehaf232-B49","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1161\/ATVBAHA.107.154989","article-title":"Association between plasma LDL particle size, valvular accumulation of oxidized LDL, and inflammation in patients with aortic stenosis","volume":"28","author":"Mohty","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2025062608232688400_ehaf232-B50","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1111\/j.1365-2362.2011.02522.x","article-title":"Angiotensin receptor blockers are associated with a lower remodelling score of stenotic aortic valves","volume":"41","author":"C\u00f4t\u00e9","year":"2011","journal-title":"Eur J Clin Invest"},{"key":"2025062608232688400_ehaf232-B51","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1111\/eci.12169","article-title":"Impact of hypertension and renin-angiotensin system inhibitors in aortic stenosis","volume":"43","author":"Capoulade","year":"2013","journal-title":"Eur J Clin Invest"},{"key":"2025062608232688400_ehaf232-B52","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.1136\/heartjnl-2020-317024","article-title":"Dipeptidyl peptidase-4 inhibition to prevent progression of calcific aortic stenosis","volume":"106","author":"Lee","year":"2020","journal-title":"Heart"},{"key":"2025062608232688400_ehaf232-B53","doi-asserted-by":"publisher","first-page":"851945","DOI":"10.1155\/2015\/851945","article-title":"Innate and adaptive immunity in calcific aortic valve disease","volume":"2015","author":"Mathieu","year":"2015","journal-title":"J Immunol Res"},{"key":"2025062608232688400_ehaf232-B54","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1002\/ejhf.242","article-title":"Suppression of neutrophil superoxide generation by BNP is attenuated in acute heart failure: a case for \u201cBNP resistance\u201d","volume":"17","author":"Liu","year":"2015","journal-title":"Eur J Heart Fail"},{"key":"2025062608232688400_ehaf232-B55","doi-asserted-by":"publisher","first-page":"145","DOI":"10.5935\/abc.20150151","article-title":"Soluble ST2 testing: a promising biomarker in the management of heart failure","volume":"106","author":"Villacorta","year":"2016","journal-title":"Arq Bras Cardiol"},{"key":"2025062608232688400_ehaf232-B56","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1093\/eurjhf\/hfs006","article-title":"Soluble ST2 is associated with adverse outcome in patients with heart failure of ischaemic aetiology","volume":"14","author":"Broch","year":"2012","journal-title":"Eur J Heart Fail"},{"key":"2025062608232688400_ehaf232-B57","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.jacc.2013.07.087","article-title":"Head-to-head comparison of 2 myocardial fibrosis biomarkers for long-term heart failure risk stratification: ST2 versus galectin-3","volume":"63","author":"Bayes-Genis","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2025062608232688400_ehaf232-B58","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.rec.2022.12.007","article-title":"Soluble ST2 levels are related to replacement myocardial fibrosis in severe aortic stenosis","volume":"76","author":"Arrieta","year":"2023","journal-title":"Rev Espanola Cardiol (Engl Ed)"},{"key":"2025062608232688400_ehaf232-B59","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1007\/s10554-017-1203-2","article-title":"The integrated value of sST2 and global longitudinal strain in the early stratification of patients with severe aortic valve stenosis: a translational imaging approach","volume":"33","author":"Fabiani","year":"2017","journal-title":"Int J Cardiovasc Imaging"},{"key":"2025062608232688400_ehaf232-B60","doi-asserted-by":"publisher","first-page":"e000916","DOI":"10.1136\/openhrt-2018-000916","article-title":"Multiple biomarker panel to screen for severe aortic stenosis: results from the CASABLANCA study","volume":"5","author":"Elmariah","year":"2018","journal-title":"Open Heart"},{"key":"2025062608232688400_ehaf232-B61","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1056\/NEJMoa022831","article-title":"Acquired von Willebrand syndrome in aortic stenosis","volume":"349","author":"Vincentelli","year":"2003","journal-title":"N Engl J Med"},{"key":"2025062608232688400_ehaf232-B62","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1056\/NEJMoa1505643","article-title":"Von Willebrand factor multimers during transcatheter aortic-valve replacement","volume":"375","author":"Van Belle","year":"2016","journal-title":"N Engl J Med"},{"key":"2025062608232688400_ehaf232-B63","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1016\/j.jacc.2018.12.045","article-title":"von Willebrand factor and management of heart valve disease: JACC review topic of the week","volume":"73","author":"Van Belle","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2025062608232688400_ehaf232-B64","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1161\/CIRCRESAHA.124.324248","article-title":"Shear-sensing by C-reactive protein: linking aortic stenosis and inflammation","volume":"135","author":"Zeller","year":"2024","journal-title":"Circ Res"},{"key":"2025062608232688400_ehaf232-B65","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1001\/jamacardio.2024.1882","article-title":"Lipoprotein(a) and calcific aortic valve stenosis progression: a systematic review and meta-analysis","volume":"9","author":"Arsenault","year":"2024","journal-title":"JAMA Cardiol"},{"key":"2025062608232688400_ehaf232-B66","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.jacc.2013.05.105","article-title":"Elevated expression of lipoprotein-associated phospholipase A2 in calcific aortic valve disease: implications for valve mineralization","volume":"63","author":"Mahmut","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2025062608232688400_ehaf232-B67","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.ijcard.2009.05.054","article-title":"Oxidized low-density lipoprotein, angiotensin II and increased waist cirumference are associated with valve inflammation in prehypertensive patients with aortic stenosis","volume":"145","author":"C\u00f4t\u00e9","year":"2010","journal-title":"Int J Cardiol"},{"key":"2025062608232688400_ehaf232-B68","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1016\/j.cjca.2024.03.009","article-title":"Angiotensin II receptor blockers are associated with reduced valvular fibrosis in women with aortic stenosis","volume":"40","author":"Carter-Storch","year":"2024","journal-title":"Can J Cardiol"},{"key":"2025062608232688400_ehaf232-B69","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1016\/j.jacc.2024.06.037","article-title":"Effect of evogliptin on the progression of aortic valvular calcification","volume":"84","author":"Song","year":"2024","journal-title":"J Am Coll Cardiol"},{"key":"2025062608232688400_ehaf232-B70","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/386078a0","article-title":"Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein","volume":"386","author":"Luo","year":"1997","journal-title":"Nature"},{"key":"2025062608232688400_ehaf232-B71","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1177\/0003319717708070","article-title":"Von Willebrand factor as a novel player in valvular heart disease: from bench to valve replacement","volume":"69","author":"Gragnano","year":"2018","journal-title":"Angiology"},{"key":"2025062608232688400_ehaf232-B72","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s11306-019-1518-1","article-title":"Disturbed energy and amino acid metabolism with their diagnostic potential in mitral valve disease revealed by untargeted plasma metabolic profiling","volume":"15","author":"Jiang","year":"2019","journal-title":"Metabolomics"},{"key":"2025062608232688400_ehaf232-B73","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s12014-015-9097-2","article-title":"New biomarkers for primary mitral regurgitation","volume":"12","author":"Deroyer","year":"2015","journal-title":"Clin Proteomics"},{"key":"2025062608232688400_ehaf232-B74","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.jprot.2013.10.009","article-title":"Proteomics discovery of biomarkers for mitral regurgitation caused by mitral valve prolapse","volume":"94","author":"Tan","year":"2013","journal-title":"J Proteomics"},{"key":"2025062608232688400_ehaf232-B75","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1093\/ehjci\/jev338","article-title":"Lipoprotein(a) is a risk factor for aortic and mitral valvular stenosis in peripheral arterial disease","volume":"17","author":"Hojo","year":"2016","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2025062608232688400_ehaf232-B76","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.atherosclerosis.2021.11.029","article-title":"Elevated lipoprotein(a) in mitral and aortic valve calcification and disease: the Copenhagen General Population Study","volume":"349","author":"Kaltoft","year":"2022","journal-title":"Atherosclerosis"},{"key":"2025062608232688400_ehaf232-B77","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.jcct.2020.06.002","article-title":"Lipoprotein (a) and risk for calcification of the coronary arteries, mitral valve, and thoracic aorta: the Multi-Ethnic Study of Atherosclerosis","volume":"15","author":"Garg","year":"2021","journal-title":"J Cardiovasc Comput Tomogr"},{"key":"2025062608232688400_ehaf232-B78","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1161\/01.CIR.0000164269.80908.9D","article-title":"B-type natriuretic peptide in organic mitral regurgitation: determinants and impact on outcome","volume":"111","author":"Detaint","year":"2005","journal-title":"Circulation"},{"key":"2025062608232688400_ehaf232-B79","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1136\/heartjnl-2011-301128","article-title":"Prognostic importance of brain natriuretic peptide and left ventricular longitudinal function in asymptomatic degenerative mitral regurgitation","volume":"98","author":"Magne","year":"2012","journal-title":"Heart"},{"key":"2025062608232688400_ehaf232-B80","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1093\/eurjhf\/hfs114","article-title":"Prognostic importance of exercise brain natriuretic peptide in asymptomatic degenerative mitral regurgitation","volume":"14","author":"Magne","year":"2012","journal-title":"Eur J Heart Fail"},{"key":"2025062608232688400_ehaf232-B81","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1016\/j.jacc.2016.06.047","article-title":"Association of B-type natriuretic peptide with survival in patients with degenerative mitral regurgitation","volume":"68","author":"Clavel","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"2025062608232688400_ehaf232-B82","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1016\/j.jacc.2009.06.013","article-title":"Prospective validation of the prognostic usefulness of brain natriuretic peptide in asymptomatic patients with chronic severe mitral regurgitation","volume":"54","author":"Pizarro","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"2025062608232688400_ehaf232-B83","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1093\/eurjhf\/hfq189","article-title":"Prognostic value of serial B-type natriuretic peptide measurement in asymptomatic organic mitral regurgitation","volume":"13","author":"Klaar","year":"2011","journal-title":"Eur J Heart Fail"},{"key":"2025062608232688400_ehaf232-B84","doi-asserted-by":"publisher","first-page":"2924","DOI":"10.1002\/ehf2.14845","article-title":"Human epididymis protein 4 is a useful predictor of post-operative prognosis in patients with severe aortic stenosis","volume":"11","author":"Ogata","year":"2024","journal-title":"ESC Heart Fail"},{"key":"2025062608232688400_ehaf232-B85","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.ijcard.2016.07.179","article-title":"Circulating miR-148b-3p and miR-409-3p as biomarkers for heart failure in patients with mitral regurgitation","volume":"222","author":"Chen","year":"2016","journal-title":"Int J Cardiol"},{"key":"2025062608232688400_ehaf232-B86","doi-asserted-by":"publisher","first-page":"e13381","DOI":"10.1111\/eci.13381","article-title":"Secondary mitral regurgitation-insights from microRNA assessment","volume":"51","author":"Spinka","year":"2021","journal-title":"Eur J Clin Invest"},{"key":"2025062608232688400_ehaf232-B87","doi-asserted-by":"publisher","first-page":"477","DOI":"10.5603\/CJ.a2018.0108","article-title":"The usefulness of selected biomarkers in aortic regurgitation","volume":"26","author":"Duchnowski","year":"2019","journal-title":"Cardiol J"},{"key":"2025062608232688400_ehaf232-B88","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1016\/j.jacc.2011.07.016","article-title":"Prospective validation of the prognostic usefulness of B-type natriuretic peptide in asymptomatic patients with chronic severe aortic regurgitation","volume":"58","author":"Pizarro","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"2025062608232688400_ehaf232-B89","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1093\/eurheartj\/ehz892","article-title":"Low and elevated B-type natriuretic peptide levels are associated with increased mortality in patients with preserved ejection fraction undergoing transcatheter aortic valve replacement: an analysis of the PARTNER II trial and registry","volume":"41","author":"Chen","year":"2020","journal-title":"Eur Heart J"},{"key":"2025062608232688400_ehaf232-B90","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.1016\/j.jacc.2013.08.1621","article-title":"The complex nature of discordant severe calcified aortic valve disease grading: new insights from combined Doppler echocardiographic and computed tomographic study","volume":"62","author":"Clavel","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"2025062608232688400_ehaf232-B91","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1016\/j.jacc.2020.02.031","article-title":"Prognostic value of N-terminal pro-B-type natriuretic peptide in elderly patients with valvular heart disease","volume":"75","author":"Zhang","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"2025062608232688400_ehaf232-B92","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1016\/S0735-1097(02)02059-4","article-title":"Plasma brain natriuretic peptide concentration: impact of age and gender","volume":"40","author":"Redfield","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"2025062608232688400_ehaf232-B93","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.cca.2012.07.017","article-title":"State of the art of BNP and NT-proBNP immunoassays: the CardioOrmoCheck study","volume":"414","author":"Clerico","year":"2012","journal-title":"Clin Chim Acta"},{"key":"2025062608232688400_ehaf232-B94","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1001\/jama.2024.22730","article-title":"Early intervention in patients with asymptomatic severe aortic stenosis and myocardial fibrosis: the EVOLVED randomized clinical trial","volume":"333","author":"Loganath","year":"2025;","journal-title":"JAMA"},{"key":"2025062608232688400_ehaf232-B95","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1002\/ejhf.318","article-title":"Elevated growth differentiation factor 15 levels predict outcome in patients undergoing transcatheter aortic valve implantation","volume":"17","author":"Krau","year":"2015","journal-title":"Eur J Heart Fail"},{"key":"2025062608232688400_ehaf232-B96","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1016\/j.ijcard.2014.10.010","article-title":"Galectin-3 predicts short- and long-term outcome in patients undergoing transcatheter aortic valve implantation (TAVI)","volume":"177","author":"Baldenhofer","year":"2014","journal-title":"Int J Cardiol"},{"key":"2025062608232688400_ehaf232-B97","doi-asserted-by":"publisher","first-page":"BSR20202306","DOI":"10.1042\/BSR20202306","article-title":"Preprocedural circulating galectin-3 and the risk of mortality after transcatheter aortic valve replacement: a systematic review and meta-analysis","volume":"40","author":"Zhang","year":"2020","journal-title":"Biosci Rep"},{"key":"2025062608232688400_ehaf232-B98","doi-asserted-by":"publisher","first-page":"129","DOI":"10.5603\/CJ.a2019.0052","article-title":"ST2 in patients with severe aortic stenosis and heart failure","volume":"28","author":"Cai","year":"2021","journal-title":"Cardiol J"},{"key":"2025062608232688400_ehaf232-B99","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1095\/biolreprod45.2.350","article-title":"A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors","volume":"45","author":"Kirchhoff","year":"1991","journal-title":"Biol Reprod"},{"key":"2025062608232688400_ehaf232-B100","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1515\/cclm-2012-0097","article-title":"Human epididymis protein 4 (HE4) in benign and malignant diseases","volume":"50","author":"Hertlein","year":"2012","journal-title":"Clin Chem Lab Med"},{"key":"2025062608232688400_ehaf232-B101","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.it.2008.07.001","article-title":"Novel innate immune functions of the whey acidic protein family","volume":"29","author":"Bingle","year":"2008","journal-title":"Trends Immunol"},{"key":"2025062608232688400_ehaf232-B102","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.jchf.2012.11.005","article-title":"The WAP four-disulfide core domain protein HE4: a novel biomarker for heart failure","volume":"1","author":"de Boer","year":"2013","journal-title":"JACC Heart Fail"},{"key":"2025062608232688400_ehaf232-B103","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.cardfail.2016.05.002","article-title":"HE4 serum levels are associated with heart failure severity in patients with chronic heart failure","volume":"23","author":"Piek","year":"2017","journal-title":"J Card Fail"},{"key":"2025062608232688400_ehaf232-B104","doi-asserted-by":"publisher","first-page":"e021069","DOI":"10.1161\/JAHA.120.021069","article-title":"HE4 predicts progressive fibrosis and cardiovascular events in patients with dilated cardiomyopathy","volume":"10","author":"Yamamoto","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"2025062608232688400_ehaf232-B105","doi-asserted-by":"publisher","first-page":"100761","DOI":"10.1016\/j.jacadv.2023.100761","article-title":"Multimarker approach to improve risk stratification of patients undergoing transcatheter aortic valve implantation","volume":"3","author":"Hecht","year":"2024","journal-title":"JACC Adv"},{"key":"2025062608232688400_ehaf232-B106","doi-asserted-by":"publisher","first-page":"e000211","DOI":"10.1161\/JAHA.113.000211","article-title":"Circulating levels of miR-133a predict the regression potential of left ventricular hypertrophy after valve replacement surgery in patients with aortic stenosis","volume":"2","author":"Garc\u00eda","year":"2013","journal-title":"J Am Heart Assoc"},{"key":"2025062608232688400_ehaf232-B107","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1002\/clc.22996","article-title":"Galectin-3 and ST2 as predictors of therapeutic success in high-risk patients undergoing percutaneous mitral valve repair (MitraClip)","volume":"41","author":"D\u00f6rr","year":"2018","journal-title":"Clin Cardiol"},{"key":"2025062608232688400_ehaf232-B108","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1055\/s-0033-1356751","article-title":"Interleukin-1 receptor-related protein ST2 and mitral valve repair outcome in patients with chronic degenerative mitral regurgitation","volume":"62","author":"Galeone","year":"2014","journal-title":"Thorac Cardiovasc Surg"},{"key":"2025062608232688400_ehaf232-B109","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1515\/CCLM.2006.063","article-title":"Clinical relevance of biological variation: the lesson of brain natriuretic peptide (BNP) and NT-proBNP assay","volume":"44","author":"Clerico","year":"2006","journal-title":"Clin Chem Lab Med"},{"key":"2025062608232688400_ehaf232-B110","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1056\/NEJMoa1114705","article-title":"Registry of transcatheter aortic-valve implantation in high-risk patients","volume":"366","author":"Gilard","year":"2012","journal-title":"N Engl J Med"},{"key":"2025062608232688400_ehaf232-B111","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1161\/CIRCULATIONAHA.116.026349","article-title":"Predictors and association with clinical outcomes of the changes in exercise capacity after transcatheter aortic valve replacement","volume":"136","author":"Abdul-Jawad Altisent","year":"2017","journal-title":"Circulation"},{"key":"2025062608232688400_ehaf232-B112","doi-asserted-by":"publisher","first-page":"e38","DOI":"10.1016\/j.ijcard.2013.08.108","article-title":"Preprocedural high-sensitive troponin predicts survival after transcatheter aortic valve implantation (TAVI)","volume":"169","author":"Frank","year":"2013","journal-title":"Int J Cardiol"},{"key":"2025062608232688400_ehaf232-B113","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s00392-013-0624-8","article-title":"Preserved prognostic value of preinterventional troponin T levels despite successful TAVI in patients with severe aortic stenosis","volume":"103","author":"Chorianopoulos","year":"2014","journal-title":"Clin Res Cardiol"},{"key":"2025062608232688400_ehaf232-B114","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1111\/1755-5922.12208","article-title":"Preprocedural but not periprocedural high-sensitive troponin T levels predict outcome in patients undergoing transcatheter aortic valve implantation","volume":"34","author":"K\u00f6hler","year":"2016","journal-title":"Cardiovasc Ther"},{"key":"2025062608232688400_ehaf232-B115","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1002\/ejhf.2361","article-title":"Plasma biomarkers associated with adverse outcomes in patients with calcific aortic stenosis","volume":"23","author":"Vidula","year":"2021","journal-title":"Eur J Heart Fail"},{"key":"2025062608232688400_ehaf232-B116","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.ijcard.2017.06.066","article-title":"ST2 predicts survival in patients undergoing transcatheter aortic valve implantation","volume":"244","author":"Schmid","year":"2017","journal-title":"Int J Cardiol"},{"key":"2025062608232688400_ehaf232-B117","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/j.amjcard.2017.06.033","article-title":"Soluble ST2 for risk stratification and the prediction of mortality in patients undergoing transcatheter aortic valve implantation","volume":"120","author":"Stundl","year":"2017","journal-title":"Am J Cardiol"},{"key":"2025062608232688400_ehaf232-B118","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/eci.12719","article-title":"Soluble ST2 predicts 1-year outcome in patients undergoing transcatheter aortic valve implantation","volume":"47","author":"Wernly","year":"2017","journal-title":"Eur J Clin Invest"},{"key":"2025062608232688400_ehaf232-B119","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1001\/jamacardio.2020.2614","article-title":"Association of natriuretic peptide levels after transcatheter aortic valve replacement with subsequent clinical outcomes","volume":"5","author":"O\u2019Leary","year":"2020","journal-title":"JAMA Cardiol"},{"key":"2025062608232688400_ehaf232-B120","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.jcin.2013.02.006","article-title":"Tumor marker carbohydrate antigen 125 predicts adverse outcome after transcatheter aortic valve implantation","volume":"6","author":"Husser","year":"2013","journal-title":"JACC Cardiovasc Interv"},{"key":"2025062608232688400_ehaf232-B121","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1016\/j.cmet.2016.05.023","article-title":"Quantification of GDF11 and myostatin in human aging and cardiovascular disease","volume":"23","author":"Schafer","year":"2016","journal-title":"Cell Metab"},{"key":"2025062608232688400_ehaf232-B122","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.ahj.2015.07.003","article-title":"Risk scores and biomarkers for the prediction of 1-year outcome after transcatheter aortic valve replacement","volume":"170","author":"Sinning","year":"2015","journal-title":"Am Heart J"},{"key":"2025062608232688400_ehaf232-B123","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/j.amjcard.2016.11.019","article-title":"Prognostic value of hypoalbuminemia after transcatheter aortic valve implantation (from the Japanese Multicenter OCEAN-TAVI Registry)","volume":"119","author":"Yamamoto","year":"2017","journal-title":"Am J Cardiol"},{"key":"2025062608232688400_ehaf232-B124","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1016\/j.jcin.2015.02.008","article-title":"Treatment of acquired von Willebrand syndrome in aortic stenosis with transcatheter aortic valve replacement","volume":"8","author":"Spangenberg","year":"2015","journal-title":"JACC Cardiovasc Interv"},{"key":"2025062608232688400_ehaf232-B125","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1136\/hrt.2010.217273","article-title":"Increased thrombin generation and platelet activation are associated with deficiency in high molecular weight multimers of von Willebrand factor in patients with moderate-to-severe aortic stenosis","volume":"97","author":"Natorska","year":"2011","journal-title":"Heart"},{"key":"2025062608232688400_ehaf232-B126","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1136\/heartjnl-2013-303910","article-title":"Progressive rise in red cell distribution width is associated with poor outcome after transcatheter aortic valve implantation","volume":"99","author":"Aung","year":"2013","journal-title":"Heart"},{"key":"2025062608232688400_ehaf232-B127","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.repc.2019.09.014","article-title":"MicroRNAs and ventricular remodeling in aortic stenosis","volume":"39","author":"Santos-Faria","year":"2020","journal-title":"Rev Port Cardiol"},{"key":"2025062608232688400_ehaf232-B128","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1016\/j.jcin.2017.09.020","article-title":"Prognostic implications of pre-procedural high-sensitivity cardiac troponin T in patients undergoing transcatheter aortic valve replacement","volume":"10","author":"Kofler","year":"2017","journal-title":"JACC Cardiovasc Interv"},{"key":"2025062608232688400_ehaf232-B129","doi-asserted-by":"publisher","first-page":"2998","DOI":"10.3390\/jcm9092998","article-title":"Growth differentiation factor 15 in severe aortic valve stenosis: relationship with left ventricular remodeling and frailty","volume":"9","author":"Fabiani","year":"2020","journal-title":"J Clin Med"},{"key":"2025062608232688400_ehaf232-B130","doi-asserted-by":"publisher","first-page":"e845","DOI":"10.4244\/EIJ-D-23-01050","article-title":"Durability of transcatheter aortic valve implantation","volume":"20","author":"Ternacle","year":"2024","journal-title":"EuroIntervention"},{"key":"2025062608232688400_ehaf232-B131","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1016\/j.jacc.2018.01.059","article-title":"Long-term outcomes following surgical aortic bioprosthesis implantation","volume":"71","author":"Rodriguez-Gabella","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2025062608232688400_ehaf232-B132","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/S0022-5223(02)73619-2","article-title":"Risk factors for atherosclerosis and the degeneration of pericardial valves after aortic valve replacement","volume":"126","author":"Nollert","year":"2003","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2025062608232688400_ehaf232-B133","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1016\/j.cjca.2019.05.028","article-title":"Chronic kidney disease and the pathophysiology of valvular heart disease","volume":"35","author":"Ternacle","year":"2019","journal-title":"Can J Cardiol"},{"key":"2025062608232688400_ehaf232-B134","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1016\/j.jacc.2019.01.043","article-title":"Oral anticoagulation therapy and progression of calcific aortic valve stenosis","volume":"73","author":"Tastet","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2025062608232688400_ehaf232-B135","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1161\/CIRCULATIONAHA.118.035150","article-title":"Rate, timing, correlates, and outcomes of hemodynamic valve deterioration after bioprosthetic surgical aortic valve replacement","volume":"138","author":"Salaun","year":"2018","journal-title":"Circulation"},{"key":"2025062608232688400_ehaf232-B136","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1161\/CIRCULATIONAHA.111.025064","article-title":"Type 2 diabetes mellitus is associated with faster degeneration of bioprosthetic valve: results from a propensity score-matched Italian multicenter study","volume":"125","author":"Lorusso","year":"2012","journal-title":"Circulation"},{"key":"2025062608232688400_ehaf232-B137","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.jacc.2018.04.064","article-title":"Hemodynamic deterioration of surgically implanted bioprosthetic aortic valves","volume":"72","author":"Salaun","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2025062608232688400_ehaf232-B138","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1136\/heartjnl-2016-309541","article-title":"Association between plasma lipoprotein levels and bioprosthetic valve structural degeneration","volume":"102","author":"Nsaibia","year":"2016","journal-title":"Heart"},{"key":"2025062608232688400_ehaf232-B139","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1111\/eci.12199","article-title":"Lp-PLA2 is associated with structural valve degeneration of bioprostheses","volume":"44","author":"Mahmut","year":"2014","journal-title":"Eur J Clin Invest"},{"key":"2025062608232688400_ehaf232-B140","doi-asserted-by":"publisher","first-page":"e005648","DOI":"10.1161\/JAHA.117.005648","article-title":"Calcification and oxidative modifications are associated with progressive bioprosthetic heart valve dysfunction","volume":"6","author":"Lee","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"2025062608232688400_ehaf232-B141","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.cca.2018.06.045","article-title":"Soluble CD14 is associated with the structural failure of bioprostheses","volume":"485","author":"Nsaibia","year":"2018","journal-title":"Clin Chim Acta"},{"key":"2025062608232688400_ehaf232-B142","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1136\/heartjnl-2014-306445","article-title":"Determinants of aortic bioprosthetic valve calcification assessed by multidetector CT","volume":"101","author":"Mahjoub","year":"2015","journal-title":"Heart"},{"key":"2025062608232688400_ehaf232-B143","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1007\/s00059-013-4038-1","article-title":"Role of anticardiolipin antibodies in the pathogenesis of prosthetic valve thrombosis: an observational study","volume":"40","author":"Aykan","year":"2015","journal-title":"Herz"},{"key":"2025062608232688400_ehaf232-B144","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1016\/j.amjcard.2013.11.029","article-title":"Usefulness of novel hematologic inflammatory parameters to predict prosthetic mitral valve thrombosis","volume":"113","author":"G\u00fcrsoy","year":"2014","journal-title":"Am J Cardiol"},{"key":"2025062608232688400_ehaf232-B145","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1055\/s-0038-1639352","article-title":"CT-ADP point-of-care assay predicts 30-day paravalvular aortic regurgitation and bleeding events following transcatheter aortic valve replacement","volume":"118","author":"Kibler","year":"2018","journal-title":"Thromb Haemost"},{"key":"2025062608232688400_ehaf232-B146","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1002\/ccd.25295","article-title":"Clinical impact of paravalvular leaks on biomarkers and survival after transcatheter aortic valve implantation","volume":"85","author":"Schewel","year":"2015","journal-title":"Catheter Cardiovasc Interv"},{"key":"2025062608232688400_ehaf232-B147","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1093\/eurheartj\/ehx211","article-title":"Clinical trial principles and endpoint definitions for paravalvular leaks in surgical prosthesis","volume":"39","author":"Ruiz","year":"2018","journal-title":"Eur Heart J"},{"key":"2025062608232688400_ehaf232-B148","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.jcmg.2017.06.018","article-title":"B-type natriuretic peptide and high-sensitivity cardiac troponin for risk stratification in low-flow, low-gradient aortic stenosis: a substudy of the TOPAS study","volume":"11","author":"Dahou","year":"2018","journal-title":"JACC Cardiovasc Imaging"},{"key":"2025062608232688400_ehaf232-B149","doi-asserted-by":"publisher","first-page":"2172","DOI":"10.1016\/j.jcin.2018.07.039","article-title":"Multimarker approach to identify patients with higher mortality and rehospitalization rate after surgical aortic valve replacement for aortic stenosis","volume":"11","author":"Lindman","year":"2018","journal-title":"JACC Cardiovasc Interv"}],"container-title":["European Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/46\/24\/2289\/62974685\/ehaf232.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurheartj\/article-pdf\/46\/24\/2289\/62974685\/ehaf232.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T08:23:32Z","timestamp":1750926212000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurheartj\/article\/46\/24\/2289\/8117240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,22]]},"references-count":149,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2025,4,22]]},"published-print":{"date-parts":[[2025,6,23]]}},"URL":"https:\/\/doi.org\/10.1093\/eurheartj\/ehaf232","relation":{},"ISSN":["0195-668X","1522-9645"],"issn-type":[{"value":"0195-668X","type":"print"},{"value":"1522-9645","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,6,21]]},"published":{"date-parts":[[2025,4,22]]}}}