{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:59:19Z","timestamp":1792677559661,"version":"4.5.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"25","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23HL114868"],"award-info":[{"award-number":["K23HL114868"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["L30HL115790"],"award-info":[{"award-number":["L30HL115790"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL139629"],"award-info":[{"award-number":["R01HL139629"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21HL143092"],"award-info":[{"award-number":["R21HL143092"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL128973"],"award-info":[{"award-number":["R01HL128973"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL148354"],"award-info":[{"award-number":["R01HL148354"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK113191"],"award-info":[{"award-number":["R01DK113191"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30DK079210"],"award-info":[{"award-number":["P30DK079210"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>Limited data are available to assess oral diuretic response in outpatients with heart failure (HF). The natriuretic response prediction equation (NRPE) predicts natriuresis following a loop diuretic dose using a urine sample 2\u2005h after the dose and was validated to accurately predict intravenous diuretic response. The primary aim was to validate the NRPE\u2019s assessment of oral diuretic response in patients with HF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The NRPE was evaluated in two HF patient cohorts receiving oral loop diuretics: Mechanisms of Diuretic Resistance (MDR) and TRANSFORM-Mechanism. Participants received their home oral loop diuretic followed by a supervised timed urine collection including spot urine samples at 1 and 2\u2005h. Patients quantified their self-assessed diuretic response (urine volume) via a standardized survey. A poor diuretic response was defined as cumulative natriuresis &amp;lt; 50\u2005mmol over the study visit.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The MDR cohort included 318 oral diuretic administrations from 237 patients. The NRPE predicted a poor natriuretic response with an area under the curve (AUC) of .87 [95% confidence interval (CI) .83\u2013.91] and similar accuracy to the previously validated intravenous NRPE performance (P = .16). Patient\u2019s ability to self-estimate their diuretic response was poor with an AUC of .57 (95% CI .44\u2013.70) and significantly worse than the oral NRPE (P &amp;lt; .001). In TRANSFORM-Mechanism (110 oral diuretic administrations), the NRPE had similar operating characteristics (AUC .89, 95% CI .80\u20131.0) for poor diuretic response.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Natriuretic response to an oral diuretic can be rapidly and accurately assessed with a urine sample collected 2\u2005h after an oral diuretic dose and the NRPE.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehaf268","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T12:58:29Z","timestamp":1745499509000},"page":"2410-2418","source":"Crossref","is-referenced-by-count":6,"title":["Natriuretic response prediction equation for use with oral diuretics in heart failure"],"prefix":"10.1093","volume":"46","author":[{"given":"Juan B","family":"Ivey-Miranda","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Section of Cardiovascular Medicine, Yale University School of Medicine , USA"},{"name":"Department of Heart Failure, Hospital de Cardiologia, Instituto Mexicano del Seguro Social , Mexico City ,","place":["Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veena S","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Cardiovascular Medicine, Yale University School of Medicine , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary L","family":"Cox","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Lipscomb University College of Pharmacy , Nashville, TN, USA"},{"name":"Department of Medicine, Vanderbilt University School of Medicine , Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6966-8795","authenticated-orcid":false,"given":"Julieta","family":"Moreno-Villagomez","sequence":"additional","affiliation":[{"name":"Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico , Mexico City ,","place":["Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Ramos Mastache","sequence":"additional","affiliation":[{"name":"Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico , Mexico City ,","place":["Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean P","family":"Collins","sequence":"additional","affiliation":[{"name":"Deparment of Emergency Medicine, Vanderbilt University Medical Center, Geriatric Research and Education Clinical Care, Tennessee Valley Healthcare Facility VA Medical Center , Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M","family":"Testani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Cardiovascular Medicine, Yale University School of Medicine , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,4,24]]},"reference":[{"key":"2025063022212779000_ehaf268-B1","doi-asserted-by":"publisher","first-page":"e263","DOI":"10.1016\/j.jacc.2021.12.012","article-title":"2022 AHA\/ACC\/HFSA guideline for the management of heart failure: a report of the American College of Cardiology\/American Heart Association Joint Committee on clinical practice guidelines","volume":"79","author":"Heidenreich","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"2025063022212779000_ehaf268-B2","doi-asserted-by":"publisher","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC guidelines for the diagnosis and 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